Sherif Hanafy Mahmoud

The Development and Validation of a Simple Method for the Determination of Meropenem Concentrations in Human Plasma Using High‐Performance Liquid Chromatography

Asma Aboelezz, Maged Kharouba, Sherif Hanafy Mahmoud

ABSTRACT Meropenem is a beta‐lactam antimicrobial that is used to treat severe infections. Critically ill patients are highly prone to pharmacokinetics variability and a fluctuation in meropenem plasma concentrations. The aim of this study is to provide a simple, rapid, precise and …

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Protocol‐Based Management of Medication Confounders in Brain Death Determination: A Multi‐Institutional Review

Alexander R. Nixon, Jeffrey Mucksavage, Chris Morrison, Nicholas Panos et autres

BACKGROUND: Determination of death by neurologic criteria (DNC) relies on clinical examination, provided no confounding conditions affect reliability. Current guidelines require patients to be free of confounders before neurologic testing but do not specify how these confounders should be assessed or managed. …

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Treatment of Antithrombotic-Associated Intracranial Hemorrhage in Adults: A Focused Guideline Update from the Neurocritical Care Society and the Society of Critical Care Medicine

Meghan Caylor Vallejo, Lori Kennedy, Bradley A. Dengler, Colleen Barthol et autres

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Development and Validation of an HPLC–UV Method for the Quantification of Cefepime in Human Plasma for Routine Clinical Monitoring

Maged Kharouba, Asma Aboelezz, Adham Elshamy, Aaron Cook et autres

ABSTRACT Cefepime, a broad‐spectrum fourth‐generation cephalosporin, is widely used to treat nosocomial infections. Dependence upon renal elimination makes its pharmacokinetics highly susceptible to changes in renal function, which are common in critically ill patients. Both acute kidney injury and augmented renal clearance …

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The Role of Metabolites in Acyclovir-Induced Neurotoxicity and Nephrotoxicity

Asma Aboelezz, Sherif Hanafy Mahmoud

Acyclovir is an antiviral drug effective against infections caused by herpes simplex and varicella zoster viruses. It is given intravenously to treat serious infections such as herpes encephalitis. High acyclovir concentrations could cause toxicity, observed mainly as nephrotoxicity and, to a lesser …

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Implementation of pharmacogenomics within community pharmacies in Alberta, Canada: An observational study

Dalia Amr Hamdy, Sherif Hanafy Mahmoud, Dareen Elsayed, Meagan Shields et autres

Levetiracetam Dosing Optimization in Neurocritical Care Population: Neuro-ARC Study

Maged Kharouba, Aaron M. Cook, Melissa L. Thompson Bastin, Demetrios J. Kutsogiannis et autres

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Pharmacotherapy variability and precision medicine in neurocritical care

Sherif Hanafy Mahmoud, Maged Kharouba, Asma Aboelezz, Adham Elshamy

Pharmacotherapy variability is defined as the variability in drug response among and within individuals that is attributed to the inter and intra-individual differences in the action and disposition of drugs. Neurological and medical complications in neurocritical care contribute significantly to the overall …

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Extended stability of bivalirudin in intravenous solutions

Sherif Hanafy Mahmoud, Forugh Sanaee, Lindsay M. Ryerson, Mary Bauman et autres

Abstract Background Bivalirudin is the preferred anticoagulant for pediatric ventricular assist device (VAD) patients. The manufacturer only permits the diluted drug to be used for 24 h once mixed with the sterile solutions. Most infants on VAD require much less than a …

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Acyclovir dosing strategies in herpes encephalitis: A retrospective charts review

Asma Aboelezz, Maged Kharouba, Sherif Hanafy Mahmoud

BACKGROUND: Herpes encephalitis is a life-threatening condition that causes severe inflammation of the brain, often leading to permanent neurological damage or death if not treated promptly. Acyclovir is the main antiviral treatment for herpes encephalitis. Early use is essential to lower the …

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The Evolution of Neurocritical Care Pharmacy: Historical Perspectives and Future Horizons

Denise H. Rhoney, Aaron M. Cook, Karen Berger, Sherif Hanafy Mahmoud et autres

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Exploring the Impact of Medication Confounders on Determining Death by Neurologic Criteria: An International Survey Investigating Practice Variations

Casey C. May, Jeffrey Mucksavage, Christopher N. Morrison, Nicholas Panos et autres

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