Xin Niu

Oral Fluid Concentrations of Tenofovir and Emtricitabine for Monitoring HIV Antiretroviral Adherence: Findings From a Randomized Trial with Directly Observed Therapy (TARGET Study)

Xin Niu, Tiancheng E. Edwards, Jeannette A Dienhart, Richard E. Haaland et autres

Background: Early identification of non-adherence to daily antiretroviral therapies may facilitate targeted transition to long-acting HIV regimens for individuals most likely to benefit. This study evaluated the feasibility of detecting emtricitabine (FTC) and tenofovir (TFV) in oral fluids to monitor daily oral …

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Diagnostic Accuracy of Fall Risk Screening Tools in Older Individuals: A Systematic Review With Bivariate Random-Effects Meta-Analysis

Zhongxu Hu, Xianyang Xin, Xin Niu, Shiya Chen et autres

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P3.13.24 Longitudinal Plasma Proteomics Identifies Predictive Biomarkers for Anti-PD-L1 Therapy in SCLC

Jim Zhong, Xin Niu, Liyan Xia, Shun Lü

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Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?

Xin Niu, Derin Sevenler, Sandy Dossantos, Mehmet Toner et autres

Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high …

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Is Lenacapavir Needed for Individuals Adherent to Daily Oral PrEP?

Xin Niu, Paul K. Drain

This Viewpoint discusses the potential advantages of injectable preexposure prophylaxis (PrEP) drugs such as lenacapavir for persons unable to adhere to daily oral HIV PrEP and highlights ways in which lenacapavir and expanded PrEP options could offer tailored and effective ways to …

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Real-world diagnostic accuracy of lipoarabinomannan in three non-sputum biospecimens for pulmonary tuberculosis disease

Xin Niu, Adrienne E. Shapiro, Zanele P. Magcaba, Zinhle Ngcobo et autres

Background Development of a non-sputum test using readily-obtainable biospecimens remains a global priority for tuberculosis (TB) control. We quantified lipoarabinomannan (LAM) concentrations, a pathogen biomarker for Mycobacterium tuberculosis , in urine, plasma and serum for real-world diagnostic accuracy of pulmonary TB among …

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A DBN-BPNN Cascade-Model for Electrical Equipment Quality Assessment

Yufang Liang, Xin Niu, Long Jie Zhang, Kai Guo et autres

The current power equipment quality assessment model is primarily nonlinear and involves a wide range of data, making it challenging to precisely determine the intrinsic connection between the equipment's operational data and its quality level. Challenges such as strong subjectivity and poor …

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Adherence and HIV Protection Thresholds for Emtricitabine and Tenofovir Disoproxil Fumarate Preexposure Prophylaxis among Cisgender Women: A Systematic Review

Linxuan Wu, Xin Niu, Marisa Kaitlin Brunelli, Kenneth K. Mugwanya

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Classification Algorithms in Automatic Diagnosis of ECG Arrhythmias: A Review

Haibo Sun, Dan Luo, Xin Niu, Xiaoxi Zeng et autres

ECG (Electrocardiogram), the most commonly used tool in the diagnosis of cardiac diseases, contains a large amount of physiologic information about the electrical activity of the heart. Research on automatic diagnosis of cardiac diseases by means of computer-aided ECG diagnosis has been …

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Measurement of Antiretrovirals in Blood, Urine and Oral Fluids for Oral Preexposure Prophylaxis Adherence Monitoring

Xin Niu

Thesis (Ph.D.)--University of Washington, 2024

No extraction? No problem. Direct to PCR processing of tongue swabs for diagnosis of tuberculosis disease as an alternative to sputum collection

Charlotte L. Ahls, Duncan Emsweller, Seth J. Helfers, Xin Niu et autres

ABSTRACT Sputum collection and testing for tuberculosis (TB) have been problematic due to the potential for aerosolization, difficulty in generating a quality sample, and complex DNA extraction methods. Tongue swabs are inexpensive, minimally invasive, and a promising alternative to sputum collection. We …

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Is Higher Adherence Required for Women Using Oral Emtricitabine/Tenofovir Disoproxil Fumarate for Human Immunodeficiency Virus Preexposure Prophylaxis?

Xin Niu, Paul K. Drain

To the Editor—Anderson et al utilized tenofovir-diphosphate (TFV-DP) data from the oral preexposure prophylaxis (PrEP) arms in Human Immunodeficiency Virus (HIV) Prevention Trials Network (HPTN) 083 (men) and HPTN 084 (women) studies to estimate the adherence-response relationship for oral Emtricitabine/Tenofovir Disoproxil Fumarate …

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