Jon Peñarando

KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Immunotherapy has emerged as a revolutionary therapeutic approach to treat cancer showing remarkable clinical responses. However, its efficacy in solid tumours such as prostate cancer (PCa) remains very limited due to a highly immunosuppressive tumour immune microenvironment (TIME) that hampers cytotoxic T …

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Additional file 2 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 2: Supplemental Fig. 6: Source data for western blots shown in Fig. 5F, Supplemental Fig. 1H, 1L, 1J, 1W, 1Y.

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Additional file 1 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 1: Supplemental Fig. 1: KMT9 controls expression of PMN-MDSC-chemoattractants in PCa. A, Table depicting numbers and clinical features of human normal prostate and prostate tumour samples in the TCGA-PRAD cohort. B, Box-Whisker plots with min to max values showing KMT9β …

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Additional file 3 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 3.

de, fr (code pays fourni par la source)

Additional file 1 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 1: Supplemental Fig. 1: KMT9 controls expression of PMN-MDSC-chemoattractants in PCa. A, Table depicting numbers and clinical features of human normal prostate and prostate tumour samples in the TCGA-PRAD cohort. B, Box-Whisker plots with min to max values showing KMT9β …

de, fr (code pays fourni par la source)

Additional file 3 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 3.

de, fr (code pays fourni par la source)

Additional file 2 of KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Jon Peñarando, Dominica Willmann, Manuela Sum, Yanhan Jia et autres

Supplementary Material 2: Supplemental Fig. 6: Source data for western blots shown in Fig. 5F, Supplemental Fig. 1H, 1L, 1J, 1W, 1Y.

de, fr (code pays fourni par la source)

Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells

Laura Maria Lopez-Sanchez, Rafael Mena‐Osuna, Silvia Guil‐Luna, Ana Mantrana et autres

es (code pays fourni par la source)

SWATH‐based proteomics reveals processes associated with immune evasion and metastasis in poor prognosis colorectal tumours

Laura Maria Lopez-Sanchez, Rafael Jiménez‐Izquierdo, Jon Peñarando, Rafael Mena‐Osuna et autres

Newly emerged proteomic methodologies, particularly data-independent acquisition (DIA) analysis-related approaches, would improve current gene expression-based classifications of colorectal cancer (CRC). Therefore, this study was aimed to identify protein expression signatures using SWATH-MS DIA and targeted data extraction, to aid in the classification …

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Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Laura Casares, Víctor Atencio García, Martín Garrido‐Rodríguez, Estrella Millán et autres

Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical benefits of CBD in humans have been extensively demonstrated, the …

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Immunomodulatory roles of nitric oxide in cancer: tumor microenvironment says “NO” to antitumor immune response

Jon Peñarando, Enrique Aranda, Antonio Rodríguez‐Ariza

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Nitric Oxide Scavenging-Based Therapies for Targeting Colorectal Cancer

Jon Peñarando, Kevin Myant, Enrique Aranda, Antonio Rodríguez‐Ariza

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