Jacob Donoghue

Disruption of interareal control during propofol anesthesia

Adam J. Eisen, André M. Bastos, Jacob Donoghue, Scott L. Brincat et autres

Abstract Anesthetic-induced unconsciousness may arise partly from a change in how brain areas can manipulate each other’s activity. To quantify this change, we use control-theoretic tools that can precisely characterize how easily subsystems in complex networks can control each other. These tools …

us (code pays fourni par la source)

Multicenter evaluation of the Waveband system for automated sleep assessment in patients with insomnia symptoms

Silvia Frati Savietto, Antoine Guillot, Mason Harris, Jay S. Pathmanathan et autres

STUDY OBJECTIVES: This study (Octave-3) aimed to validate the performance of the Waveband dry-electroencephalography sensor device for automatic sleep staging and sleep parameter estimation as compared to gold-standard in-lab polysomnography (PSG). METHODS: Forty-five participants were enrolled, and 38 completed simultaneous PSG and …

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Similar destabilization of neural dynamics under different general anesthetics

Adam J. Eisen, Alexandra G Bardon, Jesus Javier Ballesteros, André M. Bastos et autres

Different classes of anesthetics induce unconsciousness despite acting through distinct molecular mechanisms, raising the possibility that their convergent effects arise at the level of the dynamics of neural population activity. To explore this, we analyze intracortical electrophysiological recordings during infusions of propofol, …

us, de (code pays fourni par la source)

Usability and stability of longitudinal at-home sleep evaluation using the Waveband electroencephalogram headband in an insomnia population

Silvia Frati Savietto, Antoine Guillot, Jay S. Pathmanathan, Mason Harris et autres

Abstract Study Objectives Sleep monitoring outside of clinics could enhance care for insomnia and other sleep disorders but requires home systems that are easily operable and provide consistent data quality over multiple nights. We assessed the Waveband for usability by participants and …

The Insomnia EEG Score: a new tool for the classification of people with poor sleep

Jay S. Pathmanathan, David Little, Kolia Sadeghi, Tobias Di Marco et autres

Quantitative features could help objectively identify and grade insomnia severity, though there is currently no pathophysiological biomarker of insomnia. In this study, we used the largest cohort of individuals with and without insomnia to date to train a model capable of distinguishing …

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State–Space Trajectories and Traveling Waves Following Distraction

Tamal Batabyal, Scott L. Brincat, Jacob Donoghue, Mikael Lundqvist et autres

Cortical activity shows the ability to recover from distractions. We analyzed neural activity from the pFC of monkeys performing working memory tasks with mid-memory delay distractions (a cued gaze shift or an irrelevant visual input). After distraction, there were state-space rotational dynamics …

us, se (code pays fourni par la source)

Similar destabilization of neural dynamics under different general anesthetics

Adam J. Eisen, Alexandra G Bardon, Jesus Javier Ballesteros, André M. Bastos et autres

Different classes of anesthetics can induce unconsciousness despite acting through distinct biological mechanisms. This raises the possibility that they produce a convergent effect on the dynamics or temporal evolution of neural population activity. To explore this, we analyzed intracortical electrophysiological recordings during …

us (code pays fourni par la source)

The role of sleep in Alzheimer’s disease: a mini review

Jay S. Pathmanathan, Michael Brandon Westover, Sudhir Sivakumaran, Jacob Donoghue et autres

Sleep is a stereotyped and well-preserved series of neurophysiological states that are essential for overall health and brain functioning. Emerging research suggests that sleep disturbances are not only associated with but also causally contribute to neurodegenerative disease onset and progression. This mini-review …

Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity

Yihan Xiong, Jacob Donoghue, Mikael Lundqvist, Meredith K. Mahnke et autres

Predictive coding is a fundamental function of the cortex. The predictive routing model proposes a neurophysiological implementation for predictive coding. Predictions are fed back from the deep-layer cortex via alpha/beta (8 to 30 Hz) oscillations. They inhibit the gamma (40 to 100 …

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Propofol anesthesia destabilizes neural dynamics across cortex

Adam J. Eisen, Leo Kozachkov, André M. Bastos, Jacob Donoghue et autres

Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability of the brain to balance excitability with the need to be stable and controllable. To test this hypothesis, we developed a method for …

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Hyperarousal features in the sleep architecture of individuals with and without insomnia

Tobias Di Marco, Thomas E. Scammell, Kolia Sadeghi, Alexandre Datta et autres

Sleep architecture encodes relevant information on the structure of sleep and has been used to assess hyperarousal in insomnia. This study investigated whether polysomnography-derived sleep architecture displays signs of hyperarousal in individuals with insomnia compared with individuals without insomnia. Data from Phase …

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Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder: a pooled post hoc analysis of two randomized phase 3 clinical studies

Tobias Di Marco, Ina E. Djonlagic, Yves A Dauvilliers, Kolia Sadeghi et autres

STUDY OBJECTIVES: Post hoc analysis to evaluate the effect of daridorexant on sleep architecture in people with insomnia, focusing on features associated with hyperarousal. METHODS: We studied sleep architecture in adults with chronic insomnia disorder from two randomized phase 3 clinical studies …

ch, us, fr, de, it (code pays fourni par la source)