Peter J. Goadsby

Effectiveness of Rimegepant for the Acute Treatment of Migraine Among Participants Using Different Types of Preventive Therapy: Analyses from CONFIDENCE

Richard B. Lipton, Peter J. Goadsby, Patricia Pozo‐Rosich, Alexandre Urani et autres

INTRODUCTION: This analysis assessed the real-world effectiveness of rimegepant for the acute treatment of migraine in patients taking different types of preventive medication. METHODS: app. Over a 28-day period, participants reported daily on the occurrence, treatment, and outcomes of migraine attacks. The …

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EMHA migraine scoring system: A novel, valid, and reliable metric to capture severity, align with patients, and facilitate communication

Patricia Pozo‐Rosich, Edoardo Caronna, Elena Ruiz de la Torre, Messoud Ashina et autres

Background Available instruments to quantify migraine-related disability, such as the Headache Impact Test (HIT-6) and Migraine Disability Assessment Test (MIDAS), have certain limitations (e.g., recall bias, overlooking interictal burden), and do not always facilitate patient-doctor communication. We developed a migraine scoring system, …

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Efficacy of lamotrigine in the treatment of migraine with aura: A retrospective observational case series

Ahmed Abdalla, Peter J. Goadsby

Background and Aim Lamotrigine is sometimes identified as a useful preventive in migraine with aura. We evaluated our experience with the efficacy and tolerability of lamotrigine in the treatment of migraine with aura. Methods A service evaluation of responses to lamotrigine at …

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Machine Learning Assessment of Next-Day Migraine Likelihood Using Data From 53,000 App Users Living With Migraine

Liron Rabany, Anastasia Markina, Robert P. Cowan, Christopher L. Robinson et autres

The ability to anticipate an impending migraine attack has the potential to improve patients' well-being, yet previous models have shown limited performance. The current study aimed to develop and evaluate a machine learning (ML) model to identify risk of next-day migraine attacks …

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Migraine in the cradle of civilization: Evaluating ancient Mesopotamian texts through the lens of ICHD ‐3

Bülent DİRİ, Bilge Piri Çınar, Zeynep Sena Diri, Okan BÖLÜKBAŞI et autres

BACKGROUND: Migraine is a neurological disorder with well-established diagnostic criteria. In its current formulation, migraine is a modern-day diagnosis, whereas descriptions consistent with migraine may date back to ancient civilizations. OBJECTIVE: This study aimed to investigate whether symptoms consistent with migraine without …

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Effectiveness and predictors of response to intravenous dihydroergotamine in the treatment of primary headache disorders: A service evaluation

Pubudu Amarasena, Fiona Greenwood, Peter J. Goadsby

Background: Dihydroergotamine has been used to treat headache for eighty years. We aimed to identify factors affecting the response to DHE infusion. Methods: A retrospective service evaluation was conducted using routinely collected clinical data. Successive DHE admissions ( n = 160) were …

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Reduced REM sleep fast theta power suggests early circuit vulnerability in a GBA1 mouse model of prodromal synucleinopathy

Veronica Munday, Çiğdem Gelegen, Gemma Deegan, Katarina Ilic et autres

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Disorder-specific alterations of transient oscillatory dynamics during sleep across cortical and subcortical networks

Nazanin Biabani, Katarina Ilic, Adam Birdseye, Olga Ivanenko et autres

Transient sleep oscillations reflect the dynamic coordination of cortical and subcortical circuits, modulated by slow oscillatory activity. However, the disorder-specific signatures of these events across neurological, pain, and sleep disorders remain poorly characterized. In this exploratory study, we analyzed transient oscillatory dynamics …

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Differential motor signatures in isolated and narcolepsy-related REM sleep behaviour disorder: a preliminary study

Panagis Drakatos, Iain Duncan, Danielle Wasserman, Valentina Gnoni et autres

Background REM sleep behaviour disorder (RBD) is a prodrome of α -synucleinopathy, yet mechanistic pathways are unresolved. Narcolepsy type 1 with RBD (NT1-RBD) provides a human model of orexin deficiency. We tested whether REM motor semiology differs categorically between isolated RBD (iRBD) …

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Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan-NSAIDs Combinations in Individualized Treatment Plans

Peter J. Goadsby, Alexandra J. Sinclair, Shazia Afridi, Christian Lucas et autres

This opinion paper on the acute treatment of migraine addresses the definition and recognition of acute migraine attacks, highlighting the variety of symptoms and manifestations. It describes the available treatments and guidelines, noting significant country-specific variations. The paper also discusses the prescribers' …

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Vestibular migraine. Clinical and diagnostic challenges, and emerging therapeutic approaches

Maria Dolores Villar‐Martínez, Ahmed Abdalla, Peter J. Goadsby

PURPOSE OF REVIEW: Vestibular migraine (VM) is a prevalent yet underdiagnosed cause of vestibular symptoms, which overlaps with other vestibular and migraine-related conditions. This review focuses on detailed clinical phenomenology, alongside comorbidities, and the appraisal of emerging therapies. RECENT FINDINGS: Recent work …

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Early and Sustained Shift in Headache Day Frequency Following Eptinezumab Treatment in Adults With Migraine for Whom 2–4 Previous Preventive Treatments Have Failed: A Post Hoc Analysis of the Randomized DELIVER Trial

Cristina Tassorelli, Amaal J. Starling, Susanne F. Awad, Xin Ying Lee et autres

BACKGROUND: This post hoc analysis examined the reduction in monthly headache days (MHDs) by frequency category shifts and associated improvements following eptinezumab treatment. METHODS: The DELIVER trial evaluated eptinezumab in adults with migraine for whom 2-4 previous preventive treatments failed. During a …

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