Luísa Menezes Silva

Reconfiguração da imunidade inata e adaptativa em resposta à flutuação nutricional

Luísa Menezes Silva

Psoriasis-like skin inflammation drives an elongated mitochondrial network marked by functional failure in keratinocytes

Luís Eduardo Duarte Gonçalves, Anthony Gabry da Silveira, Luísa Menezes Silva, Bruno Ghirotto Nunes et autres

BACKGROUND: Psoriasis is characterized by a pathogenic, hyperproliferative state of keratinocytes. While inflammation is known to drive this proliferation and induce metabolic reprogramming to regulate immune effector functions, the specific mitochondrial and metabolic alterations in keratinocytes during psoriatic inflammation remain poorly understood. …

gb, br (code pays fourni par la source)

Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment

Loreana Sanches Silveira, Alexandre Abílio de Souza Teixeira, Luana Amorim Biondo, Luísa Menezes Silva et autres

Cancer is a global epidemic with increasing incidence, which needs continuous efforts to enhance treatment efficacy and reduce side effects. Our study focuses on the impact of doxorubicin, a widely used chemotherapeutic agent, on white adipose tissue (WAT) homeostasis and explores the …

gb (code pays fourni par la source)

Cisplatin Toxicity Causes Neutrophil-Mediated Inflammation in Zebrafish Larvae

Bárbara Nunes Padovani, Camila Morales, Laís Cavalieri Paredes, Mariana Abrantes do Amaral et autres

Cisplatin is an antineoplastic agent used to treat various tumors. In mammals, it can cause nephrotoxicity, tissue damage, and inflammation. The release of inflammatory mediators leads to the recruitment and infiltration of immune cells, particularly neutrophils, at the site of inflammation. Cisplatin …

br, us (code pays fourni par la source)

Efeito da via colinérgica sobre alterações celulares e metabólicas no tecido adiposo

Luísa Menezes Silva

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Effect of the cholinergic pathway in cellular and metabolic changes in the adipose tissue

Luísa Menezes Silva

A compreensão dos mecanismos que sustentam a homeostase metabólica e imunológica nos diferentes compartimentos do tecido adiposo é essencial uma vez que estes tecidos contribuem ativamente para a origem de distúrbios metabólicos. O controle da inflamação pela via colinérgica é um dos …