Mitch C. Johnson

Soil Nitrogen Fertility Influences the Growth and Yield of American Elderberry but Is Less Impactful than Genotype and Environment on Other Horticultural Characteristics

Andrew L. Thomas, George Edwin Rottinghaus, Matheus Dela Libera Tres, Patrick L. Byers et autres

A long-term horticultural experiment was conducted at two geographically distinct sites in southern Missouri in 2011–15 to study the response of American elderberry [ Sambucus nigra (L.) subsp. canadensis (L.) Bolli] to various soil nitrogen (N) fertilizer levels. Three commercially available elderberry …

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Soil nutrient amendment increases the potential for inter-kingdom resource competition among foliar endophytes

Zoe A. Hansen, Michael R. Fulcher, Nicholas Wornson, S. Spawn et autres

Abstract Foliar endophytes play crucial roles in large-scale ecosystem functions such as plant productivity, decomposition, and nutrient cycling. While the possible effects of environmental nutrient supply on the growth and carbon use of endophytic microbes have critical implications for these processes, these …

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Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

Erin Touchette, Maria C. Bates, Mitch C. Johnson, Tracy C O'Brien et autres

Humanized liver chimeric mice (PXB-mice) are generated by the transplantation of human hepatocytes into mice that have severe combined immunodeficiency and express an albumin-promoted urokinase-type plasminogen activator (cDNA-uPA/SCID) transgene. Human hepatocytes cannot synthesize ascorbic acid (AA; commonly called vitamin C) and humans …

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Abstract 1057: Significant efficacy demonstrated with the combination of ulixertinib (ERK1/2 inhibitor) and CDK4/6 inhibitors in MAPK altered models

Brian Corgiat, Justin Davis, David A. Sorrell, Mitch C. Johnson et autres

Abstract Ulixertinib (BVD-523) is a first-in-class small molecule inhibitor of ERK1/2 currently being investigated in several oncology clinical trials, both as a single agent and in combination with other anti-cancer therapeutics. Palbociclib and ribociclib are FDA approved orally active, potent, and highly …

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Effects of Porous versus Solid Inserts Pertaining to Instability Mitigation in Lean Direct Injection Combustion

Mitch C. Johnson, Ashley James, Ajay Kumar Agrawal

View Video Presentation: https://doi.org/10.2514/6.2022-2349.vid Lean direct injection (LDI) is an emerging combustion strategy to meet the increasingly stringent emissions requirements for carbon monoxide, nitric oxide, soot, and unburned hydrocarbons for aviation gas turbines. The LDI process is designed such that the fuel-air …

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Correction to: Network structure of resource use and niche overlap within the endophytic microbiome

Matthew J. Smith, Zewei Song, S. Spawn, Zoe A. Hansen et autres

Authors and Affiliations Department of Veterinary Population Medicine, University of Minnesota, St Paul, MN, USA Matthew Michalska-Smith Department of Plant Pathology, University of Minnesota, St Paul, MN, USA Matthew Michalska-Smith, Zewei Song & Linda L. Kinkel Department of Geography, University of Wisconsin, …

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Network structure of resource use and niche overlap within the endophytic microbiome

Matthew J. Smith, Zewei Song, S. Spawn, Zoe A. Hansen et autres

Endophytes often have dramatic effects on their host plants. Characterizing the relationships among members of these communities has focused on identifying the effects of single microbes on their host, but has generally overlooked interactions among the myriad microbes in natural communities as …

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Cyanogenic Glycoside Analysis in American Elderberry

Michael K. Appenteng, Ritter Krueger, Mitch C. Johnson, Harrison Ingold et autres

Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following enzymatic hydrolysis causing potential toxicity issues. The presence of CNGs in American …

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Uncovering the Potential of Peabody's Hidden North River: A Greenway for Social and Ecological Connectivity

Mitch C. Johnson

Project Goal Demonstrating the opportunity to strengthen both urban and ecological qualities, this project has the goal to transform an old industrial corridor in downtown Peabody into a green corridor integrating stormwater management, habit restoration, recreational, and catalyst for urban development.\nThe site’s …

Discriminant Analyses of the Polyphenol Content of American Elderberry Juice from Multiple Environments Provide Genotype Fingerprint

Mitch C. Johnson, Matheus Dela Libera Tres, Andrew L. Thomas, George Edwin Rottinghaus et autres

The cultivation of American elderberry (Sambucus nigra subsp. canadensis) continues to increase as the use of this botanical has expanded. Elderberries contain a variety of polyphenols, including anthocyanins, which have purported health benefits. However, information is lacking regarding the impact of environmental, …

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Comparison of Commercially Available and Synthesized Titania Nano‐Additives in Composite HTPB/AP Propellant

Andrew R. Demko, Tyler Allen, James Chris Thomas, Mitch C. Johnson et autres

Abstract This study presents a comparison of commercially available titania nano‐particles produced using electric wire explosion with nano‐particles manufactured by the authors using a sol‐gel synthesis process. For the present study, 20‐nm titania was purchased off‐the‐shelf. It was determined to be rough …

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LC-MS/MS method development for quantification of bioactive compounds in elderberry and garlic botanicals

Mitch C. Johnson

Dissertation supervisor: Dr. C. Michael Greenlief.