Karen Alejandra Méndez‐Lara

An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target

Xiaomi Du, Karen Alejandra Méndez‐Lara, Siqi Hu, Rachel Y. Diao et autres

Peroxisome proliferator–activated receptor γ (PPARγ) is the pharmacologic target of thiazolidinediones, potent insulin sensitizers that prevent metabolic disease morbidity but are accompanied by adverse effects, such as weight gain, in part because of nonphysiologic transcriptional agonism. Using high-throughput genome engineering, we targeted …

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Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms

Jeimy Katherine Torres-Méndez, Julia Niño-Narvión, Patricia Martinez-Santos, Elena María Goretti Diarte-Añazco et autres

This study investigated the effect of nicotinamide (NAM) supplementation on the development of brain inflammation and microglial activation in a mouse model of type 1 diabetes mellitus. C57BL/6J male mice, which were made diabetic with five consecutive, low-dose (55 mg/kg i.p.) streptozotocin …

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Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases

Noemí Rotllán, Mercedes Camacho, Mireia Tondo, Elena M. G. Diarte‐Añazco et autres

Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular …

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Front Cover: Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging

Karen Alejandra Méndez‐Lara, Elisabeth Rodríguez‐Millán, David Sebastián, Rosi Blanco‐Soto et autres

Mol. Nutr. Food Res. 2021, 65, 2100111 DOI: 10.1002/mnfr.202100111 Artwork of representative resonance magnetic images illustrating reduced fat depots in diet-induced obese mice treated with nicotinamide. Nicotinamide supplementation increased uncoupling protein 1 abundance, NAD+ content and mitochondrial activity in white adipose tissue …

Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging

Karen Alejandra Méndez‐Lara, Elisabeth Rodríguez‐Millán, David Sebastián, Rosi Blanco‐Soto et autres

Scope Interventions that boost NAD+ availability are of potential therapeutic interest for obesity treatment. The potential of nicotinamide (NAM), the amide form of vitamin B3 and a physiological precursor of nicotinamide adenine dinucleotide (NAD)+, in preventing weight gain has not previously been …

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LDL receptor regulates the reverse transport of macrophage-derived unesterified cholesterol via concerted action of the HDL-LDL axis

Lídia Cedó, Jari Metso, David Santos, Annabel García‐León et autres

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Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

Karen Alejandra Méndez‐Lara, Nicole A Letelier, Núria Farré, Elena M. G. Diarte‐Añazco et autres

The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM …

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Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo

Lídia Cedó, Sara Fernández‐Castillejo, Laura Rubió, Jari Metso et autres

The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female …

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LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis

Lídia Cedó, Jari Metso, David Santos, Annabel García‐León et autres

RATIONALE: The HDL (high-density lipoprotein)-mediated stimulation of cellular cholesterol efflux initiates macrophage-specific reverse cholesterol transport (m-RCT), which ends in the fecal excretion of macrophage-derived unesterified cholesterol (UC). Early studies established that LDL (low-density lipoprotein) particles could act as efficient intermediate acceptors of …

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LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis Insight From Mouse Models

Lídia Cedó, Jari Metso, David Santos, Annabel García‐León et autres

Rationale: The HDL (high-density lipoprotein)-mediated stimulation of cellular cholesterol efflux initiates macrophage-specific reverse cholesterol transport (m-RCT), which ends in the fecal excret...

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Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo

Lídia Cedó, Sara Fernández‐Castillejo, Laura Rubió, Jari Metso et autres

The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female …

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Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases

Elena M. G. Diarte‐Añazco, Karen Alejandra Méndez‐Lara, Antonio Pérez, Núria Alonso et autres

Sphingolipids are key signaling molecules involved in the regulation of cell physiology. These species are found in tissues and in circulation. Although they only constitute a small fraction in lipid composition of circulating lipoproteins, their concentration in plasma and distribution among plasma …

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