Robert A. Star

Allograft and recipient tissue injury during cardiac allograft rejection: Evidence from cell-free DNA

T. Andargie, Naoko Tsuji, Naoki Hayase, Moon Kyoo Jang et autres

Cardiac allograft rejection (AR) is conventionally managed as an allograft disease. However, data from kidney transplant and proinflammatory cytokine studies suggest the occurrence of recipient tissue injury during AR, which remains poorly defined to date and is a recognized risk factor for …

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Different functions of human scavenger receptors BI and BII overexpressed in a murine abdominal sepsis model

Naoki Hayase, Tatyana G. Vishnyakova, Irina N. Baranova, Alexander V. Bocharov et autres

Class B scavenger receptors BI (SR-BI) and BII (SR-BII) internalize lipoproteins but also bind and internalize bacteria. Their roles in sepsis are unknown. We overexpressed human SR-BI and BII in the liver and kidney as well as bone marrow-derived macrophages, and then …

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Peritoneal neutrophil extracellular traps contribute to septic AKI via peritoneal IL-17A and distant organ CXCL-1/ CXCL-2 pathway in abdominal sepsis

Yoshitaka Naito, Daiki Goto, Naoki Hayase, Xuzhen Hu et autres

There are no specific treatments for Sepsis-associated acute kidney injury (AKI). We previously reported that Il-17a-knockout mice had dramatically improved survival after cecal ligation and puncture (CLP). Neutrophil extracellular traps (NETs) induce IL-17A, which causes harm in some diseases, but this pathway …

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Innovative Translational Models to Investigate AKI in the Context of Diabetes and Sepsis

Andrea Navarro, Ashley Bolds, Nicole Rainford, Xuzhen Hu et autres

Background: Acute kidney injury (AKI) in the setting of diabetes and sepsis remains a critical clinical issue, driven by the multifaceted interaction between metabolic and inflammatory stressors. To bridge the translational gap between bench and bedside, we established two complementary models designed …

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Genetic Deletion and Pharmacological Inhibition of CD36 Ameliorate Vancomycin-Induced AKI

Daiki Goto, Ashley Bolds, Xuzhen Hu, Alan T. Remaley et autres

Background: Vancomycin (VAN) is a widely used glycopeptide antibiotic active against Gram-positive cocci including methicillin-resistant Staphylococcus aureus (MRSA). VAN causes a high incidence of acute kidney injury (AKI), associated with a significantly increased mortality. CD36, also known as scavenger receptor class B …

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Human Scavenger Receptors BI and BII Overexpressed in Murine Abdominal Sepsis Model

Naoki Hayase, Tatyana G. Vishnyakova, Alexander V. Bocharov, Xuzhen Hu et autres

Background: Class B scavenger receptors BI (SR-BI) and BII (SR-BII) can bind and internalize lipoproteins and bacteria (our recent work in vitro). However, their roles in vivo in a clinically relevant sepsis model are unknown. Methods: We overexpressed human SR-BI and BII …

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Peritoneal Neutrophil Extracellular Traps contribute to septic AKI via peritoneal IL-17A and distant organ CXCL-1/ CXCL-2 pathway in abdominal sepsis.

Yoshitaka Naito, Daiki Goto, Naoki Hayase, Xuzhen Hu et autres

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Continuous Antithrombin III Infusion in a Clinically Relevant Sepsis Model

Naoki Hayase, Rohit R. Chari, Alef Aragao Carneiro dos Santos, Yoshitaka Naito et autres

BACKGROUND: Bolus antithrombin III (AT) improved sepsis/organ dysfunction and survival in lipopolysaccharide/monomicrobial infusion pretreatment animal models; however, AT failed in clinical trials. Because insults and drug administration schedules differed between preclinical and clinical settings, we re-examined AT using a clinically relevant polymicrobial …

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Translational Models for Diabetes and Sepsis-Induced Acute Kidney Injury

Andrea Navarro, Ashley Bolds, Nicole Rainford, Xuzhen Hu et autres

WITHDRAWN

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Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula

Yong He, Guo Wei, Tom Greene, Peter B. Imrey et autres

Abstract The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective cohort study. Participants underwent duplex ultrasound at postoperative Day …

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Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns

Irina N. Baranova, Alexander V. Bocharov, Tatyana G. Vishnyakova, Zhigang Chen et autres

The class B scavenger receptor CD36 is known to bind and mediate the transport of lipid-related ligands and it functions as a pattern recognition receptor (PRR) for a variety of pathogens, including bacteria and viruses. In this study, we assessed CD36's role …

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Continuous Antithrombin III Infusion in a Clinically Relevant Sepsis Model

Naoki Hayase, Rohit R. Chari, Yoshitaka Naito, Alef Aragao Carneiro dos Santos et autres

Background: Despite unacceptably high mortality and economic burden, effective therapeutic strategies for sepsis remain elusive. Discrepancies between drug responses in septic patients and animal models may be caused by differences in drug pharmacokinetics and timing of drug administration. Antithrombin III (AT) is …

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