Sarama Saha

Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study

Jiya Singh, Sabyasachi Bandyopadhyay, Anindya Das, Anissa A. Mirza et autres

ABSTRACT Background: Depression is a major cause of reduced productivity and increased morbidity. Aim: Given its complex and multifactorial pathophysiology, this study investigated serum proteomic profiles in individuals with depression and healthy controls to identify differentially expressed proteins and their functional significance. …

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Association between heavy metal exposure and epigenetic modifications in patients with urinary bladder cancer

Ganesh Kumar Verma, Deepika Saini, Pankaj Kumar Chaudhary, Sarama Saha et autres

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Untargeted LC-MS/MS profiling identifies ST18 as a novel serum marker for T2DM-associated depression

Jiya Singh, Sabyasachi Bandyopadhyay, Atanu Sen, Ravi Kant et autres

Depression is a prevalent but underdiagnosed comorbidity in type 2 diabetes mellitus (T2DM), intensifying disease burden and complicating metabolic management. Reliable biomarkers for early detection remain limited. This study aimed to identify serum protein signatures associated with depression in individuals with T2DM …

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Abstract 2086 ASSOCIATION OF GSK 3 BETA GENE POLYMORPHISM WITH THE RISK OF DEVELOPMENT OF BIPOLAR DISORDER

Rashmi Nain, Sarama Saha, Nikhil Tak

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Association of Low-Density Lipoprotein Receptor-Related Protein 5 Haplotypes with Depression Risk in Type 2 Diabetes Mellitus: A Linkage Disequilibrium Approach

Jiya Singh, Praveen Kumar Singh, Rahul Amoli, Anindya Das et autres

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Retraction Note: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial

Prateek Kumar Panda, Indar Kumar Sharawat, Sarama Saha, Diksha Gupta et autres

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Correlation of heavy metal-induced epigenetic alterations in patients with urinary bladder cancer

Ganesh Kumar Verma, Deepika Saini, Pankaj Kumar Chaudhary, Sarama Saha et autres

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Correlation of Substance P Level in Blood and Cerebrospinal Fluid in Patients with Chronic Pain Syndromes: A Cross-sectional Study

Manasa Kantha, Pradeep Atter, Ajit Kumar, Baibhav Bhandari et autres

Background: Substance P (SP), a neuropeptide identified in 1931, is ubiquitously present in both the central (CNS) and peripheral (PNS) nervous systems, playing a pivotal role in nociceptive signal transmission and immune system responses. Aims and Objectives: This research aims to explore …

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Cancer-Induced Cardiac Dysfunction: Mechanisms, Diagnostics, and Emerging Therapeutics in the Era of Onco-Cardiology

Sarama Saha, Praveen Kumar Singh, Partha Roy, Vasa Vemuri et autres

Cancer-induced cardiac dysfunction has become a major clinical challenge as advances in cancer therapies continue to extend patient survival. Once regarded as a secondary concern, cardiotoxicity is now recognized as a leading contributor to morbidity and mortality among cancer patients and survivors. …

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Efficacy and safety of risperidone and aripiprazole in reducing severity of irritability in children with autism spectrum disorder: A randomized controlled trial

Prateek Kumar Panda, Indar Kumar Sharawat, Diksha Gupta, Achanya Palayullakandi et autres

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An insight into the association of sclerostin and disease activity in rheumatoid arthritis: A cross-sectional study

Tanu Varshney, Praveen Kumar Singh, Sarama Saha, Venkatesh S Pai

Objectives: Rheumatoid arthritis (RA) causes joint swelling and deformities, impacting quality of life. Wnt pathway dysregulation is linked to RA. Sclerostin (SOST), released from osteocytes, inhibits bone formation by interfering with Wnt signalling pathway and Dickkopf-1 (DKK-1) is a secreted protein which …

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Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line

Deepika Saini, Pankaj Kumar Chaudhary, Ganesh Kumar Verma, Jitendra Kumar Chaudhary et autres

Heavy metals are pervasive environmental and occupational carcinogens known to induce uncontrolled cell proliferation. They influence a number of cellular processes, including proliferation, metabolism, apoptosis, and carcinogenesis. Among the several underlying mechanisms of carcinogenesis, metal-induced aberrant modulation of DNA methyltransferase (DNMT) activity …

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