Christina Thiede

Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome

Tim Fieblinger, Judith Rudolph, Kerstin Müller, Petra Friess et autres

models providing a valid strategy for identifying drug-repurposing candidates to treat PHTS patients.

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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A. Shivak et autres

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Meso scale discovery-based assays for the detection of aggregated huntingtin

Wolfgang Reindl, Barbara Baldo, Jana Felicitas Schulz, Isabell Janack et autres

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT (mHTT) protein is highly prone …

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B8 Ablation of p62 modulates levels of soluble and aggregated mutant huntingtin and delays end-stage disease in R6/2 mice

Kirupa Sathasivam, Casandra Gomez Paredes, Kirsten Kuhlbrodt, Christina Thiede et autres

Background N-terminal fragments of the mutant huntingtin (HTT) protein aggregate into oligomeric and fibrillary structures that can be detected as polyubiquitylated inclusion bodies in tissue sections from HD patients and mouse models of HD. Misfolded and aggregated proteins are degraded through two …

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B1 HTT CAG knock-in mice with pure and interrupted repeat tracts provide insight into the role of somatic expansion in HD pathogenesis

Vanessa C. Wheeler, Marina Kovalenko, James V. Giordano, Marissa A Andrew et autres

Background The expanded CAG repeat in the Huntington’s disease (HD) gene HTT is the major contributor to disease onset. The repeat also expands progressively in somatic cells, particularly in medium-spiny striatal neurons. Human and mouse genetic studies strongly support somatic expansion as …

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Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality

André Düselder, В. М. Фридман, Christina Thiede, Alice Wiesbaum et autres

The bipolar kinesin-5 motors are one of the major players that govern mitotic spindle dynamics. Their bipolar structure enables them to cross-link and slide apart antiparallel microtubules (MTs) emanating from the opposing spindle poles. The budding yeast kinesin-5 Cin8 was shown to …

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Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

Nikisha Carty, Nadège Berson, Karsten Tillack, Christina Thiede et autres

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. Major pathological hallmarks of HD include inclusions of mutant huntingtin (mHTT) protein, loss of neurons predominantly in the caudate nucleus, and atrophy …

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A Chimeric Kinesin-1 Head/Kinesin-5 Tail Motor Switches between Diffusive and Processive Motility

Christina Thiede, Stefan Lakämper, Alok D. Weßel, Stefanie D. Krämer et autres

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Single-molecule experiments with mitotic motor proteins

Christina Thiede

Die vorliegende kumulative Doktorarbeit\nbeinhaltet in fünf Kapiteln (Kapitel 2, 3, 4, und 5 bestehend aus\npublizierten Veröffentlichungen und Kapitel 6 bestehend aus einem\neingereichten Manuskript) neue Erkenntnisse über unterschiedlicher\nAspekte der Regulation von mitotischen kinesin-5 Motorproteinen.\nAußerhalb des Themas der kinesin-5-Regulation besteht Kapitel 7 aus\neiner publizierten …

Endoplasmic Reticulum Sorting and Kinesin-1 Command the Targeting of Axonal GABAB Receptors

Viviana Valdés, José Ignacio Valenzuela, Daniela Salas, Matías Jaureguiberry-Bravo et autres

In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength. Metabotropic γ amino-butyric acid (GABA) type B receptors (GABA(B)Rs) are neurotransmitter receptors that modulate synaptic transmission by …

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Neck-Linker Length Dependence of Processive Kinesin-5 Motility

André Düselder, Christina Thiede, Christoph F. Schmidt, Stefan Lakämper

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Regulation of bi-directional movement of single kinesin-5 Cin8 molecules

Christina Thiede, В. М. Фридман, Adina Gerson‐Gurwitz, Larisa Gheber et autres

Kinesin-5 mechanoenzymes drive mitotic spindle dynamics as slow, processive microtubule (MT)-plus-end directed motors. Surprisingly, the Saccharomyces cerevisiae kinesin-5 Cin8 was recently found to be bi-directional: it can move processively in both directions on MTs. Two hypotheses have been suggested for the mechanism …

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