Zunjing Liu

Effects of human urinary kallidinogenase on early neurological improvement and functional outcomes in acute ischaemic stroke (TK-SPEED): protocol for a multi-centre, randomised, open-label, blinded-endpoint controlled study

Xiaowei Song, Zhongqi Qi, Ceshu Gao, Chenming Wei et autres

BACKGROUND: A considerable number of patients with acute ischaemic stroke (AIS) are ineligible for standard reperfusion therapy due to time window constraints and contraindications. Human urinary kallidinogenase (HUK), a tissue kallikrein, has been demonstrated to promote vasodilation and improve cerebral blood flow …

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Abdominal Adiposity and Lacunar Stroke: A Mendelian Randomization Mediation Study

Mengmeng Guo, Lu Cong, Zunjing Liu

Abstract Background Lacunar stroke accounts for approximately 25% of ischaemic strokes and is linked to metabolic and vascular risk factors. Abdominal adiposity, measured as waist-to-hip ratio adjusted for BMI (WHRadjBMI), is a heritable predictor of cerebrovascular disease independent of overall adiposity, but …

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Age-dependent associations of peripheral inflammatory biomarkers with cognition and brain structural abnormalities in patients with Alzheimer’s disease and Alzheimer’s disease-related mild cognitive impairment

Yida Wang, Min Cheng, Zunjing Liu

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative conditions. Chronic peripheral inflammation has been implicated in the pathophysiology of AD. Given their accessibility and cost-effectiveness, peripheral inflammatory biomarkers hold promise as potential indicators for AD. However, their associations with …

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Circulating Cytokines Mediate the Causal Relationship between Plasma Lipids and Migraine and its Subtypes: A Mediated Mendelian Randomization Study

Yating Han, Shicheng Lin, Guanglu Li, Mengmeng Guo et autres

INTRODUCTION: Migraine, a primary headache disorder, is the third disabling disease of neurological disorders worldwide. The pathological mechanism underlying migraine remains poorly understood. Lipid metabolism may be related to migraine pathophysiology. We aimed to investigate the causal relationship between plasma lipids and …

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Duration of diabetes, glycemic control and intracranial atherosclerotic plaque vulnerability

Qin Huang, Wei Liu, Lili Sun, Lei Liu et autres

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Impact of Previous Glycemic Control on High-Resolution MRI Plaque Characteristics and Stroke Mechanisms in Patients with Middle Cerebral Artery Atherosclerosis

Qin Huang, Wei Liu, Lei Liu, Shuo Zhang et autres

BACKGROUND AND PURPOSE: Although diabetes mellitus (DM) is a consistently documented risk factor for the plaque vulnerability, the effect of diabetes mellitus and glycemic control on the characteristics of intracranial plaques and stroke mechanism has yet to be explored. This study aimed …

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Lipoprotein(a) associates with high-resolution MRI-assessed intracranial plaque vulnerability and long-term stroke recurrence

Qin Huang, Lei Liu, Wei Liu, Shuo Zhang et autres

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Role of memantine in adult migraine: a systematic review and network meta-analysis to compare memantine with existing migraine preventive medications

Guanglu Li, Baoquan Qu, Tao Zheng, Shaojie Duan et autres

Background: While memantine has been considered a promising drug for migraine prevention, no conclusive evidence exists comparing its efficacy with other migraine-preventive medications. This network meta-analysis (NMA) aimed to access the effectiveness and acceptability of memantine and other guideline-recommended prophylactic agents for …

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Association between human herpes simplex virus and severe headache or migraine among aged 20–49 years: a cross-sectional study

Tao Zheng, Li Jiang, Guanglu Li, Na Zeng et autres

Background and purpose Previous studies have shown that human herpes simplex virus (HSV) infection may be associated with the onset of headache or migraine. We aimed to investigate the association between HSV infection and severe headache or migraine. Materials and methods The …

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Causal relationship between primary headache mediated by circulating cytokines and cerebral cortex structure: a mediation Mendelian randomization study

Tao Zheng, Na Zeng, Guanglu Li, Shicheng Lin et autres

Inflammation may be related to structural changes in the cerebral cortex. We aimed to explore whether cytokines mediate the link between these changes and primary headache. The summary statistics of genome-wide association study (GWAS) related to migraine and its subtypes, cluster headache …

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Characteristics of Atherosclerotic Plaques and Stroke Mechanism in Patients with Border-Zone Infarcts: A High-resolution Magnetic Resonance Imaging Study

Qin Huang, Lei Liu, Shuo Zhang, Yao Yu et autres

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Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study

Guanglu Li, Shaojie Duan, Tao Zheng, Tiantian Zhu et autres

Background: Migraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes. Methods: We conducted a two-sample …

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