Accès ouvert
2026
preprint
OpenAlex
Sagiv Cohen, Benjamin Trabelcy, Doron Shalom Yishai Zaada, Philippos Aris Papathanos et autres
Abstract Mosquitoes undergo major metabolic remodeling as they transition from aquatic larvae to terrestrial, blood-feeding adults, yet the biochemical principles supporting these life cycle transitions remain poorly understood 1 . Early metabolic studies established that mosquitoes are sterol auxotrophs 2,3 ; however, …
il
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Rocco D'Amato, Elad Shmuel Yonah, Alessia Cagnetti, Flávia Krsticevic et autres
Abstract Y chromosome sex distorters offer a powerful strategy for mosquito population suppression, but their implementation is constrained by the transcriptional silencing of Y-linked transgenes during spermatogenesis. To investigate how endogenous Y genes evade this repression, we characterized draupnir (formerly YG5 ), …
it, il, gb
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Lee Benjamin Lamdan, Sigal Popovsky-Sarid, Ebrima SM Kolley, Arad Sarig et autres
Abstract Sex-ratio distortion systems are promising genetic tools for mosquito population control. Two strategies have been proposed: prezygotic elimination of X-bearing sperm by X-shredding, which can drive invasive Y-chromosome transmission when sex distorters are Y-linked, and postzygotic daughter killing through disruption of …
il, us, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Arad Sarig, Evyatar Sar-Shalom, Ebrima S M Kolley, Elad Shmuel Yonah et autres
Anopheles gambiae is one of the principal vectors of human malaria. Over the past 2 decades, transgenic mosquito strains have been essential tools for studying mosquito biology and developing genetic control strategies such as gene drives. Mosquito transformants are typically identified using …
il
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Doron Shalom Yishai Zaada, Or Toren, Flávia Krsticevic, Daniella An Haber et autres
Effective sex separation remains a critical challenge for mosquito genetic control. Genetic sexing strains (GSS) address this by linking maleness with selectable traits, enabling efficient female removal. Here, we present a versatile platform for GSS development in the invasive Aedes albopictus mosquito …
il, de, fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Evyatar Sar-Shalom, Ziv Kassner, Arad Sarig, Clément Vinauger et autres
Abstract Understanding mosquito behavior is key to advancing research in ecology, evolution, and disease control, yet most behavioral assays rely on human-dependent methods, such as real-time observation or manual frame-by-frame annotation, limiting throughput and reproducibility. We present YOLito, a domain-generalized AI model …
il, al, us, se
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Dimitris Rallis, Konstantina T. Tsoumani, Flávia Krsticevic, Philippos Aris Papathanos et autres
The detection and characterization of sex chromosome sequences is particularly important for major pest families, like the Tephritidae, whereas alternative pest management approaches, mainly involving male-only release programs, rely on the ability to target and manipulate sex-specific genomic regions, particularly those of …
gr, il, gb, au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Giovanni Petrucci, Maria‐Eleni Gregoriou, Philippos Aris Papathanos, Marc F. Schetelig et autres
The sterile insect technique, which consists of the mass production and release of sterile insects to control populations of pests and disease vectors, has been effectively used for decades. An important component of sterile insect technique field applications is the availability of …
at, de, il, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Gleb Ens, A. Lewin, Doron Shalom Yishai Zaada, Ziv Gilan et autres
Abstract Female mosquitoes must feed on blood to produce eggs, a natural behavior that also drives disease transmission. Vector biology research and the development of novel control tools depend on reliable methods for blood feeding of laboratory-reared mosquitoes. Artificial membrane feeders have …
il
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yael Arien, Chen Zacharia, Elad Shmuel Yonah, Elad Bonda et autres
Abstract CRISPR-Cas9 sex ratio distortion (SRD) systems can suppress insect populations by biasing progeny toward males, but realizing such systems requires reliable Cas9 expression from insect Y chromosomes. Here, we tested whether the spermatocyte-specific β Tub85D promoter can drive functional Cas9 expression …
il
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Arad Sarig, Evyatar Sar-Shalom, Ebrima SM Kolley, Elad Shmuel Yonah et autres
Abstract Anopheles gambiae is one of the principal vectors of human malaria. Over the past two decades, transgenic mosquito strains have been essential tools for studying mosquito biology and developing genetic control strategies such as gene drives. Mosquito transformants are typically identified …
il
(code pays fourni par la source)
Accès ouvert
2025
review
OpenAlex
Doron Shalom Yishai Zaada, Philippos Aris Papathanos, Éric Marois
Among other challenges, the world currently faces the expansion of pest insects such as the tiger mosquito Aedes albopictus , a growing threat to public health due to the pathogens it can transmit. Current control approaches based on insecticides or elimination of …
il, fr
(code pays fourni par la source)