Katia Fecchi

17β-Estradiol Modulates Cancer Cell–Fibroblast Communication via Autophagy-Mediated Extracellular Vesicle Secretion and Promotes Poor Prognosis in Non-Small Cell Lung Cancer

Rosa Vona, Camilla Cittadini, Barbara Ascione, Lucrezia Gambardella et autres

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Smoking is the primary etiological factor, but growing evidence suggests the involvement of estrogen in its development and progression, although its role remains unclear. This study explores: (i) the effects …

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IL ‐1β Upregulates PD ‐ L1 in Small Extracellular Vesicle of Endothelial Origin

Maria Cristina Gagliardi, Federica Felicetti, Lucia Bertuccini, Elena Ortona et autres

Programmed death ligand 1(PD-L1) is of significant importance in the regulation of immune cells, and its levels increase in response to inflammation in HUVECs. In this letter, we examined the expression of PD-L1 on small extracellular vesicles (sEVs) in human umbilical vein …

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Intraluminal vesicle trafficking is involved in the secretion of base excision repair protein APE1

Isabella Parolini, Monica Degrassi, Francesca Spadaro, Federica Caponnetto et autres

The apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is an essential enzyme of the base excision repair pathway of non-distorting DNA lesions. In response to genotoxic treatments, APE1 is highly secreted (sAPE1) in association with small-extracellular vesicles (EVs). Interestingly, its presence in the serum of …

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Author response for "Intraluminal vesicle trafficking is involved in the secretion of base excision repair protein APE1 "

Isabella Parolini, Monica Degrassi, Francesca Spadaro, Federica Caponnetto et autres

Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox

Daniela Peruzzu, Katia Fecchi, Giulietta Venturi, Maria Cristina Gagliardi

Mpox (monkeypox) is a zoonotic viral disease caused by the mpox virus (MPXV). Recently in 2022, a multi-country Mpox outbreak has determined great concern as the disease rapidly spreads. The majority of cases are being noticed in European regions and are unrelated …

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Inhibition of cholesterol transport impairs Cav‐1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells

Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro et autres

Caveolin-1 (Cav-1) is a fundamental constituent of caveolae, whose functionality and structure are strictly dependent on cholesterol. In this work the U18666A inhibitor was used to study the role of cholesterol transport in the endosomal degradative-secretory system in a metastatic human melanoma …

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Zika Virus Exploits Lipid Rafts to Infect Host Cells

Daniela Peruzzu, Antonello Amendola, Giulietta Venturi, Valeria de Turris et autres

Several flaviviruses such as Hepatitis C virus, West Nile virus, Dengue virus and Japanese Encephalitis virus exploit the raft platform to enter host cells whereas the involvement of lipid rafts in Zika virus–host cell interaction has not yet been demonstrated. Zika virus …

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Human Monocyte-Derived Dendritic Cells Are the Pharmacological Target of the Immunosuppressant Flavonoid Silibinin

Maria Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona et autres

Silibinin, a natural polyphenolic flavonoid, is known to possess anti-inflammatory, anticancer, antioxidant, and immunomodulatory properties. However, the effects of Silibinin on the maturation and immunostimulatory functions of human dendritic cells (DC) remain to be elucidated. In this study, we have attempted to …

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Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference?

Daniela Peruzzu, Maria Luisa Dupuis, Marina Pierdominici, Katia Fecchi et autres

Hypovitaminosis D is involved in various inflammatory, infectious and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Moreover, the active form of vitamin D, calcitriol, has been shown to modulate the immune response, playing an anti-inflammatory effect. However little is known …

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Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers

Maria Pagano, Daniela Peruzzu, Luca Busani, Marina Pierdominici et autres

BACKGROUND: Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress …

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Sex differences in antiviral immunity in SARS‐CoV‐2 infection: Mitochondria and mitomiR come into view

Elisabetta Iessi, Camilla Cittadini, Simona Anticoli, Katia Fecchi et autres

Mitochondria are multifaceted organelles representing the ‘powerhouse of cells’ for their function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in the regulation of innate and adaptive immune responses, including host defences against viruses, as well as in …

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Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets

Katia Fecchi, Simona Anticoli, Daniela Peruzzu, Elisabetta Iessi et autres

Coronaviruses are enveloped, single-stranded, positive-sense RNA viruses that can infect animal and human hosts. The infection induces mild or sometimes severe acute respiratory diseases. Nowadays, the appearance of a new, highly pathogenic and lethal coronavirus variant, SARS-CoV-2, responsible for a pandemic (COVID-19), …

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