Clément Danthu

Real-World Evaluation of Letermovir Use in Kidney Transplant Recipients: Drug Interactions, Safety, and Impact on Renal Function

Iliès Benotmane, Betoul Schvartz, Cyril Garrouste, Florence Runyo et autres

Letermovir is approved for primary prophylaxis of cytomegalovirus (CMV) infection in seropositive donor/seronegative kidney transplant recipients (KTRs). 1,2 Letermovir inhibits CYP3A4, raising the risk of interactions with calcineurin inhibitors (CNIs) and mTOR inhibitors (mTORi). 3 Real-world data regarding these interactions are limited. …

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Determinants of virological outcomes in kidney transplant recipients treated with maribavir for refractory cytomegalovirus infection

Nathan Kasriel, Sophie Alain, Iliès Benotmane, N. Kamar et autres

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Posttransplantation diabetes mellitus (PTDM): pharmacological aspects and genetic predispositions

Dorian Chastagner, Hélène Arnion, Clément Danthu, Fatouma Touré et autres

Posttransplantation diabetes mellitus (PTDM) is a form of diabetes developed after solid organ or stem cell transplantation. This condition shares physiopathological traits with type 2 diabetes, including insulin resistance and β-cells dysfunction and its prevalence varies significantly based on the diagnostic criteria …

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Daptomycin Dosage Optimization in Renal Impairment Using Model-Informed Precision Dosing

Hamza Sayadi, Yeleen Fromage, Marc Labriffe, Clément Danthu et autres

BACKGROUND: Daptomycin's efficacy and toxicity are closely related to its exposure, which can vary widely among individuals. The patient, a 59-year-old male with an estimated glomerular filtration rate (eGFR) of 12 mL/min/1.73 m² and a weight of 64 kg, was treated with …

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Prophylactic treatment of FSGS recurrence in patients who relapsed on a previous kidney graft

Charlotte Uro-Coste, Céline Lambert, Vincent Audard, Lionel Couzi et autres

BACKGROUND: Recurrence of focal segmental glomerulosclerosis (FSGS) is common after kidney transplantation and is classically associated with a significant decrease in graft survival. A major risk factor is a prior history of FSGS recurrence on a previous graft. This analysis reports the …

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Toward an optimization of empirical antibiotic therapy in acute graft pyelonephritis: A retrospective multicenter study

P. Martinet, Luca Lanfranco, Anne Coste, Didier Tandé et autres

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Efficacy of rituximab in thymoma associated minimal change disease: case report

Zhour El Ouafi, Clovis Mugnier, Robin Jeannet, Clément Danthu et autres

BACKGROUND: Thymomas have been associated with a broad spectrum of autoimmune diseases. Minimal change disease (MCD) is the most frequent pathological lesion reported. Pathophysiological mechanisms involved in secondary MCD, and linking MCD to thymoma are not yet fully explained, although the hypothesis …

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Cinétique de la réponse humorale après administration d’un vaccin SARS-COV-2 mRNA dans une cohorte de patients transplantés et greffés rénaux

Fatouma Touré, Clément Danthu, Sébastien Hantz, Marion Duval et autres

Introduction Kidney transplant recipients and patients on hemodialysis are immunocompromised populations, prioritized for COVID 19 vaccination, but excluded from vaccine trials. Data are lacking regarding humoral response to COVID vaccination in immunocompromised patients. Description We investigated early serological response after COVID 19 …

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High Mortality and Graft Loss after Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study from Two Centers

Yanis Tamzali, Clément Danthu, Alexandra Aubry, Romain Brousse et autres

Kidney transplant recipients (KTRs) tend to develop infections with characteristic epidemiology, presentation, and outcome. While infective endocarditis (IE) is among such complications in KTRs, the literature is scarce. We describe the presentation, epidemiology, and factors associated with IE in KTRs. We performed …

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High Mortality and Graft Loss After Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study From Two Centers

Yanis Tamzali, Clément Danthu, Alexandra Aubry, Jean‐François Faucher et autres

Purpose: Kidney Transplant Recipients (KTRs) tend to develop infections with characteristic epidemiology, presentation and outcome. While infective endocarditis (IE) is among such complications in KTRs, literature is scarce. We describe the presentation, epidemiology, and factors associated with IE in KTRs. Methods: We …

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Humoral Response after SARS-CoV-2 mRNA Vaccination in a Cohort of Hemodialysis Patients and Kidney Transplant Recipients

Clément Danthu, Sébastien Hantz, Arthur Dahlem, Marion Duval et autres

BACKGROUND: Kidney transplant recipients and patients receiving hemodialysis are immunocompromised populations that are prioritized for COVID-19 vaccination but were excluded from clinical trials of SARS-CoV-2 mRNA vaccines. Antibody titers and rates of seroconversion after vaccination are lower among patients with CKD and …

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Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Vincent Dubée, Pierre‐Marie Roy, Bruno Vielle, Elsa Parot‐Schinkel et autres

OBJECTIVES: To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild to moderate coronavirus disease 2019 (COVID-19) at high risk of worsening. METHODS: We conducted a multicentre randomized double-blind placebo-controlled trial evaluating hydroxychloroquine in COVID-19 patients with at …

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