Giuliana Ceriani

Prescription of SGLT-2 inhibitors alone or in combination with RAS-inhibitors in patients with diabetes mellitus and comorbid cardiovascular disease, chronic kidney disease or cardiorenal disease: a real-world evidence study from the REPOSI registry

Paolo Lido, Sara Ratti, Chiara Ronchetti, Marco Infante et autres

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Clinically recognized sepsis in older adults admitted to medical wards: patient characteristics and hospital outcomes from the REPOSI register

Marta Chiara Sircana, Alfredo Caturano, Mauro Tettamanti, Sara Ratti et autres

Older adults admitted to internal medicine wards represent a growing population at high risk of sepsis, characterized by frailty, multimorbidity, functional impairment and reduced physiological reserve. While sepsis outcomes have been extensively studied in intensive care settings, less is known about prognostic …

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Prescribing cascades among hospitalized older adults: a retrospective cohort study from the REPOSI registry

Alice Restelli, Chiara Crippa, Alessandro Nobili, Pier Mannuccio Mannucci et autres

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Unnecessary use of proton pump inhibitors in patients discharged on oral anticoagulant therapy: data from the REPOSI registry

Chiara Elli, Alessio Novella, Luca Pasina, Pier Mannuccio Mannucci et autres

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Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study

Carlotta Franchi, Sara Mandelli, Ilaria Ardoino, Alessandro Nobili et autres

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Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Elena Succurro, Alessio Novella, Alessandro Nobili, Federica Giofrè et autres

Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register. Succurro E, Novella A, Nobili A, Giofrè F, Arturi F, Sciacqua A, Andreozzi F, Pietrangelo A, Sesti G; REPOSI Investigators. Intern Emerg …

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Anemia management and transfusion strategy in internal medicine units: Less is more

Deborah Blanca, Giorgio Parrella, Dario Consonni, Stefania Villa et autres

Blood transfusion is one of the most overused procedures, especially in elderly patients. Despite the current transfusion guidelines recommending a restrictive transfusion strategy in stable patients, the clinical practice varies according to physicians' experience and implementation of patient blood management. This study …

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Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Elena Succurro, Alessio Novella, Alessandro Nobili, Federica Giofrè et autres

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing …

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Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Ernesto Crisafulli, Giulia Sartori, Alice Vianello, Fabiana Busti et autres

BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing …

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Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoSI Registry

Salvatore Corrao, Alessandro Nobili, Giuseppe Natoli, Pier Mannuccio Mannucci et autres

AIMS: The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged ≥ 65 years. …

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Modulation of Inflammatory Effects of Cytokines by the Neuropeptide α-MSH

J. M. Lipton, Nilum Rajora, Robert A. Star, S. Taherzadeh et autres

Inflammation is perhaps the most primitive of the host responses to challenge, and it is believed to promote survival. The inflammatory reaction involves multiple host cells, especially neutrophils and macrophages, and an ever-growing list of proinflammatory agents including certain cytokines. Cytokines are …

Pain and Frailty in Hospitalized Older Adults

Ilaria Ardoino, Carlotta Franchi, Alessandro Nobili, Pier Mannuccio Mannucci et autres

INTRODUCTION: Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. METHODS: In light of this …

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