Douglas M. Burns

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou et autres

Epilepsy is one of the most prevalent and serious brain disorders and affects over 70 million people globally. Antiseizure medications (ASMs) relieve symptoms and prevent the occurrence of future seizures in epileptic patients but have a limited effect on epileptogenesis. Addressing the …

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NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou et autres

Epilepsy is one of the most prevalent and serious brain disorders, affecting 70 million people worldwide. Antiseizure medications (ASMs) though relieve symptoms and prevent the occurrence of future seizures in epileptic patients have limited effect on epileptogenesis. Addressing the multifaceted nature of …

us (code pays fourni par la source)

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou et autres

Epilepsy is one of the most prevalent and serious brain disorders, affecting 70 million people worldwide. Antiseizure medications (ASMs) though relieve symptoms and prevent the occurrence of future seizures in epileptic patients have limited effect on epileptogenesis. Addressing the multifaceted nature of …

us (code pays fourni par la source)

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou et autres

Epilepsy is one of the most prevalent and serious brain disorders, affecting 70 million people worldwide. Antiseizure medications (ASMs) though relieve symptoms and prevent the occurrence of future seizures in epileptic patients have limited effect on epileptogenesis. Addressing the multifaceted nature of …

us (code pays fourni par la source)

Demographic Profile and Service-Connection Trends of Posttraumatic Stress Disorder and Traumatic Brain Injury in US Veterans Pre- and Post-9/11.

Hemant Kumar Thakur, Olurinde A. Oni, Vikas Singh, Rishi Sharma et autres

INTRODUCTION: This study seeks to understand the demographic changes in the active-duty service member profile, both prior to and following September 11, 2001 (9/11). The study analyzed diagnosis of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) and measures of severity …

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Increases in the Service Connection Disability and Treatment Costs Associated With Posttraumatic Stress Disorder and/or Traumatic Brain Injury in United States Veterans Pre- and Post-9/11: The Strong Need for a Novel Therapeutic Approach

Hemant Kumar Thakur, Olurinde A. Oni, Vikas Singh, Rishi Sharma et autres

Objective: To evaluate the relative distribution of service connection disability ratings among veterans with a diagnosis of Posttraumatic Stress Disorder (PTSD) and/or Traumatic Brain Injury (TBI) from all branches of service who went to war before and after a historic attack on …

Evaluating the Safety of Somatic Periosteal Cells by Flow-Cytometric Analysis Monitoring the History of DNA Damage

Tomoyuki Kawase, Kazuhide Hayama, Makoto Tsuchimochi, Masaki Nagata et autres

In preparing cell-based products for regenerative therapy, cell quality should be strictly controlled. Methodologies for evaluating cell viability, identity, and purity are established and used routinely, whereas current methodologies for evaluating cell safety, particularly genetic integrity or tumorigenicity, are time-consuming and relatively …

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X-ray and ultraviolet C irradiation–induced γ-H2AX and p53 formation in normal human periosteal cells in vitro: markers for quality control in cell therapy

Tomoyuki Kawase, Mana Kamiya, Kazuhide Hayama, Masaki Nagata et autres

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Real-time quantitative polymerase chain reaction and flow cytometric analyses of cell adhesion molecules expressed in human cell–multilayered periosteal sheets in vitro

Tomoyuki Kawase, Kohya Uematsu, Mana Kamiya, Masaki Nagata et autres

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Biological and biomechanical characterization of highly self-multilayered human periosteal sheets as an osteogenic grafting material

Tomoyuki Kawase, Kohya Uematsu, Masaki Nagata, Kensuke Okuda et autres

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Biomechanical evaluation by AFM of cultured human cell-multilayered periosteal sheets

Makoto Horimizu, Tomoyuki Kawase, Takaaki Tanaka, Kazuhiro Okuda et autres

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A Second-Generation 2-Methoxyestradiol Prodrug Is Effective against Barrett's Adenocarcinoma in a Mouse Xenograft Model

Suman Kambhampati, Roger A. Rajewski, Mehmet Tanol, Inamul Haque et autres

2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. In preclinical models, 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration, even after very high doses are administered to patients. In …

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