Selva Zamanzadeh

Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela

Elnaz Nakhjiri, Shaqayeq Roqanian, Hamid Soltani Zangbar, Manuchehr Seyedi Vafaee et autres

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Pathogenic cis p-tau levels in CSF reflects severity of traumatic brain injury

Alireza Mohsenian Sisakht, Najme Karamzade‐Ziarati, Amin Jahanbakhshi, Koorosh Shahpasand et autres

Traumatic brain injury (TBI) is the main cause of death and disability among young people. Following TBI, immune system activation and cytokine release induce kinase activity and hyperphosphorylation of tau protein, a structural molecule in axonal microtubules. The cis configuration of phosphorylated …

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Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela

Elnaz Nakhjiri, Shaqayeq Roqanian, Hamid Soltani Zangbar, Manuchehr Seyedi Vafaee et autres

Abstract Spinal cord injury (SCI) can lead to neurological impairment with significant functional and cognitive deficits. It is obvious that SCI causes focal neurodegeneration that gradually expands to the other cord areas. On the other hand, it is clear that traumatic brain …

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cis pT231-Tau Drives Neurodegeneration in Bipolar Disorder

Roghayeh Naserkhaki, Selva Zamanzadeh, Hossein Baharvand, Seyed Massood Nabavi et autres

Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. It remains uncertain how tau hyperphosphorylation results in neurodegeneration …

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