J. Marina Yoder

Data and code from: Paradoxical Th1 activation and CTLA-4 exhaustion is beneficial during latent cryptococcosis

Minna Ding, Jenny Drnevich, J. Marina Yoder, Eric Dang et autres

Cryptococcus neoformans is the predominant causative agent of cryptococcal meningitis in immunocompromised individuals. Conversely, in immunocompromised individuals, C. neoformans establishes a latent pulmonary infection characterized by a paucity of clinical symptoms. Using a mouse inhalation model of latent C. neoformans infection, we …

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Author Correction: Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans

Katrina M. Jackson, Thomas J. Y. Kono, Jovany J. Betancourt, Yina Wang et autres

In the acknowledgements section the following grant number ‘R01AI176922’ provided by the Nation Institute of Health grants was omitted from the acknowledgements section. The original article has been corrected.

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Erratum for Betancourt et al., “Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases”

Jovany J. Betancourt, Minna Ding, J. Marina Yoder, Issa Mutyaba et autres

Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases

Jovany J. Betancourt, Minna Ding, J. Marina Yoder, Issa Mutyaba et autres

ABSTRACT Cryptococcus neoformans is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent …

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Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases

Jovany J. Betancourt, Minna Ding, J. Marina Yoder, Issa Mutyaba et autres

ABSTRACT Cryptococcus neoformans is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent …

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Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans

Katrina M. Jackson, Thomas J. Y. Kono, Jovany J. Betancourt, Yina Wang et autres

Studies across various pathogens highlight the importance of pathogen genetic differences in disease manifestation. In the human fungal pathogen Cryptococcus neoformans, sequence type (ST) associates with patient outcome. We performed a meta-analysis of four genomic studies and identified overlapping gene regions associated …

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The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G 2 Arrest in Cryptococcus

Sophie Altamirano, Zhongming Li, Man Shun Fu, Minna Ding et autres

Dysregulation of the cell cycle underlies many human genetic diseases and cancers, yet numerous organisms, including microbes, also manipulate the cell cycle to generate both morphologic and genetic diversity as a natural mechanism to enhance their chances for survival. The eukaryotic pathogen …

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The cyclin Cln1 controls polyploid titan cell formation following a stress-induced G2 arrest in Cryptococcus

Sophie Altamirano, Zhongming Li, Man Shun Fu, Minna Ding et autres

Abstract The pathogenic yeast Cryptococcus neoformans produces polyploid titan cells in response to the host lung environment that are critical for host adaptation and subsequent disease. We analyzed the in vivo and in vitro cell cycles to identify key aspects of the …

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ATI-2307 Exhibits Equivalent Antifungal Activity in Cryptococcus neoformans Clinical Isolates With High and Low Fluconazole IC50

Elliot S. Gerlach, Sophie Altamirano, J. Marina Yoder, Tony Luggya et autres

Half maximal inhibitory concentrations (IC 50 ) to the experimental drug ATI-2307 and complete inhibition (IC 90 ) of the common clinically used antifungal drug amphotericin B were determined by microbroth dilution assay for a collection of 69 clinical isolates of Cryptococcus …

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The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms

William C. Engeland, Logan Massman, Shubhendu Mishra, J. Marina Yoder et autres

The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock …

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Phase-Dependent Shifting of the Adrenal Clock by Acute Stress-Induced ACTH

William C. Engeland, J. Marina Yoder, Carley A. Karsten, Paulo Kofuji

The adrenal cortex has a molecular clock that generates circadian rhythms in glucocorticoid production, yet it is unclear how the clock responds to acute stress. We hypothesized that stress-induced ACTH provides a signal that phase shifts the adrenal clock. To assess whether …

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Chronic subordination stress phase advances adrenal and anterior pituitary clock gene rhythms

Maria Razzoli, Carley A. Karsten, J. Marina Yoder, Alessandro Bartolomucci et autres

Circadian rhythms in glucocorticoids are the product of interactions between the hypothalamic-pituitary-adrenal (HPA) axis and the mammalian clock gene system. The adrenal clock can generate the glucocorticoid rhythm that in turn synchronizes other peripheral clocks to maintain homeostasis. Stress acutely activates and …

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