Valentina Schüppel

Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome

Annick V. Hartstra, Valentina Schüppel, Sultan Imangaliyev, Anouk Schrantee et autres

OBJECTIVE: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. METHODS: I-FP-CIT-determined) brain …

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The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

Marta Olivares, Valentina Schüppel, Ahmed M. Hassan, Martín Beaumont et autres

The dipeptidyl-peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut …

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Dietary fat and gut microbiota interactions determine diet-induced obesity in mice

Raphaela Kübeck, Catalina Bonet-Ripoll, Christina Hoffmann, Alesia Walker et autres

Objective Gut microbiota may promote positive energy balance; however, germfree mice can be either resistant or susceptible to diet-induced obesity (DIO) depending on the type of dietary intervention. We here sought to identify the dietary constituents that determine the susceptibility to body …

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Microbiome and metabolic disorders related to obesity: Which lessons to learn from experimental models?

Audrey M. Neyrinck, Valentina Schüppel, Trevor Lockett, Dirk Haller et autres

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Das Mikrobiom bei chronischen Erkrankungen

Valentina Schüppel, Dirk Haller

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Maternal High-fat Diet Accelerates Development of Crohnʼs Disease-like Ileitis in TNFΔARE/WT Offspring

Lisa Gruber, Jana Hemmerling, Valentina Schüppel, Michael Müller et autres

BACKGROUND: Maternal high-fat diet (HFD) and obesity increases the risk of the offspring to develop inflammatory processes in various organs including the gut. We hypothesized that maternal diet-induced obesity programs the fetal gut towards inflammation in a mouse model of genetically-driven Crohn's …

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Diet‐induced obesity causes metabolic impairment independent of alterations in gut barrier integrity

Caroline Kleß, Veronika Maria Müller, Valentina Schüppel, Martina Lichtenegger et autres

SCOPE: The causal relationship between diet-induced obesity and metabolic disorders is not clear yet. One hypothesis is whether the obese state or high-fat diet per se affects intestinal barrier function provoking metabolic comorbidities. METHODS AND RESULTS: In three independent experiments with AKR/J, …

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New Insights into the Interplay Between the Lysine Transporter LysP and the pH Sensor CadC in Escherichia Coli

Martina Rauschmeier, Valentina Schüppel, Larissa Tetsch, Kirsten Jung

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