Hassan A. Zaidi

Ischemia modulation via coronary revascularization and effects on the arrhythmic substrate

Holly Porter Morgan, Amedeo Chiribiri, Marina Strocchi, Hassan A. Zaidi et autres

BACKGROUND: Coronary revascularization is frequently undertaken to reduce ischemia in patients with ischemic left ventricular (LV) dysfunction. Whether revascularization modulates the substrate for ventricular arrhythmia is unclear. OBJECTIVE: The study aimed to assess the effects of revascularization on arrhythmic substrate in ischemic …

gb, us (code pays fourni par la source)

Evaluating the Influence of LGE-CMR Scar Thresholds on Electrophysiology Simulation-Based Arrhythmic Risk Prediction

Ahmet Şen, Fernando Otaviano Campos, Richard Jones, Hassan A. Zaidi et autres

Fibrosis Entropy Is Associated With Life‐Threatening Arrhythmia in Nonischemic Cardiomyopathy

Daniel J. Hammersley, Hassan A. Zaidi, Richard E. Jones, Suzan Hatipoğlu et autres

Background Greater precision is required for arrhythmic risk stratification of patients with nonischemic cardiomyopathy (NICM). We sought to evaluate whether fibrosis entropy, a measure of scar texture heterogeneity derived from late gadolinium enhancement cardiovascular magnetic resonance, has incremental utility to fibrosis presence …

gb, no (code pays fourni par la source)

Myocardial Scar and Arrhythmic Risk Stratification in Ischemic Left Ventricular Systolic Dysfunction

Holly Porter Morgan, Amedeo Chiribiri, Muhummad Sohaib Nazir, Hassan A. Zaidi et autres

In Silico Trials for Sex-Specific patient Inclusion Criteria in Cardiac Resynchronization Therapy: Advancing Precision in Heart Failure Treatment.

Shuang Qian, Devran Uğurlu, Elliot Fairweather, Richard E. Jones et autres

Cardiac resynchronization therapy (CRT) guidelines are based on clinical trials with limited female representation and inconsistent left bundle branch block (LBBB) definitions. Conventional QRS duration (QRSd) criteria show variable diagnostic accuracy between sexes, partly due to differences in heart size and remodeling. …

gb, at, fr (code pays fourni par la source)

Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization

Shuang Qian, Devran Uğurlu, Elliot Fairweather, Laura Dal Toso et autres

Abstract Large-cohort imaging and diagnostic studies often assess cardiac function but overlook underlying biological mechanisms. Cardiac digital twins (CDTs) are personalized physics-constrained and physiology-constrained in silico representations, uncovering multi-scale insights tied to these mechanisms. In this study, we constructed 3,461 CDTs from …

gb, us, ch, at, fr (code pays fourni par la source)

Ischemia modulation via coronary revascularization and effects on the arrhythmic substrate

Holly Porter Morgan, Amedeo Chiribiri, Marina Strocchi, Hassan A. Zaidi et autres

Abstract Background Both ischemia and scar can contribute to arrhythmogenesis in patients with ischemic left ventricular dysfunction (ILVD); coronary revascularization is frequently undertaken to modify the former. Whether modulation of ischemia affects the substrate for ventricular arrhythmia is unclear. Objectives To assess …

gb, us (code pays fourni par la source)

PO-02-122 ELECTRO-ANATOMICAL AXIS SEPARATION PREDICTS RISK OF LEFT BUNDLE BRANCH BLOCK IN UK BIOBANK

Mohammad Kayyali, Hassan A. Zaidi, Ana Mincholé, John Whitaker et autres

The relative importance of ischaemia and scar in the genesis of ventricular arrhythmia in ischaemic cardiomyopathy

Holly Porter Morgan, Marina Strocchi, Azizah Puspitasari Ardinal, N.P. Wong et autres

Abstract Background Ventricular arrhythmias are a leading cause of death in patients with ischaemic cardiomyopathy (ICM). Ischaemia and scar are thought to contribute to arrhythmogenesis; as scar is considered fixed, strategies to reduce ischaemia such as revascularisation are undertaken to attempt to …

gb (code pays fourni par la source)

MP-470543-006 TOWARDS A GLOBAL ARRHYTHMIC RISK SCORE FOR ICD PLACEMENT IN ISCHEMIC HEART DISEASE INCORPORATING NOVEL COMPUTATIONAL-DERIVED BIOMARKERS

Hassan A. Zaidi, Richard Jones, Fernando Otaviano Campos, Shuang Qian et autres

PO-05-022 FAST IN-SILICO SUBSTRATE ASSESSMENT TO STRATIFY ARRHYTHMIC RISK IN ISCHEMIC HEART DISEASE

Hassan A. Zaidi, Richard G. Jones, Fernando Otaviano Campos, Pablo Lamata et autres

Predicting postinfarct ventricular tachycardia by integrating cardiac MRI and advanced computational reentrant pathway analysis

Pranav Bhagirath, Fernando Otaviano Campos, Hassan A. Zaidi, Zhong Chen et autres

BACKGROUND: Implantable cardiac defibrillator (ICD) implantation can protect against sudden cardiac death after myocardial infarction. However, improved risk stratification for device requirement is still needed. OBJECTIVE: The purpose of this study was to improve assessment of postinfarct ventricular electropathology and prediction of …

gb, nl, at (code pays fourni par la source)