Nicolas Barbera

Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype

R. Noah Perry, Graham Lenert, Ernest Diez Benavente, Aydın Bölük et autres

BACKGROUND: Atherosclerosis, an inflammatory driver of coronary artery disease, manifests as unstable atheromatous plaques and stable fibrous plaques. Although atheromatous plaques have been extensively studied, fibrous plaques, particularly in women aged <50 years, where erosion contributes significantly to coronary thrombosis, remain less …

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Coronary artery disease-associated variants regulate vascular smooth muscle cell gene expression

Nicolas Barbera, Lily Lei, Alexia Wallace, Faruk Erin et autres

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An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease risk

Shuangyue Li, Xiaoning Song, Anastasiia Diagel, Ling Li et autres

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Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

R. Noah Perry, Graham Lenert, Ernest Diez Benavente, Angela Ma et autres

Abstract Atherosclerosis, a chronic inflammatory condition driving coronary artery disease (CAD), manifests in two primary plaque types: unstable atheromatous plaques and stable fibrous plaques. While significant research has focused on atheromatous plaques, recent studies emphasize the growing importance of fibrous plaques, particularly …

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Comprehensive identification of coronary artery disease-associated variants regulating vascular smooth muscle cell gene expression

Nicolas Barbera, Noah Perry, Lily Lei, Hester M. den Ruijter et autres

Abstract Coronary artery disease (CAD) is a complex disorder with genetic and environmental influences. Genome-wide association studies (GWAS) have identified over 300 genomic loci associated with disease risk. However, identifying the functional variants within these loci has been limited in large part …

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Abstract 3114: Time Course Multi-omics Approach Investigating Gene Expression Regulation During Vascular Smooth Muscle Cell Phenotypic Transitioning

Noah Perry, Warren D. Anderson, Nicolas Barbera, Mete Civelek

Coronary artery disease (CAD) is the leading cause of death in the United States. There is a need for novel therapeutic targets that prevent life-threatening consequences directly associated with plaque accumulation in the vascular wall—the underlying cause of CAD. During the progression …

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Dual pattern of cholesterol-induced decoupling of residue-residue interactions of Kir2.2

Katie Beverley, Nicolas Barbera, Irena Levitan

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Dual Pattern of Cholesterol-Induced Decoupling of Residue-Residue Interactions of Kir2.2

Katie Beverley, Nicolas Barbera, Irena Levitan

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Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

Nicolas Barbera, Sara T. Granados, Carlos G. Vanoye, Т. В. Абрамова et autres

Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular mechanisms through which cholesterol binding alters channel function are virtually unknown. In this study, we used a combination of Martini …

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Noncanonical function of long myosin light chain kinase in increasing ER‐PM junctions and augmentation of SOCE

Nityanand Srivastava, Mohammad Tauseef, Md Ruhul Amin, Bhagwati Joshi et autres

Abstract Increased endothelial permeability leads to excessive exudation of plasma proteins and leukocytes in the interstitium, which characterizes several vascular diseases including acute lung injury. The myosin light chain kinase long (MYLK‐L) isoform is canonically known to regulate the endothelial permeability by …

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Molecular Simulations of Kir-Cholesterol Interactions Uncover Cholesterol-Mediated De-Coupling of Functional Domains Important for Gating

Nicolas Barbera, Belinda S. Akpa, Irena Levitan

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Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Rita Gutorov, Maximilian Peters, Ben Katz, Tal Brandwine et autres

Many studies have shown the involvement of cholesterol in the modulation of ion channels function. The mechanisms suggested for these effects included a highly flexible binding site, adopting multiple poses in a “cloud”, rather than occupying a single conformation, or the perturbation …

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