Robert L. Burton

A scoping review of human digital twins in healthcare applications and usage patterns

Brant H. Tudor, Ryan Shargo, Geoffrey Gray, Jamie L. Fierstein et autres

Digital twins have become increasingly popular across various industries as dynamic virtual models of physical systems. In healthcare, Human Digital Twins (HDTs) serve as virtual counterparts to patients. According to the National Academies of Sciences, Engineering, and Medicine (NASEM), a digital twin …

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Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies

Weifeng Xu, Joseph M. Antonello, Jennifer L. Nguyen, Chaoyang Ma et autres

BACKGROUND: The opsonophagocytic assay (OPA) is the gold standard for measuring functional antibody responses to bacterial vaccines. However, antibody-independent bactericidal activities, such as those by antibiotics, could contribute to the killing and thus inflate the measured antibody titer. Because of this, an …

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Correction: Feemster et al. Implications of Cross-Reactivity and Cross-Protection for Pneumococcal Vaccine Development. Vaccines 2024, 12, 974

Kristen A. Feemster, William P. Hausdorff, Natalie Banniettis, Heather Loryn Platt et autres

The authors would like to make the following corrections to this published paper [...].

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Humoral immune response to 10-valent pneumococcal conjugate vaccine (PCV10) in individuals with type 2 diabetes mellitus

Izaz Ahmad, Robert L. Burton, Rozina Arshad, Bilal Bin Younis et autres

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Implications of Cross-Reactivity and Cross-Protection for Pneumococcal Vaccine Development

Kristen A. Feemster, William P. Hausdorff, Natalie Banniettis, Heather Loryn Platt et autres

Pneumococcal vaccines are a cornerstone for the prevention of pneumococcal diseases, reducing morbidity and mortality in children and adults worldwide. Pneumococcal vaccine composition is based on the polysaccharide capsule of Streptococcus pneumoniae, which is one of the most important identified contributors to …

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Naturally acquired antibodies against 4 Streptococcus pneumoniae serotypes in Pakistani adults with type 2 diabetes mellitus

Izaz Ahmad, Robert L. Burton, Moon H. Nahm, Hafiz Gohar Ejaz et autres

Immune response elicited during pneumococcal carriage has been shown to protect against subsequent colonization and infection by Streptococcus pneumoniae. The study was designed to measure the baseline serotype-specific anti-capsular IgG concentration and opsonic titers elicited in response to asymptomatic carriage in adults …

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Piloting wastewater-based surveillance of norovirus in England

David I. Walker, Jessica Witt, Wayne G. Rostant, Robert L. Burton et autres

Wastewater-based epidemiology (WBE) gained widespread use as a tool for supporting clinical disease surveillance during the COVID-19 pandemic. There is now significant interest in the continued development of WBE for other pathogens of clinical significance. In this study, approximately 3,200 samples of …

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A systematic review of online team based learning approaches in health professional education

Robert L. Burton, Ursula Kellett, Martha Mansah, Deepa Sriram

AIMS AND OBJECTIVES: The purpose of this study was to systematically review studies related to the use of online Team Based Learning (TBL) platforms with a focus on health professional education. The objectives were to identify best practices, highlight what technological platforms …

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Piloting wastewater-based surveillance of norovirus in England

David I. Walker, Jessica Witt, Wayne G. Rostant, Robert L. Burton et autres

Abstract Wastewater-based epidemiology (WBE) gained widespread use as a tool for supporting clinical disease surveillance during the COVID-19 pandemic. There is now significant interest in the continued development of WBE for other pathogens of clinical significance. In this study, approximately 3,200 samples …

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The 15-valent pneumococcal conjugate vaccine V114 induces cross-reactive antibodies against pneumococcal serotype 6C

Yaru Shi, Katrina M. Nolan, Robert L. Burton, Tulin Shekar et autres

Pneumococcal serogroups consist of structurally related serotypes, and serotype-specific antibodies can cross-react against other serotypes within the same serogroup. Cross-reactivity of vaccine-induced serotype 6A antibodies, and, to a lesser extent, serotype 6B antibodies, to serotype 6C has been demonstrated following receipt of …

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Application and evaluation of interactive virtual technologies in nursing students’ learning and clinical skills assessment. A mixed methods study

Eileen Therese Grafton, Robert L. Burton, Gary Dean Grant, Daniel Della-Bosca et autres

Background: During the 2020 iteration of a Bachelor of Nursing Clinical Health Assessment skills course delivered in Singapore, the sudden cancellation of all face-to-face classes due to the pandemic resulted in innovative strategies being quickly created to enable students to successfully complete …

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Development and operationalisation of a mixed reality interactive virtual patient application for online nursing Objective Clinical Examinations

Eileen Therese Grafton, Robert L. Burton, Gary Dean Grant, Daniel Della-Bosca et autres

During the 2020 iteration of a Bachelor of Nursing Clinical Health Assessment skills course delivered in Singapore, the sudden cancellation of all face-to-face classes due to the COVID-19 pandemic resulted in innovative strategies being required and quickly created to enable students to …

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