Shaoliang Duan

Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-piperazinyl −6,14-endoethano-tetrahydronorthebaines

Shaoliang Duan, S. Hu, Yun Fang, Min Liu et autres

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Gynostemma pentaphyllum-derived extracellular vesicles alleviate skin aging by destabilizing STING

Dong Wang, Shaoliang Duan, Yujuan Fan, Tongqing Chen et autres

Skin aging represents a multifaceted degenerative process that predisposes to dermatological pathologies, including infections, dermatitis, and malignancies, causing great physical and psychological distress to patients. Conventional therapies, including topical antioxidants and sunscreens, have shown limited efficacy with safety concerns that continue to …

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Structure-activity relationship of N-cyclopropylmethyl-7α-(m-methylaminophenyl)-6,14-endoethano-northebaine derivatives as G-protein-biased KOR-selective agonists

Siyuan Tang, Jiangwen Gui, Yingjie Lan, Panwen Liu et autres

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Correction to “Structure–Activity Relationship of N -Cyclopropylmethyl-7α-[ para -(arylcarboxamido)phenyl]-6,14- endo ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists”

Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui et autres

Design, synthesis, and biological activity of novel para-substituted phenylamino and phenyl derivatives of northebaine as selective delta opioid receptor agonists

Denggao Zhang, Jiangwen Gui, Linghui Kong, Chuyuan Hu et autres

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Structure–Activity Relationship of N -Cyclopropylmethyl-7α-[ para -(arylcarboxamido)phenyl]-6,14- endo ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists

Linghui Kong, Denggao Zhang, Jiangwen Gui, Baiyu Chen et autres

Abstract Research on KOR agonists with reduced central nervous system side effects represents a significant area in analgesic studies. Herein, a structure–activity relationship analysis was performed for a series of N-cyclopropylmethyl-7α-[para-(arylcarboxamido)phenyl]-6,14-endoethano-tetrahydronorthebaines. Several highly selective and potent KOR agonists have been identified. Notably, …

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Design, synthesis and biological evaluation of (E)-4-(2-((1H-indol-5-yl) methylene) hydrazineyl)-5,6,7,8-tetrahydropyrido [4′,3′:4,5] thieno[2,3-d] pyrimidine derivatives as Arf1-GEFs inhibitors for the treatment of colon cancer

Ning Li, Chenfei Luo, Yu‐Fan Liu, Shaoliang Duan et autres

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Structure–activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities

Siyuan Tang, S. Hu, Linghui Kong, Jiangwen Gui et autres

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Design, Synthesis, and Biological Activity of Novel Para-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethenotetrahydronorthebaines as Selective Delta Opioid Receptor Agonists

Denggao Zhang, Jiangwen Gui, Linghui Kong, Chuyuan Hu et autres

cn (code pays fourni par la source)