Loredano Pollegioni

Valorization of Textile Waste: Enzymatic Upcycling of Terephthalic Acid Toward a Sustainable PET Value Chain

Fares Al‐Ostoot, Loredano Pollegioni, Elena Rosini

The rapid expansion of the global textile industry, driven by the fast-fashion paradigm, which is characterized by low-cost, short-lived garments made from inexpensive synthetic fibers, has intensified environmental pressures through increased waste generation, resource depletion, microplastic pollution, and greenhouse gas emissions. Conventional …

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Principles of NMDA receptor co-agonism at cortical fast-spiking GABAergic interneurons in the adolescent prefrontal cortex

Isis Nem de Oliveira Souza, Pierre Lecouflet, Zeynep Okur, Steeve Maldera et autres

Abstract N-methyl-D-aspartate receptors (NMDARs) populate fast-spiking (FS)-parvalbumin-positive (PV + ) GABAergic interneurons (INs), where they play a critical role in shaping circuit motifs and memory. However, it is largely unknown whether and how NMDARs at FS-PV + -INs are gated by their …

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Modulation of lipidomic and proteomic profile by diet composition in black soldier fly

Guido Domingo, Matteo Miceli, Daniele Bruno, Marco Orlando et autres

Abstract Within the framework of a circular bioeconomy, the valorisation of organic waste streams into high-value biomolecules represents a sustainable strategy to reduce environmental burdens while generating renewable resources. In this context, the black soldier fly ( Hermetia illucens , BSF) has …

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Bioinf-Farma: supervised integration of epitope prediction and recombinant protein developability for automated vaccine candidate prioritization

Heather Bondi, Matteo Crespi, Marco Orlando, Francesco Lescai et autres

Abstract Vaccine antigen discovery requires prioritizing protein candidates according to both immunogenic potential and recombinant expression feasibility. These properties are typically evaluated using separate computational tools, requiring researchers to integrate heterogeneous outputs through ad hoc workflows. Here, we present BIOINF-farma, a modular …

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Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder

Elisa Maffioli, Francesco Errico, Zoraide Motta, Raffaella di Vito et autres

Free D-serine (D-Ser) and D-aspartate (D-Asp) are increasingly recognized as key modulators of glutamatergic NMDA receptor-dependent neurotransmission, whose dysfunction has been implicated in neuropsychiatric conditions, including schizophrenia (SCZ) and autism spectrum disorder (ASD). The metabolism of these D-amino acids is tightly regulated …

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Bioeconomy Serious Play: An experiential learning approach to teaching bioeconomy in higher education and doctoral training

Loredano Pollegioni

The bioeconomy has become a strategic pillar of sustainable development, climate action, circular resource use, and innovation-driven growth. However, its inherent interdisciplinarity and systemic complexity pose substantial pedagogical challenges in higher education. Students and doctoral candidates must simultaneously understand scientific processes, industrial …

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A modular CRISPR-based E. coli platform for the sustainable upcycling of PET- and lignin-derived aromatic monomers to L-alanine

Alex Pessina, Mouna Attafi, Francesco Vaccaroni, Stefano Busti et autres

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A biotechnological platform for the valorization of textile waste blend

Erika Zangelmi, Nicolò Antonelli, Jacopo La Rocca, Gianluigi Broggini et autres

Textile waste is rapidly increasing worldwide due to rising clothing consumption and production. This study presents a novel, integrated green process for degrading and valorizing blended cotton-polyethylene terephthalate (PET) textile waste into value-added chemicals through enzymatic hydrolysis and microbial fermentation. To improve …

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Depolymerization of Polycotton‐Blended Fabrics: Challenges and Opportunities

Elena Rosini, Jorge J. G. Rocca, Camilla Loro, Gianluigi Broggini et autres

The rapid growth of the textile industry has led to a dramatic increase in fiber production and textile waste, with blended fabrics-particularly made of polyethylene terephthalate (PET) and cotton-dominating global markets. These blends combine the advantageous properties of synthetic and natural fibers …

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From wheat bran to 4-vinylguaiacol: A green bioprocess featuring in situ product recovery

Filippo Molinari, Alex Pessina, Stefano Busti, Marco Vanoni et autres

Valorizing agro-industrial byproducts such as wheat bran (WB) through microbial and enzymatic processing offers a sustainable route to high-value aromatic compounds like 4-vinylguaiacol (4VG). This study reports a novel one-pot biocatalytic system that couples the enzymatic hydrolysis of WB (UltrafloXL) - releasing …

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Valuable Compounds from Pollutants: Converting PET into Enantiopure Alanine

Elena Rosini, Caren Battaglia, Davide Miani, Filippo Molinari et autres

High Resolution Image Download MS PowerPoint Slide The enzymatic depolymerization of single-use plastic products, primarily made from poly(ethylene terephthalate) (PET), is now a reality. Herein, we report the development of an innovative tandem system process that uses engineered enzymes and Escherichia coli …

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Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni et autres

Introduction: Astrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP), recently proposed …

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