Zheyao Wen

An atlas of cGAS-STING signaling in pathophysiological angiogenesis and retinal vascular homeostasis across species

Xuemin He, Rui Zeng, Siying Wen, Zheyao Wen et autres

. This study demonstrated an evolutionally conserved interaction between cGAS-STING signaling and VEGFA-VEGFR2 signaling in pathophysiological angiogenesis and vascular homeostasis, thus providing a novel therapeutic target for treating retinal vascular diseases.

cn (code pays fourni par la source)

Endothelia-targeting eye drops deliver a STING inhibitor to effectively reduce retinal neovascularization in ischemic retinopathy

Siying Wen, Xuemin He, Jiachen Wang, Zheyao Wen et autres

cn, cz, hk (code pays fourni par la source)

Corrigendum to “Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species” [Journal of Molecular and Cellular Cardiology 187(2024) 51–64]

Linli Wang, Min Wang, Haiming Niu, Yaping Zhi et autres

cn (code pays fourni par la source)

Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

Xuemin He, Siying Wen, Xixiang Tang, Zheyao Wen et autres

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) protect against diabetic cardiovascular diseases and nephropathy. However, their activity in diabetic retinopathy (DR) remains unclear. Our retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other …

cn (code pays fourni par la source)

Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species

Linli Wang, Min Wang, Haiming Niu, Yaping Zhi et autres

cn (code pays fourni par la source)

Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity

Nan Cai, Xuanrong Chen, Jia Liu, Zheyao Wen et autres

Type 2 diabetes mellitus remains a substantial medical problem with increasing global prevalence. Pharmacological research is becoming increasingly focused on personalized treatment strategies. Drug development based on glucokinase (GK) activation is an important strategy for lowering blood glucose. This study aimed to …

cn (code pays fourni par la source)

Hyperlipidemia induces proinflammatory responses by activating STING pathway through IRE1α-XBP1 in retinal endothelial cells

Zheyao Wen, Xuemin He, Jin Wang, Heting Wang et autres

cn (code pays fourni par la source)