Wilaiporn Saikruang

Programmable antibody-based chimeric entry receptors for sarbecoviruses

Yidan Wang, Conrad En Zuo Chan, Wilaiporn Saikruang, Adrian Eng Zheng Kang et autres

Despite frequent spillover of sarbecoviruses, most SARS-related viruses discovered in animals fail to engage human ACE2 (hACE2), limiting mechanistic insight and risk assessment. Here we developed antibody-based chimeric entry receptors (ABCERs) that reprogram antibody-antigen recognition into a synthetic, cell-anchored receptor interface. By …

cn, sg, jp, th, gb (code pays fourni par la source)

Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia

Supaporn Wacharapluesadee, Wilaiporn Saikruang, Spyros Lytras, Kanata Matsumoto et autres

By sampling horseshoe bats-the reservoir hosts of SARS-CoV-2-related coronaviruses (SC2r-CoVs)-in Thailand, we present two clades of SC2r-CoVs co-circulating in the same bat population. Through a comprehensive set of experimental approaches, including cryo-electron microscopy (cryo-EM), pseudovirus and live virus assays, and hamster experiments, …

th, jp, gb, hk, Égypte (code pays fourni par la source)

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi, Jumpei Ito et autres

The global circulation of SARS-CoV-2 in human populations has driven the emergence of Omicron subvariants, which have become highly diversified through recombination. In late 2024, SARS-CoV-2 Omicron XEC variant emerged from the recombination of two JN.1 progeny, KS.1.1 and KP.3.3, and became …

jp, us, sg, gb (code pays fourni par la source)

Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Kimura et autres

Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD …

jp, cz (code pays fourni par la source)

Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants

Hisano Yajima, Tomo Nomai, Kaho Okumura, Katsumi Maenaka et autres

Due to the incessant emergence of various SARS-CoV-2 variants with enhanced fitness in the human population, controlling the COVID-19 pandemic has been challenging. Understanding how the virus enhances its fitness during a pandemic could offer valuable insights for more effective control of …

jp, cz (code pays fourni par la source)

Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

Shigeru Fujita, Arnon Plianchaisuk, Sayaka Deguchi, Hayato Ito et autres

BACKGROUND: Although several SARS-CoV-2-related coronaviruses (SC2r-CoVs) were discovered in bats and pangolins, the differences in virological characteristics between SARS-CoV-2 and SC2r-CoVs remain poorly understood. Recently, BANAL-20-236 (B236) was isolated from a rectal swab of Malayan horseshoe bat and was found to lack …

jp, Égypte, hk, fr, ie (code pays fourni par la source)

The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter

Wilaiporn Saikruang, Lena Ang Yan Ping, Hiroto Abe, Dacquin M. Kasumba et autres

The human DEAD-box protein 3 (DDX3) has been reported as a positive regulator and functions in the induction of type I interferon signaling. We elucidated the function of DDX3 in the positive regulation of IFNB production in non-pDC cells. We found that …

jp, de (code pays fourni par la source)

Detection and genetic characterization of porcine astroviruses in piglets with and without diarrhea in Thailand

Kattareeya Kumthip, Pattara Khamrin, Wilaiporn Saikruang, Aphisek Kongkaew et autres

th, jp (code pays fourni par la source)

Comparative Evaluation of Norovirus Infection in Children with Acute Gastroenteritis by Rapid Immunochromatographic Test, RT-PCR and Real-time RT-PCR

Kattareeya Kumthip, Pattara Khamrin, Wilaiporn Saikruang, Kanittapon Supadej et autres

Immunochromatographic (IC) test for norovirus detection is a rapid and simple detection method. This study evaluated the sensitivity and specificity of a recent version of R-Biopharm RIDA®QUICK Norovirus IC assay for norovirus detection in fecal specimens from children hospitalized with acute gastroenteritis. …

th, jp (code pays fourni par la source)

Molecular detection and characterization of picobirnaviruses in piglets with diarrhea in Thailand

Lauren Wilburn, Arpaporn Yodmeeklin, Pakawat Kochjan, Wilaiporn Saikruang et autres

gb, th (code pays fourni par la source)

Complete genome analysis of a rare G12P[6] rotavirus isolated in Thailand in 2012 reveals a prototype strain of DS-1-like constellation

Wilaiporn Saikruang, Pattara Khamrin, Rungnapa Malasao, Kattareeya Kumthip et autres

th, jp (code pays fourni par la source)

Detection and characterization of Aichi virus 1 in pediatric patients with diarrhea in Thailand

Watchaporn Chuchaona, Pattara Khamrin, Arpaporn Yodmeeklin, Kattareeya Kumthip et autres

Kobuvirus is a newly discovered virus that belongs to the Kobuvirus genus in Picornaviridae family, which comprised of three species including Aichivirus A, Aichivirus B, and Aichivirus C. The kobuvirus isolated from human has been classified as Aichi virus 1 and belongs …

th, jp (code pays fourni par la source)