Nikola Nedeljković

From Painkillers to Antidiabetics: Structural Modification of NSAID Scaffolds for Drug Repurposing

Anđela Gogić, Miloš Nikolić, Nikola Nedeljković, Nebojša Zdravković et autres

The treatment of diabetes in the modern era, with its growing patient population, represents a significant challenge due to the wide range of adverse effects associated with medications that target complex biochemical processes. Consequently, researchers are investigating the hypoglycemic potential of existing …

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In Vitro Pharmacokinetic Profiling of Thiourea Derivatives of Naproxen With Anti‐Inflammatory and Anticancer Activity

Nikola Nedeljković, Vladimir Dobričić, Marina Vesović, Ratomir Jelić et autres

Pharmacokinetic deficiencies account for nearly 40% of clinical drug candidate failures, emphasising the importance of early in vitro evaluation. Following the 3Rs principle, this study assessed the in vitro pharmacokinetic properties of thiourea derivatives of naproxen (1-14). Permeability assessment using the parallel …

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In silico evaluation of the antibacterial and antiviral potential of nusbiarylin derivatives

Ognjen Milić, Nikola Nedeljković, Miloš Nikolić

Antimicrobial resistance and chronic viral infections are major challenges in contemporary medicine. This in silico study evaluated the dual inhibitory potential of 16 designed nusbiarylin derivatives against two clinically relevant enzymatic targets: Escherichia coli (E. coli) RNA polymerase (RNAP) and hepatitis C …

Integrated RP-TLC and RP-HPLC assessment of lipophilicity of naproxen-based thiourea derivatives with anti-inflammatory and anticancer potential

Stefan Gavrilović, Nikola Nedeljković, Vladimir Dobričić, Marina Vesović et autres

Abstract Lipophilicity is a fundamental physicochemical property in drug discovery and development, critically influencing pharmacokinetic behavior and biological activity. In previous studies, fourteen thiourea derivatives of naproxen (compounds 1 – 14 ) were synthesized and evaluated for COX-2 and 5-LOX inhibitory activity, …

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Alkyl Derivatives of 2‐Mercaptobenzoic Acid Exhibit Dual Anti‐Inflammatory and Antioxidant Activities: Combined In Vivo, In Vitro, and In Silico Evaluation

Nikola Nedeljković, Marina Nikolić, Miloš Nikolić, Jovana Bradić et autres

Abstract This research aimed to investigate the key mechanisms underlying anti‐inflammatory and antioxidative effects of 2‐mercaptobenzoic acid derivatives, using in vivo, in vitro, and in silico approach. The anti‐inflammatory activity was examined using the carrageenan‐induced acute inflammation model. A total of 144 …

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Silver(I) Complexes Bearing S-Alkyl Thiosalicylic Acid Derivatives: DNA/BSA Binding and Antitumor Activity In Vitro and In Vivo

Jovana Marinković, Milena Jurišević, Marina Jovanović, Miloš Milosavljević et autres

Background/Objectives: In recent years, silver complexes have shown strong antibacterial, antifungal, and antitumor activity with high selectivity toward cancer cells. Their cytotoxic effects are mainly linked to apoptosis induction, DNA damage, and enzyme inhibition, while the antitumor activity of silver(I) complexes with …

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Targeting Oxidative Stress and Inflammation with Vitis vinifera Leaf Extract: A Combined Experimental and Computational Pharmacological Study

Marina Nikolić, Ivan Srejović, Nikola Nedeljković, Marko Karovic et autres

Objectives: Our study aimed to examine the antioxidative and anti-inflammatory potential of the lyophilized aqueous leaf extract of Vitis vinifera. Methods: The antioxidant capacity of the extract was evaluated using the DPPH and FRAP assays. The in vivo phase of the study …

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The Therapeutic Potential of Galium verum for Psoriasis: A Combined Phytochemical, In Silico, and Experimental Approach

Branislava Daskalovic, Vladimir Jakovljević, Sergej Bolevic, Marijana Andjić et autres

Psoriasis is a chronic inflammatory skin disorder involving oxidative stress and immune dysregulation. Given the limitations and adverse effects of conventional therapies, interest in natural treatments with anti-oxidant and immunomodulatory properties is increasing. This study aimed to comprehensively evaluate the therapeutic potential …

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Analysis of the Lipophilicity and HSA Binding Profile of Biologically Relevant 2‐Mercaptobenzoic Acid Derivatives

Miloš Nikolić, Ratomir Jelić, Nikola Nedeljković, Gordana P. Radić et autres

ABSTRACT One of the key factors determining a compound's distribution, metabolism, and therapeutic properties is its binding affinity to human serum albumin (HSA). This study investigated the binding interaction between potential biologically active S ‐alkyl (methyl‐[L1], ethyl‐[L2], propyl‐[L3], butyl‐[L4], and benzyl‐[L5]) derivatives …

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From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives

Marko Karović, Miloš Nikolić, Nikola Nedeljković, Marina Vesović et autres

In the present study, five novel dexketoprofen amide derivatives with a free carboxyl group in their side chains were synthesized. The in vivo anti-inflammatory potential of dexketoprofen derivatives was evaluated using a carrageenan-induced paw edema model of acute inflammation. Additionally, the local …

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Medicinal Chemistry Insights in Neuronal Nitric Oxide Synthase Inhibitors Containing Nitrogen Heterocyclic Compounds: A Mini Review

Dijana N. Bojović, Miloš Nikolić, Nikola Nedeljković, Marina Vesović et autres

Many scientific reports over the last two decades have focused on the discovery and development of novel nNOS inhibitors. The structural identity of isoforms, bioavailability, pharmacokinetic, and safety profile issues remain major obstacles in the discovery of more potent and selective nNOS …

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Potentilla tormentilla Extract Loaded Gel: Formulation, In Vivo and In Silico Evaluation of Anti-Inflammatory Properties

Jovana Bradić, Anica Petrović, Miloš Nikolić, Nikola Nedeljković et autres

The objective of the study was to develop a novel topical gel by mixing Potentilla tormentilla ethanolic extract, thermosensitive poloxamer 407, and carbomer 940 and evaluating its stability and rheological behavior. The irritation potential of the gel was evaluated in accordance with …

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