Philamer Calses

Abstract 4506 A screening platform to target intrinsically disordered regions (IDRs) of chromatin factors in disease

Laura J Hsieh, Muryam A. Gourdet, Philamer Calses

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Abstract 5949: The clinical dual KRASG12C inhibitor FMC-376 has demonstrated potential as both a monotherapy and in combination for the treatment of patients with KRASG12C mutation positive NSCLC

Yan Wang, Allison W. Roberts, Philamer Calses, Richard M. Neve et autres

Abstract KRAS, a membrane-associated guanosine triphosphatase (GTPase), is the most frequently mutated oncogene in cancer with activating mutations occurring in approximately 25% of NSCLC. Of these, KRASG12C occurs in approximately 14% of adenocarcinomas and in 0.5 to 4% of squamous NSCLCs. This …

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Abstract 1142: Discovery of FMC-376 a novel orally bioavailable inhibitor of activated KRASG12C

Snahel Patel, Barun Bhhatarai, Philamer Calses, Daniel Erlanson et autres

Abstract KRAS is one of the most frequently mutated genes in cancer and was long considered undruggable until the recent discovery of inhibitors that bind the inactive (GDP-bound) form of KRASG12C. The most clinically advanced of these first-generation molecules have demonstrated clinical …

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Supplementary Methods, Figures 1 - 10, Tables 1 - 3 from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

PDF file - 2066K, S1. MiR-103 and miR-107 inhibit DNA damage-induced RAD51 foci formation in cancer cells. S2. MiR-103 and miR-107 promote chemosensitivity in U2OS cells. S3. MiR-103 and miR-107 promote chemosensitivity to cisplatin and a PARP inhibitor in HeLa and PEO1 …

Supplementary Table 4 from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

XLSX file - 86K, Summary of TCGA sample patient information used in correlation analyses.

Supplementary Methods, Figures 1 - 10, Tables 1 - 3 from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

PDF file - 2066K, S1. MiR-103 and miR-107 inhibit DNA damage-induced RAD51 foci formation in cancer cells. S2. MiR-103 and miR-107 promote chemosensitivity in U2OS cells. S3. MiR-103 and miR-107 promote chemosensitivity to cisplatin and a PARP inhibitor in HeLa and PEO1 …

Supplementary Table 4 from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

XLSX file - 86K, Summary of TCGA sample patient information used in correlation analyses.

Data from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

Abstract Homologous recombination mediates error-free repair of DNA double-strand breaks (DSB). RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors including RAD51, its paralogs, and breast/ovarian cancer susceptibility gene products BRCA1/2. Deregulation …

Data from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity

Jen‐Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses et autres

Abstract Homologous recombination mediates error-free repair of DNA double-strand breaks (DSB). RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors including RAD51, its paralogs, and breast/ovarian cancer susceptibility gene products BRCA1/2. Deregulation …

Supplementary Figures 1-11, Tables 1-2 from MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

Yemin Wang, Jen‐Wei Huang, Philamer Calses, Christopher J. Kemp et autres

PDF file - 1MB, Figure S1. Overexpression of miR-183-96-182 cluster miRNAs in U2OS cells. Figure S2. Effects of miR-183-96-182 cluster miRNAs on cisplatin-induced foci formation of RAD51, RPA2, FANCD2 and BRCA1. Figure S3. Overexpression of miR-96 sensitizes cancer cells to cisplatin and …

Supplementary Figures 1-11, Tables 1-2 from MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

Yemin Wang, Jen‐Wei Huang, Philamer Calses, Christopher J. Kemp et autres

PDF file - 1MB, Figure S1. Overexpression of miR-183-96-182 cluster miRNAs in U2OS cells. Figure S2. Effects of miR-183-96-182 cluster miRNAs on cisplatin-induced foci formation of RAD51, RPA2, FANCD2 and BRCA1. Figure S3. Overexpression of miR-96 sensitizes cancer cells to cisplatin and …

Data from MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

Yemin Wang, Jen‐Wei Huang, Philamer Calses, Christopher J. Kemp et autres

Abstract Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability. The DNA repair protein RAD51 and the trans-lesion synthesis DNA polymerase REV1 are required for resistance to DNA interstrand cross-linking agents such as cisplatin. In …