Agnès Caille

Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial

Floriane Le Vilain–Abraham, Jean-Michel Halimi, Patrick Rossignol, Maurice Laville et autres

INTRODUCTION: Hypertension is the primary modifiable risk factor for cardiorenal complications of chronic kidney disease (CKD). It is well established that lowering blood pressure (BP) in patients with CKD reduces renal and cardiovascular complications. The guidelines advise starting the BP-lowering drug with …

fr, mc (code pays fourni par la source)

Reducing Bias in Cluster Randomized Trials in Nephrology

Jessica Kasza, Gabor Mihala, Agnès Caille, Rhys Bowden

Cluster Randomized Trials in NephrologyCluster randomized trials are an important class of randomized controlled trials.Instead of randomizing individual participants, cluster randomized trials randomize entire groups (clusters) of participants.These trials are useful when assessing the effects of interventions applied at a cluster level …

au, fr (code pays fourni par la source)

Revisiting septic cardiomyopathy: the missing role of systolic function in interpreting diastolic dysfunction and outcomes. Author's reply

Philippe Vignon, JJ Léger, Julien Vaidie, Agnès Caille et autres

fr (code pays fourni par la source)

A Preliminary Report: Screening Idiopathic Scoliosis (IS) With a Smartphone Application

Paul Martrenchar, Agnès Caille, Antonios Dina, Thierry Odent

INTRODUCTION: Idiopathic scoliosis (IS) is a 3-dimensional spinal deformity that affects ∼3.1% of the population. Current strategies for IS screening and management remain limited resulting in delayed detection and inconsistent follow-up, which can result in missed opportunities for conservative treatment and an …

fr (code pays fourni par la source)

Intrapartum group B streptococcus (GBS) detection by intrapartum PCR versus antenatal culture at 35-38 weeks of gestation: Justification for a crossover, cluster randomized controlled trial, and protocol summary

Marine Godfroy, Agnès Caille, Isabelle Durand‐Zaleski, Pauline Scherdel et autres

fr (code pays fourni par la source)

Restricted mean survival time in cluster randomized trials with a small number of clusters: Improving variance estimation of the intervention effect from the pseudo-values regression

F. Le Vilain-Abraham, Solène Desmée, JA Thompson, Jean-Claude Lacherade et autres

In randomized clinical trials with a time-to-event outcome, the intervention effect could be quantified by a difference in restricted mean survival time (ΔRMST) between the intervention and control groups, defined as the expected survival duration gain due to the intervention over a …

fr, gb (code pays fourni par la source)

High Psychological Impact of Covid‐19 on French Healthcare Workers: An Observational Cohort Study of PTSD, Depression and Burn‐Out

Wissam El‐Hage, Myriam Blanchin, Éric Bui, Hala Kerbage et autres

INTRODUCTION: The Covid-19 outbreak hit the world forcing public institutions to rethink their core functioning. Healthcare workers (HCWs) were particularly at risk for negative mental health outcomes, given their direct exposure to many pandemic-related stressors. Our study aimed to assess the psychological …

fr (code pays fourni par la source)

Affective Symptoms and Amyloid Plaques: Antidepressant Response and Clinical Outcome Associated With Brain Amyloid Load in a 2-Year Cohort of Nondemented Older Adults With Depression—The ASAP Study

Thomas Desmidt, Maria-João Santiago-Ribeiro, Gabriel Robert, Frédéric Blanc et autres

fr, mc, ch (code pays fourni par la source)

Guidelines for the content of statistical analysis plans in clinical trials: protocol for an extension to cluster randomized trials

Karla Hemming, Jacqueline Thompson, Jacqueline Y. Thompson, Richard L. Hooper et autres

BACKGROUND: Guidance exists to inform the content of statistical analysis plans in clinical trials. Though not explicitly stated, this guidance is generally focused on clinical trials in which the randomization units are individual patients and not groups of patients. There are critical …

gb, us, fr, Gambie, au, ca (code pays fourni par la source)

Quilting Suture Without Drainage or Conventional Closure with Drainage for Breast Cancer Mastectomy: A Randomized Controlled Trial

Lobna Ouldamer, Bruno Giraudeau, F. Dravet, Cédric Nadeau et autres

fr, us (code pays fourni par la source)

Evaluation of efficacy and safety of rituximab in patients with progressive interstitial lung disease (ILD) with inflammatory component (EvER-ILD2): A multicentre double-blind placebo-controlled randomized trial

Marion Ferreira, Théodora Bejan‐Angoulvant, S. Marchand‐Adam, Elodie Mousset et autres

fr (code pays fourni par la source)

A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials

Guangyu Tong, Pascale Nevins, Mary Ryan, Kendra Davis‐Plourde et autres

BACKGROUND/AIMS: Stepped-wedge cluster randomized trials tend to require fewer clusters than standard parallel-arm designs due to the switches between control and intervention conditions, but there are no recommendations for the minimum number of clusters. Trials randomizing an extremely small number of clusters …

us, ca, fr (code pays fourni par la source)