Xiaocong Pang

Butyric Acid-Modified m-P14 Peptide Ameliorates Anti-Glomerular Basement Membrane Disease

Nan Jiang, Yan-lun Gu, Huang Kuang, Zhao Cui et autres

The non-collagenous domain 1 of the α3 chain of type IV collagen (α3(IV)NC1) is the primary autoantigen in anti-glomerular basement membrane (anti-GBM) disease. We previously developed a modified antigen-specific peptide, m-P14, derived from the nephritogenic epitope α3127–148, which ameliorated experimental anti-GBM nephritis. …

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Engineering NK cell membrane-camouflaged copper-BODIPY nanoassembly to synergize dual-phototherapy and cuproptosis for enhanced antitumor immunity

Xuya Yu, Yushi Zhang, Zhuona Rong, Xueping Li et autres

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Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

Lin Chen, Yanlun Gu, Yuke Chen, Yu Wei et autres

Prostate cancer (PCa) diagnosis is hampered by the limited specificity of current methods, necessitating more reliable biomarkers. To identify causal protein biomarkers and therapeutic targets in humans, we conducted a proteome-wide Mendelian randomization (MR) study. We first performed a meta-analysis of two …

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Author response: Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

Chen Lin, Yanlun Gu, Yuke Chen, Wei Yu et autres

The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.

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Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

Lin Chen, Gu Yanlun, Yu Wei, Ying Zhou et autres

Abstract Background Due to the limitations in specificity of current diagnostic methods for prostate cancer (PCa), more reliable biomarkers are needed to explore for improving early detection. Plasma proteins represent a promising source of biomarkers, therefore understanding the causal relationships between specific …

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Author response: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

Lin Chen, Gu Yanlun, Wei Yu, Ying Zhou et autres

The Safety of Cadonilimab: A Systematic Review and Single‐Arm Meta‐Analysis

Zhuo Zhang, Jiao Yu, Zhiqi Zhang, Qianxin Liu et autres

INTRODUCTION: Cadonilimab (AK104) is a bispecific antibody that simultaneously targets programmed cell death-1 and cytotoxic T-lymphocyte antigen-4. It has received approval for the treatment of cervical cancer and gastric/gastroesophageal junction cancer. This meta-analysis aims to assess cadonilimab's safety profile. METHODS: A systematic …

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Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

Lin Chen, Xiaocong Pang

Prostate cancer (PCa) diagnosis is hampered by the limited specificity of current methods, necessitating more reliable biomarkers. To identify causal protein biomarkers and therapeutic targets in humans, we conducted a proteome-wide Mendelian randomization (MR) study. We first performed a meta-analysis of two …

cn (code pays fourni par la source)

Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

Lin Chen, Rong Zhuona, Gu Yanlun, Yu Wei et autres

Abstract Background Due to the limitations in specificity of current diagnostic methods for prostate cancer (PCa), more reliable biomarkers are needed to explore for improving early detection. Plasma proteins represent a promising source of biomarkers, therefore understanding the causal relationships between specific …

cn (code pays fourni par la source)

Author response: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

Lin Chen, Rong Zhuona, Gu Yanlun, Wei Yu et autres

Due to the limitations in specificity of current diagnostic methods for prostate cancer (PCa), more reliable biomarkers are needed to explore for improving early detection. Plasma proteins represent a promising source of biomarkers, therefore understanding the causal relationships between specific plasma proteins …

Systematic Characterisation and Analysis of Lysyl Oxidase Family Members as Drivers of Tumour Progression and Multiple Drug Resistance

Hongjin Liu, Xiaojiao Sun, Bingqi Dong, Jixin Zhang et autres

The intricacies of tumour microenvironment, particularly the extracellular matrix (ECM), underscore its pivotal function in modulating tumour progression and drug resistance. Among the key regulators of ECM remodelling and homeostasis, the lysyl oxidases (LOXs) emerge as promising therapeutic targets of tumour treatment. …

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Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer via Regulating PI3K/AKT/NFκB Pathway and Tumor‐Associated Macrophage

Xiaojiao Sun, Junling Zhang, Bingqi Dong, Qingqing Xiong et autres

Liver metastasis is the major cause of death in colorectal cancer (CRC) due to the lack of effective treatment. To explore novel drivers of CRC liver metastasis, the transcriptomes of primary paracancerous, colorectal tumors and metastases from human patients are profiled. It …

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