Accès ouvert
2026
article
OpenAlex
Adrián Klepe, Sonja Damberger, Ana Špilak, Andreas Brachner et autres
Ischemic stroke disrupts blood-brain barrier (BBB) integrity and alters small extracellular vesicle (sEV) signaling, yet the mechanisms underlying sEV transport across compromised barriers remain poorly understood. This study investigated BBB-sEV interactions under normal and stroke-mimicking oxygen/glucose deprivation (OGD) conditions using an in …
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Accès ouvert
2025
article
OpenAlex
Ana Špilak, Adrián Klepe, Heinz-Peter Friedl, Andreas Brachner et autres
BACKGROUND: Tumor-derived small extracellular vesicles (sEVs) have been implicated in changes of the blood-brain barrier (BBB) during pre-metastatic niche formation. Although it was postulated that sEVs can traverse the highly restrictive BBB via transcytosis-data mostly based on the indirect detection of transported …
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Accès ouvert
2025
article
OpenAlex
Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl et autres
Supplementary Material 1.
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Accès ouvert
2025
article
OpenAlex
Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl et autres
Supplementary Material 2.
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Accès ouvert
2024
article
OpenAlex
Ana Špilak, Andreas Brachner, Heinz-Peter Friedl, Adrián Klepe et autres
Small extracellular vesicles (sEVs) are an important part of intercellular communication. They are phospholipid bilayer particles that carry active biomolecules such as proteins, various nucleic acids, and lipids. In recipient cells, sEVs can alter cellular functions, including cancer development and premetastatic niche …
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Accès ouvert
2021
review
OpenAlex
Ana Špilak, Andreas Brachner, Ulrike Kegler, Winfried Neuhaus et autres
Early detection of cancer in order to facilitate timely therapeutic interventions is an unsolved problem in today's clinical diagnostics. Tumors are detected so far mostly after pathological symptoms have emerged (usually already in progressed disease states), within preventive screenings, or occasionally as …
at
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