Catherine R. Dillon

Intravenous Argatroban or Eptifibatide in Patients Undergoing Mechanical Thrombectomy

Ian Rines, Opeolu M Adeoye, Andrew David Barreto, Joseph P. Broderick et autres

Importance: The addition of direct thrombin inhibitors or glycoprotein platelet inhibitors to intravenous thrombolysis in patients undergoing endovascular thrombectomy for acute ischemic stroke may improve reperfusion rates and clinical outcomes. Objective: To investigate the safety and efficacy of these agents. Design, Setting, …

us, ir (code pays fourni par la source)

Electroconvulsive therapy for the acute management of severe agitation in dementia (ECT-AD): A modified study protocol

Maria I. Lapid, Julia G. Merrill, Martina Mueller, Adriana Patricia Hermida et autres

OBJECTIVE: This study began as a single-blind randomized controlled trial (RCT) to investigate the efficacy and safety of electroconvulsive therapy (ECT) for severe treatment-refractory agitation in advanced dementia. The aims are to assess agitation reduction using the Cohen-Mansfield Agitation Inventory (CMAI), evaluate …

us (code pays fourni par la source)

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy

Hooman Kamel, Will T. Longstreth, David Tirschwell, Richard A. Kronmal et autres

Importance: Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It is unknown whether anticoagulation, which has proven benefit in atrial fibrillation, prevents stroke in patients with atrial cardiopathy and no atrial fibrillation. Objective: To compare anticoagulation …

us, ca (code pays fourni par la source)

EP02.46: An AI system (SonoLyst) achieves expert level performance when categorising images for adherence to ISUOG mid‐trimester screening guidelines

Aris T. Papageorghiou, S. R. Walton, Michael J. Benson, S. Meagher et autres

To evaluate the performance of SonoLyst (GEHC, Zipf), an Artificial Intelligence (AI) based algorithm, in undertaking “peer review” of images required for complete routine mid-trimester ultrasound scans according to ISUOG guidelines. Multicentre prospective evaluation using real-world images captured from 4 sites during …

gb, us (code pays fourni par la source)

Optimal Randomization Designs for Large Multicenter Clinical Trials: From the National Institutes of Health Stroke Trials Network Funded by National Institutes of Health/National Institute of Neurological Disorders and Stroke Experience

Wenle Zhao, Sharon D. Yeatts, Joseph P. Broderick, Magdy H. Selim et autres

From 2016 to 2021, the National Institutes of Health Stroke Trials Network funded by National Institutes of Health/National Institute of Neurological Disorders and Stroke initiated ten multicenter randomized controlled clinical trials. Optimal subject randomization designs are demanded with 4 critical properties: (1) …

us, in (code pays fourni par la source)

Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure

Babak John Orandi, Chandler McLeod, Paul A. MacLennan, William M. Lee et autres

Importance: In January 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by March 2014. Objective: To assess the odds of hospitalization and …

us, ca (code pays fourni par la source)

Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis

Ḱazunori Toyoda, Sohei Yoshimura, Mayumi Fukuda‐Doi, Adnan Iqbal Qureshi et autres

The effects of acute systolic blood pressure levels achieved with continuous intravenous administration of nicardipine for Japanese patients with acute intracerebral hemorrhage on clinical outcomes were determined. A systematic review and individual participant data analysis of articles were performed based on prospective …

jp, us, cn, tw (code pays fourni par la source)

Ten practical questions to improve data quality

Sarah E. McCord, Justin L. Welty, Jennifer L. Courtwright, Catherine R. Dillon et autres

High-quality rangeland data are critical to supporting adaptive management. However, concrete, cost-saving steps to ensure data quality are often poorly defined and understood. Data quality is more than data management. Ensuring data quality requires 1) clear communication among team members; 2) appropriate …

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A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure

Oliver D. Tavabie, Constantine Jason Karvellas, Jaime Lynn Speiser, Christopher F. Rose et autres

gb, ca, us (code pays fourni par la source)

Why Are Women Less Represented in Intracerebral Hemorrhage Trials?

Tatiana Greige, Casey Norton, Lydia D. Foster, Sharon D. Yeatts et autres

Background and Purpose: Fewer women than men tend to be enrolled in clinical trials of intracerebral hemorrhage. It is unclear whether this reflects lower prevalence of intracerebral hemorrhage in women, selection bias, or poor recruitment efforts. We undertook this study to examine …

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National Institutes of Health StrokeNet During the Time of COVID-19 and Beyond

Joseph P. Broderick, Jordan Elm, L. Scott Janis, Wenle Zhao et autres

us, au (code pays fourni par la source)

Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

James M. Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm et autres

us, gb (code pays fourni par la source)