Anna Rýdlová

Recent developments in typhoidal and non-typhoidal Salmonella vaccines

Michael Blank, Anna Rýdlová, Malick M. Gibani

PURPOSE OF REVIEW: Typhoidal and invasive non-typhoidal Salmonella (iNTS) serovars remain leading causes of bloodstream infection, mortality and morbidity, particularly in South Asia and sub-Saharan Africa. The rising burden of antimicrobial resistance has strengthened the case for vaccination as a control strategy. …

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Safety and pathovariant-independent susceptibility in a Salmonella Typhimurium controlled human infection model: a phase 1, randomised, double-blind, dose-escalation study

C. Smith, Anna Rýdlová, Robert Varro, Emma Smith et autres

ABSTRACT Background Invasive non-typhoidal Salmonella (iNTS) disease causes an estimated 605,000 cases and 76,000 deaths each year, concentrated in sub-Saharan Africa, where the African Salmonella Typhimurium sequence type 313 (ST313) lineage predominates. Vaccine development is hampered by an absence of efficacy data …

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Recent developments in typhoidal and non-typhoidal salmonella vaccines

Michael B. Blank, Anna Rýdlová, Malick M. Gibani

Development of a live-attenuated vaccine challenge model of Yersinia pestis in humans: Expert consultation on clinical trial considerations, January 2025

Anna Rýdlová, Emma Smith, Arabella Stuart, Robin J. Shattock et autres

Yersinia pestis is the causative agent of plague - the archetypal bacterial pandemic disease. Plague remains endemic in several countries in Africa, South America, and Asia, posing high risks of zoonotic spill-over and epidemic spread or threat of deliberate release. Plague vaccine …

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Comparative phenotypic, genomic and transcriptomic characterisation of two Salmonella Typhimurium strains for a first-in-human challenge model

Christopher Smith, Anan Bzami, Xiaojun Zhu, Jessica A. White et autres

Abstract Background Invasive non-typhoidal Salmonella (iNTS) disease remains a major public health challenge in sub-Saharan Africa. Salmonella Typhimurium is responsible for the majority of cases, with specific lineages being associated with increased risk of bloodstream infection. We have recently developed a Salmonella …

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Education of pupils with diagnosed anxiety disorder in elementary school

Anna Rýdlová

The thesis addresses the issue of supporting students with Generalized Anxiety Disorder (GAD) in the primary school environment. The aim of the thesis is to analyze appropriate pedagogical approaches, strategies for working with the classroom collective, and the importance of collaboration between …

Optical projection tomography implemented for accessibility and low cost ( OPTImAL )

Chad E. Darling, Sunil Kumar, Y.I. Alexandrov, J. de Faye et autres

Optical projection tomography (OPT) is a three-dimensional mesoscopic imaging modality that can use absorption or fluorescence contrast, and is widely applied to fixed and live samples in the mm-cm scale. For fluorescence OPT, we present OPT implemented for accessibility and low cost, …

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In vitro activity of antibiotics potentially effective against difficult-to-treat strains of Gram-negative rods: retrospective study

Gabriela Kroneislová, Jan Závora, Vanda Gabriela Adámková, Anna Rýdlová et autres

Bacterial resistance surveillance is one of the main outputs of microbiological laboratories and its results are important part of antimicrobial stewardship (AMS). In this study, the susceptibility of specific bacteria to selected antimicrobial agents was tested. The susceptibility of 90 unique isolates …

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Protocol for the challenge non-typhoidalSalmonella(CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection model in the UK

Christopher Smith, Emma Smith, Anna Rýdlová, Robert Varro et autres

Introduction Invasive non-typhoidalSalmonella(iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting,Salmonella entericaserovar Typhimurium accounts for two-thirds of infections and is associated with an estimated case fatality rate of 15%–20%. Several iNTS vaccine candidates are …

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Ikebana a její vliv na evropskou tvorbu

Anna Rýdlová

This bachelor's thesis on Ikebana and its influence on European floral design looks at the Japanese style of flower arranging and its influence on floral design in other countries outside of Japan. Ikebana is a style of floral arrangement characterised by simple …

Investigating fibins in zebrafish development and regeneration

Anna Rýdlová

Zebrafish, Danio rerio, is a widely accepted model of tissue regeneration. Yet, thorough understanding of the cellular and molecular pathways that govern the tightly regulated responses to injury still remain to be fully understood. Characterization of these molecular events holds a great …

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Dynamics of repair and regeneration of adult zebrafish respiratory gill tissue after cryoinjury

Marie‐Christine Ramel, Fränze Progatzky, Anna Rýdlová, Madina Wane et autres

Abstract The study of respiratory tissue damage and repair is critical to understand not only the consequences of respiratory tissue exposure to infectious agents, irritants and toxic chemicals, but also to comprehend the pathogenesis of chronic inflammatory lung diseases. To gain further …

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