Aruna Gorusupudi

Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function

Zhihong Yang, Aruna Gorusupudi, Todd A. Lydic, Anupam K. Mondal et autres

studies demonstrated that the VLCPUFA-oil and chemically synthesized C24:5 are potent agonists for PPARs. The multiple potential beneficial effects of fish oil-derived VLCPUFAs on cardiometabolic risk and eye health in mice support future efforts to develop VLCPUFA-oil into a supplemental therapy.

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Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI

Binxing Li, Evan W. George, Preejith Vachali, Fu‐Yen Chang et autres

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Role of VLC-PUFAs in Retinal and Macular Degeneration

Aruna Gorusupudi, Uzoamaka Nwagbo, Paul S. Bernstein

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Influence of very-long-chain polyunsaturated fatty acids on membrane structure and dynamics

Victoria Cheng, Rameshu Rallabandi, Aruna Gorusupudi, Steven Lucas et autres

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Extraction, detection, and imaging of the macular carotenoids

Binxing Li, Aruna Gorusupudi, Ranganathan Arunkumar, Paul S. Bernstein

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HDL is the primary transporter for carotenoids from liver to retinal pigment epithelium in transgenic ApoA-I/Bco2 mice

Binxing Li, Preejith Vachali, Fu‐Yen Chang, Aruna Gorusupudi et autres

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Association of carotenoid status between mothers and infants in the Lutein and Zeaxanthin in Pregnancy (L-ZIP) clinical trial

Emmanuel Kofi Addo, Aruna Gorusupudi, Paul S. Bernstein

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Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4/Bco2 double knockout mice

Ranganathan Arunkumar, Aruna Gorusupudi, Binxing Li, J. David Blount et autres

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The Lutein and Zeaxanthin in Pregnancy (L-ZIP) study—carotenoid supplementation during pregnancy: ocular and systemic effects—study protocol for a randomized controlled trial

Emmanuel Kofi Addo, Aruna Gorusupudi, Susan Allman, Paul S. Bernstein

BACKGROUND: Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), collectively called the macular pigment (MP), are dietary carotenoids that preferentially localize in the macula of the human eye. MP protects the macula from photo-oxidative damage and enhances visual function. Inadequate maternal intake of …

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Retinal bioavailability and functional effects of a synthetic very-long-chain polyunsaturated fatty acid in mice

Aruna Gorusupudi, Rameshu Rallabandi, Binxing Li, Ranganathan Arunkumar et autres

Significance Very-long-chain polyunsaturated fatty acids (VLC-PUFAs) longer than 26 carbons are not present in normal vertebrate diets, yet they are uniquely found in the retina and a few other tissues, implying physiological importance of their biosynthesis from shorter-chain dietary precursors via the …

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The synthesis of the very long chain polyunsaturated fatty acid (VLC-PUFA) 32:6 n-3

Alexander Wade, Rameshu Rallabandi, Steven Lucas, Catrina Oberg et autres

This article describes the synthesis of VLC-PUFA 32:6 n-3, D2-labeled 32:6 n-3, and the uptake of 32:6 n-3 into mouse retinal tissue.

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Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension

Mónika Lakk, Grace F. Hoffmann, Aruna Gorusupudi, Eric Enyong et autres

Despite the association of cholesterol with debilitating pressure-related diseases such as glaucoma, heart disease, and diabetes, its role in mechanotransduction is not well understood. We investigated the relationship between mechanical strain, free membrane cholesterol, actin cytoskeleton, and the stretch-activated transient receptor potential …

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