David H. Wasserman

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Natasha Jaiswal, M P Gavin, Louise Lantier, Olivia Yu Yu Ong et autres

ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of …

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Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance

Morgan Kindel, Ryan J. Post, Kyle Grose, Louise Lantier et autres

Repeated exercise produces robust physiological benefits and is the leading lifestyle intervention for human health. The benefits from exercise training result from the remodeling of skeletomuscular, cardiovascular, metabolic, and endocrine systems. In mice, we find that activation of the central nervous system …

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α-Parvin promotes glucose uptake and metabolism in skeletal muscle with minimal influence on hepatic insulin sensitivity

Fabian Bock, Xinyu Dong, Kakali Ghoshal, David A. Cappel et autres

Skeletal muscle and liver insulin resistance are early features in the sequelae of type 2 diabetes. Integrins are extracellular matrix receptors expressed on skeletal muscle cells and hepatocytes, which have been implicated in modulating obesity-associated insulin resistance. Integrins regulate cell function through …

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α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity

Fabian Bock, David A. Cappel, Xinyu Dong, J. William Deaver et autres

Skeletal muscle and liver insulin resistance are early features in the sequelae of type 2 diabetes. Integrins are extracellular matrix receptors expressed on skeletal muscle cells and hepatocytes and have been implicated in modulating obesity-associated insulin resistance. Integrins regulate cell function through …

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Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity

Nathan C. Winn, David A. Cappel, Ethan D. Pollack, Louise Lantier et autres

This study used pharmacological gain-of-function and genetic loss-of-function approaches to test the hypothesis that the eNOS/NO/cGMP axis is central to exercise training adaptations in microcirculatory function and exercise capacity. Chronic but not acute treatment with the PDE5 inhibitor, sildenafil, synergizes with exercise …

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Persistent Postirradiation Skeletal Muscle Protein and Insulin Sensitivity Changes in Nonhuman Primates

Jingyun Lee, Xiaofei Chen, Katherine M. Fanning, Si Chen et autres

Increased incidence of diabetes has been reported after whole-body irradiation in cancer survivors and in the years after exposure in research studies of nonhuman primates. Type 2 diabetes presents in the absence of obesity and suggests that skeletal muscle, the predominant organ …

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Metastability of stratified magnetohydrostatic equilibria and their relaxation

David N. Hosking, David H. Wasserman, S. C. Cowley

Motivated by explosive releases of energy in fusion, space and astrophysical plasmas, we consider the nonlinear stability of stratified magnetohydrodynamic equilibria against two-dimensional interchanges of straight magnetic-flux tubes. We demonstrate that, even within this restricted class of dynamics, the linear stability of …

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The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function

Alexander E. Sullivan, Meaghan CS Courvan, Aaron W. Aday, David H. Wasserman et autres

BACKGROUND: Elevated serum free fatty acid (FFA) concentration is associated with insulin resistance and is a hallmark of metabolic syndrome. A pathological feature of insulin resistance is impaired endothelial function. OBJECTIVE: To investigate the effect of FFA reduction with either acipimox, a …

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Sex- and endurance training-mediated cardiovascular protection through lipids during exercise

Julia An, Ariel S. Thorson, David H. Wasserman, John M. Stafford

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Abstract 4143433: Vascular Determinants of Functional Capacity in Peripheral Artery Disease

Alexander E. Sullivan, Adam Behroozian, Emily Shardelow, Emily K. Smith et autres

Background: Patients with peripheral artery disease (PAD) experience walking impairment that is incompletely explained by conduit artery atherosclerotic occlusive disease and ankle-brachial index (ABI). Microvascular dysfunction is associated with adverse outcomes including amputation but its effect on ambulation is unknown. We tested …

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Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency

Cyndya A. Shibao, Vivek S. Peche, Terri Pietka, Dmitri Samovski et autres

AIMS/HYPOTHESIS: Microvascular dysfunction contributes to insulin resistance. CD36, a fatty acid transporter and modulator of insulin signalling, is abundant in microvascular endothelial cells. Humans carrying the minor allele (G) of CD36 coding variant rs3211938 have 50% reduced CD36 expression and show endothelial …

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Endothelial β1-integrins are necessary for microvascular function and glucose uptake

Nathan C. Winn, Deborah A. Roby, P. Mason McClatchey, Ian M. Williams et autres

The microvasculature is an important site of resistance to muscle glucose uptake. We show that microvasculature integrins determine the exchange of glucose between the circulation and muscle. Specifically, a 30% reduction in the expression of endothelial integrin β1 subunit is sufficient to …

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