María Alonso de Leciñana

Rapid response vehicles vs mobile intensive care units in prehospital strokecode care: a retrospective cohort study

Andrea Higuera-Ruiz de la Hermosa, Nicolás Riera-López, Anitza Lorente-Moro, Elena de Celis et autres

Objetivos. Los vehículos de intervención rápida (VIR) son recursos de soporte vital avanzado similares a la unidad de vigilancia intensiva móvil (UVI-m), pero sin capacidad de transporte de pacientes, por lo que requiere el apoyo de una ambulancia de soporte vital básico …

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Revalidation of the M-DIRECT scale in prehospital identification of acute stroke patients for endovascular treatment

Jorge Rodríguez-Pardo, Nicolás Riera-López, Anitza Lorente-Moro, Elena de Celis et autres

The M-DIRECT scale was implemented for prehospital triage of acute stroke, such that patients with an M-DIRECT score ≥ 2 are transferred directly to an endovascular treatment (EVT)-ready center (EVT-C) instead of a nearer stroke unit (SU). Our aim is to evaluate …

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Efficiency of Neurologist-Led Focused Cardiac Ultrasound in the Acute Stroke Pathway (S-FoCUS)

Eduardo Mariño, Lara Pulido Fraiz, Carlos Hervás-Testal, Ricardo Rigual et autres

Background/Objectives: Although comprehensive transthoracic echocardiography (TTE) is part of the diagnostic workup in acute ischemic stroke, it is not cost-effective to use it for all patients. Guidelines recommend using it only for selected patients to guide secondary prevention. Neurologist-led, stroke-focused cardiac ultrasound …

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ABSTRACT NUMBER: ESOC2026A343 IMPACT OF NEUROLOGIST-LED FOCUSED CARDIAC ULTRASOUND IN THE ACUTE STROKE PATHWAY (S-FOCUS): EFFICIENCY AND DIAGNOSTIC VALUE

Eduardo Mariño, Lara Pulido-Fraiz, Carlos Hervás, Ricardo Rigual et autres

Abstract Background and aims Contemporary guidelines suggest cardiac echocardiogram for only in selected patients. We evaluated whether a neurologist-led stroke-focused cardiac ultrasound (S-FoCUS) improves diagnostic efficiency and reduces hospital length of stay without compromising diagnostic accuracy. Methods We conducted a retrospective before–after …

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ABSTRACT NUMBER: ESOC2026A758 TRENDS IN HOSPITAL DISCHARGES WITH A DIAGNOSIS OF PEDIATRIC STROKE IN SPAIN: A NATIONWIDE ANALYSIS

Eduardo Mariño, Carlos Hervás, Laura Vidal, Ricardo Rigual et autres

Abstract Background and aims Pediatric stroke leads to significant morbidity, yet nationwide longitudinal data regarding its epidemiology are scarce. We analyzed temporal trends in incidence, demographics, and in-hospital mortality rates in Spain. Methods A retrospective analysis (2005-2022) included Ischemic (IS) and Hemorrhagic …

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ABSTRACT NUMBER: ESOC2026A754 ADVANCED LEFT ATRIAL ECHOCARDIOGRAPHIC IN ATRIAL FIBRILLATION PRESENTING BREAKTHROUGH STROKE

Ricardo Rigual, Carlos Hervás, Sergio Castrejón‐Castrejón, Eduardo Mariño Trillo et autres

Abstract Background and aims Patients with atrial fibrillation (AF) who experience a breakthrough ischemic stroke despite anticoagulation represent a clinically complex population. Identifying predisposing atrial characteristics may refine risk stratification. We compared left atrial characteristics across AF clinical settings, including breakthrough stroke. …

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ABSTRACT NUMBER: ESOC2026A1349 EVALUATION OF EXECUTIVE FUNCTIONS IN STROKE PATIENTS WITH A NOVEL VIRTUAL REALITY TOOL

Laura Amaya-Pascasio, Rocío Rodríguez Herrera, Ana Sánchez Kuhn, Pilar Fernández Martín et autres

Abstract Background and aims Executive dysfunction is a frequent and disabling cognitive sequelae after stroke, particularly following damage to frontal and basal ganglia circuits. Conventional neuropsychological tests often lack ecological validity and may underestimate deficits affecting everyday functioning. Immersive virtual reality (VR) …

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ABSTRACT NUMBER: ESOC2026YS65 DUAL ULTRASOUND/PHOTOACOUSTIC IMAGING FOR EX VIVO CHARACTERIZATION OF CAROTID ATHEROSCLEROTIC PLAQUES: STUDY PROTOCOL AND PRELIMINARY FEASIBILITY

Eduardo Mariño, Bárbara Díaz, Maylin Perez-Liva, Paula Ibañez et autres

Abstract Background and aims The severity of carotid artery stenosis is currently the main criterion for indication of revascularization treatment for stroke prevention. However, stroke risk is influenced by plaque vulnerability—specifically the presence of a lipid-rich necrotic core, intra-plaque hemorrhage, and inflammation. …

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ABSTRACT NUMBER: ESOC2026A633 PROTEOMIC PROFILING OF CIRCULATING NERVOUS AND IMMUNE SYSTEMS-DERIVED EXTRACELLULAR VESICLES AS BIOMARKERS OF INTRACEREBRAL HAEMORRHAGE PATHOPHYSIOLOGY

Rebeca Gallego-Ruiz, Javier Pozo-Novoa, Fernando Laso, Ángela Calzado-González et autres

Abstract Background and aims Extracellular vesicles (EVs) are emerging as biomarkers reflecting dynamic biological responses after intracerebral haemorrhage (ICH). Building on our previous work showing that EVs are involved in tissue injury and repair, we aimed to characterize the temporal proteomic signatures …

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CogniPaz, an Ecologically Oriented Gamified mHealth Tool for Detecting Mild Cognitive Impairment: Prospective Diagnostic Accuracy Study (Preprint)

Carlos Estebas-Armas, Alejandro Medina-López, Daniel Blanco-de-Miguel, Itsaso Losantos-García et autres

Biomarkers for advancing diagnosis and prognosis in stroke

Steffen Tiedt, Alejandro Mejia Bustamante, Alan Cameron, Pol Camps-Renom et autres

The complexity and incomplete understanding of the pathophysiology of stroke poses substantial challenges to personalised medicine and the development of novel therapies, as reflected in the neutral results of many randomised trials. Current clinical algorithms lack the precision to diagnose stroke before …

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Stress-induced takotsubo syndrome: dynamic changes in regional cerebral metabolism revealed by quantitative PET imaging

Alejandro Ariza-Carrasco, Thulaciga Yoganathan, María Alonso de Leciñana, Thomas Viel et autres

Stress significantly contributes to cardiovascular diseases such as Takotsubo syndrome (TTS), which mimics an acute coronary syndrome without coronary obstruction. TTS is triggered by surgery, trauma, and emergency treatments in patients, and is reproduced in animal models by a catecholamine surge that …

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