Teng Ge

Global, regional, and national burdens of non-rheumatic calcific aortic valve disease in middle-aged and elderly populations from 1990 to 2021 and predictions up to 2050: trends, predictions, and health inequity

Jinlin Hu, Teng Ge, Miao Zhang, Kanglai He et autres

AIM: The global incidence of non-rheumatic calcific aortic valve disease (NR-CAVD) is increasing annually owing to changes in the global population structure. We aimed to comprehensively assess the global disease burden and health inequity of NR-CAVD from 1990 to 2021 and predict …

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Bufalin alleviates myocardial ischemia-reperfusion injury by targeting PTGR2 to regulate NF-κB mediated inflammation

Jinlin Hu, Teng Ge, Jie Lin, Jian Bo et autres

INTRODUCTION: Myocardial ischemia-reperfusion injury (MIRI) significantly affects patient prognosis, with inflammation being a key pathogenic mechanism. OBJECTIVE: This study aimed to investigate the effect and mechanism of Bufalin in alleviating MIRI. METHODS: Using a murine MIRI model, we evaluated cardiac function, myocardial …

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Deciphering the influence of heavy metals on adverse cardiovascular events using machine learning

Guanmou Li, Tong Zhang, Kunyang He, Miao Zhang et autres

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Mitochondrial quality control as a therapeutic target in cardiovascular disease: Mechanistic insights and future directions

Miao Zhang, Tong Zhang, Rongjun Zou, Kanglai He et autres

Mitochondrial dysfunction is increasingly recognized as a critical driver in the pathogenesis of cardiovascular diseases. Mitochondrial quality control (MQC) is an ensemble of adaptive mechanisms aimed at maintaining mitochondrial integrity and functionality and is essential for cardiomyocyte viability and optimal cardiac performance …

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Evaluating the impact of metabolic indicators and scores on cardiovascular events using machine learning

Guanmou Li, Cheng Luo, Teng Ge, Kunyang He et autres

Cardiovascular diseases such as coronary artery disease, myocardial infarction, and heart failure impact millions of people annually globally and are a major cause of disease and death. This study explores the predictive capabilities of novel metabolic indices (TyG, HOMA-IR, TG/HDL-C, and VAI) …

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Dusp15 Dephosphorylates mtHsp70 at Thr116 to Prevent Its Proteasomal Degradation and Maintain Mitochondrial Unfolded Protein Response in Diabetic Cardiomyopathy

Xing Chang, Rongjun Zou, Jinlin Hu, Miao Zhang et autres

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Hyperglycemia-induced DNA damage response activates DNA-PK complex to promote endothelial ferroptosis in type 2 diabetic cardiomyopathy

Cheng Luo, Fang Chen, Rongjun Zou, Jingwei Jiang et autres

Our findings implicate the DNA-PK complex as a key regulator of hyperglycemia-induced endothelial ferroptosis in T2DM cardiomyopathy. Targeting DNA-PK complex may represent a novel therapeutic strategy for mitigating microvascular dysfunction and cardiac decline in T2DM.

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Natural products alleviate atrial fibrillation by modulating mitochondrial quality control

Teng Ge, Rongjun Zou, Miao Zhang, Jinlin Hu et autres

BACKGROUND: Atrial fibrillation (AF), one of the most common cardiac arrhythmias, is associated with high mortality rates and significant healthcare burdens. Mitochondrial homeostasis has recently emerged as a critical factor in AF pathogenesis but remains at the experimental stage. Current drug and …

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Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression

Xing Chang, Hao Zhou, Jinlin Hu, Teng Ge et autres

Atherosclerosis (AS) is a chronic vascular disease primarily affecting large and medium-sized arteries and involves various complex pathological mechanisms and factors. Previous studies have demonstrated a close association between atherosclerosis and inflammatory damage, metabolic disorders, and gut microbiota. It is also closely …

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Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells

Hongfei Qi, Teng Ge, Kun Wang, Jing Wang et autres

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Research status of pathogenesis of anxiety or depression after percutaneous coronary intervention and Traditional Chinese Medicine intervention

Bo Ning, Teng Ge, Qiangqiang Zhao, Lan-Shuan Feng et autres

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Role of Brain-Derived Neurotrophic Factor in Anxiety or Depression After Percutaneous Coronary Intervention

Bo Ning, Teng Ge, Yongqing Wu, Yuting Wang et autres

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