Tiffany Chu

Conserved tripartite tail proteins mediate virophage-host interactions through Synechococcus lipopolysaccharide binding

Tiffany Chu, Qian Wang, Chao-Yuan Hu, Bo Li et autres

ABSTRACT Virophages are small double-stranded DNA viruses that parasitize giant viruses and play crucial roles in microbial ecosystem dynamics. In this study, we investigate three evolutionarily conserved tail proteins in Dishui Lake Virophage 2 (DSLV2) that exhibit significant structural homology to the …

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Hypothyroidism and Degenerative Spine Disease: A Literature Review

Vikram Murugan, Tiffany Chu, Munira Ali, Omar S. Akbik

Hypothyroidism is an increasingly prevalent endocrine disorder, with recent U.S. estimates approaching 11.7%. While hypothyroidism has been suggested as a risk factor in spinal surgery outcomes, its prevalence and association with degenerative spine disease remain underexplored. To address this gap, we conducted …

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Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

Nicholas R. Franich, Miriam A. Hickey, Chunni Zhu, Georgina F Osborne et autres

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse …

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Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis

Hisashi Koide, Kenn Holmbeck, Julian C. Lui, Xiaoxiao Guo et autres

Mechanical stimulation is crucial to bone growth and triggers osteogenic differentiation through a process involving Rho and protein kinase A. We previously cloned a gene (AKAP13, aka BRX) encoding a protein kinase A-anchoring protein in the N-terminus, a guanine nucleotide-exchange factor for …

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Tissue-specific knockout of A-kinase anchoring protein 13 (AKAP13) – a potential murine model for polycystic ovarian syndrome

Kate Devine, Paul H. Driggers, Tiffany Chu, Alan H. DeCherney et autres

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