Oleg Oszurek

Correction to: Survival from breast cancer in women with a BRCA2 mutation by treatment

D. Gareth Evans, Kelly‐Anne Phillips, Roger Laughlin Milne, Robert Fruscio et autres

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The impact of oophorectomy on survival from breast cancer in patients with CHEK2 mutations

Joanna Tomiczek‐Szwiec, Marek Szwiec, Michał Falco, Cezary Cybulski et autres

pl, ca (code pays fourni par la source)

Survival from breast cancer in women with a BRCA2 mutation by treatment

D. Gareth Evans, Kelly‐Anne Phillips, Roger Laughlin Milne, Robert Fruscio et autres

BACKGROUND: The impact of various breast-cancer treatments on patients with a BRCA2 mutation has not been studied. We sought to estimate the impact of bilateral oophorectomy and other treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation. METHODS: We …

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Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

Aline Talhouk, Joshy George, Chen Wang, Timothy Budden et autres

Abstract Purpose: Gene expression–based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by nonstandardized methods, which are not applicable in a clinical …

ca, us, au, ua, gb, sg, de, pl, es, hu, fr (code pays fourni par la source)

Prognostic gene expression signature for high-grade serous ovarian cancer

Joshua Millstein, Timothy Budden, Ellen L. Goode, Michael S. Anglesio et autres

BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust …

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Serum selenium level and cancer risk: a nested case-control study

Steven Alexander Narod, Tomasz Huzarski, Anna Jakubowska, Jacek Gronwald et autres

Abstract Background Epidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low selenium levels. It is of interest to prospectively evaluate the relationship between selenium and cancer among women who reside in a region with ubiquitously …

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Blood arsenic levels and the risk of familial breast cancer in Poland

Wojciech Marciniak, Róża Derkacz, Magdalena Muszyńska, Piotr Baszuk et autres

Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research has focused on the effect of arsenic in populations with high endemic exposure, and not …

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A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

Nicola S. Meagher, Linyuan Wang, Peter Rambau, Maria P. Intermaggio et autres

au, ca, Tanzanie, us, gb, de, pl, se (code pays fourni par la source)

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes:an Ovarian Tumor Tissue Analysis consortium study

Peter Rambau, Robert Alan Vierkant, Maria P. Intermaggio, Linda E. Kelemen et autres

We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes.p16 protein expression was assessed by clinicalgrade immunohistochemistry in 6525 ovarian carcinomas including 4334 HGSC using tissue microarrays …

Tanzanie, ca, us, au, de, gb, es, br, pl (code pays fourni par la source)

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

Peter Rambau, Robert Alan Vierkant, Maria P. Intermaggio, Linda E. Kelemen et autres

We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ovarian carcinomas including 4334 HGSC using tissue …

ca, Tanzanie, us, au, de, gb, es, br, dk, pl, se (code pays fourni par la source)

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Matthew Stephen Block, Robert Alan Vierkant, Peter Rambau, Stacey J. Winham et autres

OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival …

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Meeting abstracts from the Annual Conference on Hereditary Cancers 2016

Cezary Cybulski, Wojciech Kluźniak, Tomasz Huzarski, Dominika Wokołorczyk et autres

2):A1We tested over 20, 000 genes by whole-exome sequencing in 144 Polish women with breast cancer from families with strong aggregation of this tumor.We identified a new breast cancer susceptibility gene (RECQL).In Poland, there is one major founder mutations of RECQL.Our results …

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