Erin Bell

Molecular Analyses of Polyamine Synthesis in Higher Plants

Russell L. Malmberg, Erin Bell

Polyamines and the polyamine-conjugates in plants have been correlated with a wide array of phenomena in higher plants 1 (also, see other chapters in this volume), yet it is difficult to precisely pin down what their specific role is in any physiological …

Weight of the evidence: independent research projects confirm industry conclusions on the safety of insect-protected maize MON 810

Jay S. Petrick, Erin Bell, Michael Koch

The cumulative weight of the evidence demonstrates the safety and equivalence of genetically engineered (GE) crops compared to the conventional varieties from which they have been derived. Confirmatory toxicology and animal nutrition studies have nevertheless become an expected/mandated component of GE crop …

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Effect of common processing of soybeans on the enzymatic activity and detectability of the protein, Dicamba Mono-Oxygenase (DMO), introduced into dicamba-tolerant MON 87708

Thomas C. M. Lee, Thomas C. Edrington, Erin Bell, Luis A. Burzio et autres

Assessing the safety of genetically engineered crops includes evaluating the risk (hazard and exposure) of consuming their newly expressed proteins. The dicamba monooxygenase (DMO) protein, introduced into soybeans to confer tolerance (DT) to dicamba herbicide, was previously characterized and identified to pose …

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Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure

Jaap H. Akkerdaas, Muriel Totis, Brian W. Barnett, Erin Bell et autres

BACKGROUND: Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions encountered …

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Stacked Genetically Engineered Trait Products Produced by Conventional Breeding Reflect the Compositional Profiles of Their Component Single Trait Products

Erin Bell, Shuichi Nakai, Luis A. Burzio

An expanding trend for genetically engineered (GE) crops is to cultivate varieties in which two or more single trait products have been combined using conventional breeding to produce a stacked trait product that provides a useful grouping of traits. Here, we report …

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Identification of GB1, a gene whose constitutive overexpression increases glycinebetaine content in maize and soybean

Paolo Castiglioni, Erin Bell, A. Lund, Alexander F. Rosenberg et autres

Abstract Efforts to increase glycinebetaine (GB) levels in plants have been pursued as an approach to improving plant performance under stress conditions. To date, the impact of engineered levels of GB has been limited by metabolic constraints that restrict the achieved increases. …

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Bringing New Plant Varieties to Market: Plant Breeding and Selection Practices Advance Beneficial Characteristics while Minimizing Unintended Changes

Kevin C. Glenn, Ben Alsop, Erin Bell, Mike E. Goley et autres

Commercial‐scale plant breeding is a complex process in which new crop varieties are continuously being developed to improve yield and agronomic performance over current varieties. A wide array of naturally occurring genetic changes are sources of new characteristics available to plant breeders. …

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Dicamba-Tolerant Soybeans (Glycine max L.) MON 87708 and MON 87708 × MON 89788 Are Compositionally Equivalent to Conventional Soybean

Mary L. Taylor, Anna Bickel, Rhonda M. Mannion, Erin Bell et autres

Herbicide-tolerant crops can expand both tools for and timing of weed control strategies. MON 87708 soybean has been developed through genetic modification and confers tolerance to the dicamba herbicide. As part of the safety assessment conducted for new genetically modified (GM) crop …

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Assessment of Natural Variability of Maize Lipid Transfer Protein Using a Validated Sandwich ELISA

Xin Gu, Thomas Lee, Tao Geng, Kang Liu et autres

Lipid transfer protein (LTP) is the main causative agent for rare food allergic reactions to maize. This paper describes a new, validated ELISA that accurately measures maize LTP concentrations from 0.2 to 6.4 ng/mL. The levels of LTP ranged from 171 to …

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Safety assessment of dicamba mono-oxygenases that confer dicamba tolerance to various crops

Cunxi Wang, Kevin C. Glenn, Colton R. Kessenich, Erin Bell et autres

Dicamba tolerant (DT) soybean, cotton and maize were developed through constitutive expression of dicamba mono-oxygenase (DMO) in chloroplasts. DMO expressed in three DT crops exhibit 91.6-97.1% amino acid sequence identity to wild type DMO. All DMO forms maintain the characteristics of Rieske …

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Additional file 2: of The cell surface mucin podocalyxin regulates collective breast tumor budding

Marcia L. Graves, Jane Cipollone, Pamela Austin, Erin Bell et autres

Is Movie S1 showing control MCF-7 cells present little collective invasion 3-D culture, and Movie S2 showing podo-overexpressing cells send out very dynamic processes and show considerable collective invasion in 3-D culture. (ZIP 2262 kb)

Additional file 1: of The cell surface mucin podocalyxin regulates collective breast tumor budding

Marcia L. Graves, Jane Cipollone, Pamela Austin, Erin Bell et autres

Is Figure S1 showing podocalyxin has little effect on subcutaneous tumor size a or proliferation in monolayer culture b, Figure S2 showing podocalyxin overexpression promotes local invasion of MCF-7 tumor cell xenografts,. Figure S3 showing that the ezrin inhibitor NSC668394 disrupts apical …