Konstantinos Toutouzas

Redo‐Transcatheter Aortic Valve Implantation Versus Surgical Explantation in Patients With Previous Transcatheter Aortic Valve Implantation: A Systematic Review and Meta‐Analysis

Nikolaos Ktenopoulos, Anastasiοs Apostolos, Dimitrios Terentes‐Printzios, Maria Drakopoulou et autres

Background As transcatheter aortic valve implantation (TAVI) expands to younger and lower‐risk populations, failed transcatheter heart valves are increasingly encountered, yet the optimal reintervention strategy remains uncertain. This meta‐analysis aimed to compare the outcomes of redo‐TAVI (TAVI‐in‐TAVI) versus surgical transcatheter heart valve …

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Pharmacokinetics in the Fontan circulation: a multi-organ puzzle

Panayotis K. Vlachakis, Maria Drakopoulou, Panagiotis Theofilis, Paschalis Karakasis et autres

Patients with Fontan circulation represent a pharmacologically distinct population in whom the haemodynamic consequences of single-ventricle physiology alter every phase of drug disposition in ways that current prescribing practice systematically fails to account for. Fontan-associated liver disease suppresses hepatic CYP enzyme activity …

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Multimodality echocardiography in structural heart disease: the evolving role of the interventional imager

Nikolaos Ktenopoulos, Konstantina Vlasopoulou, Panayotis Vlachakis, Anastasiοs Apostolos et autres

Over the last decade, transcatheter structural heart interventions (TSHIs) have revolutionized the management of patients with structural heart disease (SHD), particularly those deemed high-risk or inoperable for conventional surgery. This rapid evolution has been propelled by innovations in both device technology and …

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Conduction system pacing for cardiac resynchronization therapy: a systematic review

Georgios Fotos, Nikolaos Ktenopoulos, Konstantinos Vlachos, Apostolos Christou et autres

Biventricular pacing (BVP) remains the standard method for delivering cardiac resynchronization therapy (CRT) in patients with heart failure and left bundle branch block (LBBB). Despite its established role, BVP is a non-physiological pacing approach and is limited by factors such as anatomical …

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Cardiovascular primary prevention in Greece

Konstantinos Toutouzas, Panayotis K. Vlachakis, G Kochiadakis

The term ‘Prolamvano’ (Προλαμβάνω) originates from ancient Greek and denotes the act of anticipating or preventing an adverse event before its occurrence. Embedded in classical Greek medical philosophy and the Hippocratic tradition, the concept reflects a fundamental principle of medicine: that prevention …

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A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection

Christos Psarrakis, Nikolaos-Renatos Tziolos, Vicky Matzarakis, Vinod Kumar et autres

Early risk recognition for organ dysfunction and death by Clostridioides difficile infection (CDI) is an unmet need. A prediction score is developed in the BEYOND study (ClinicalTrials.gov; NCT02573571, NCT04725123, and NCT05304715). At the first stage, using 153 patients and 150 comparators, the …

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Clinical Outcomes of Transcatheter Versus Surgical Management of Coronary Artery Disease and Aortic Stenosis

Nikolaos Ktenopoulos, Anastasiοs Apostolos, Konstantinos Karampinos, Panayotis K. Vlachakis et autres

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1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis

Patrick Serruys, Akihiro Tobe, Niels van Royen, Ignacio J. Amat‐Santos et autres

BACKGROUND: In the LANDMARK trial, the Myval balloon-expandable transcatheter heart valve (THV) series was noninferior to the most commonly used contemporary SAPIEN and Evolut Series THVs for the 30-day early safety endpoint in participants with symptomatic severe native aortic stenosis. OBJECTIVES: The …

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Conversion to Cardiac Surgery During Elective and Urgent Transcatheter Aortic Valve Implantation: A Systematic Review and Meta‐Analysis

Nikolaos Ktenopoulos, Anastasiοs Apostolos, Dimitrios‐David Chlorogiannis, Ioannis Kachrimanidis et autres

Transcatheter aortic valve implantation (TAVI) has become an established treatment for severe aortic stenosis. However, the need for unplanned conversion to cardiac surgery (CS) during TAVI remains an infrequent but critical event. It is unclear whether this risk is higher in patients …

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A multifaceted clinical portrait of Ebstein’s anomaly: a case series

Panayotis K. Vlachakis, Eva Nyktari, Anastasiοs Apostolos, Skevos Sideris et autres

Background: It was in 1866 when Wilhelm Ebstein first described a rare case of a 19-year-old cyanotic patient with tricuspid valve regurgitation caused by a congenital malformation. Since then, Ebstein's anomaly (EA) has been recognized as a condition that exhibits a diverse …

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Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut THVs: insights from LANDMARK trial

Osama Soliman, Elfatih A. Hasabo, Niels van Royen, Ignacio J. Amat‐Santos et autres

AIMS: Several factors, including device design, annulus size, and sizing strategies, influence transcatheter heart valve (THV) haemodynamic outcomes in patients with aortic stenosis (AS). This sub-study evaluates early (30-day) echocardiographic outcomes of the Myval, Sapien, and Evolut THV series, focusing on haemodynamic …

ie, au, nl, es, sk, si, ee, hr, hu, gr, pl, br, us, pt, fr, de, it, nz, se, in, gb (code pays fourni par la source)

Neuroprotection after Cardiac Arrest: Reevaluating the Role of Therapeutic Hypothermia – A Narrative Review

George Latsios, Elias Sanidas, Maria Velliou, George Nikitas et autres

Therapeutic hypothermia, defined as lowering the core body temperature to 32°C–34°C, has emerged as a key intervention in post-cardiac arrest care, aimed at mitigating brain injury and improving neurological outcomes. The primary pathways underlying the potential neuroprotective effects of therapeutic hypothermia include …

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