Accès ouvert
2026
article
OpenAlex
María Ángeles Peinado, Santos Blanco, Ángela Naranjo, María del Mar Muñoz et autres
Ischemic stroke, a leading cause of disability and mortality, initiates a complex damage cascade within the neurovascular unit (NVU), leading to blood-brain barrier (BBB) disruption and neuroinflammation that severely exacerbates secondary injury. Neuroglobin (Ngb), an endogenous protein induced by brain injury, represents …
es, fi
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Accès ouvert
2024
article
OpenAlex
Ángela Naranjo, M. Josefa Álvarez-Soria, P. Aranda-Villalobos, Ana María Martínez-Rodríguez et autres
Hydroxytyrosol (HT) is a bioactive olive oil phenol with beneficial effects in a number of pathological situations. We have previously demonstrated that an HT-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic-stroke-associated damage in mice. Our exploratory pilot study …
es
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2023
article
OpenAlex
Jesús Calahorra, Salomé Araujo‐Abad, José M. Granadino‐Roldán, Ángela Naranjo et autres
In solid tumors, such as breast cancer, hypoxic microenvironment worsens patient prognoses. We have previously reported in MCF-7 breast cancer cells that, under hypoxic conditions, hydroxytyrosol (HT) downregulates the level of reactive oxygen species, reduces the expression of hypoxia inducible factor-1α (HIF-1α), …
es
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Accès ouvert
2022
article
OpenAlex
Carlos Moreno‐Castilla, Ángela Naranjo, María Victoria López‐Ramón, Eva Siles et autres
Peroxidase-mimicking activity of manganese ferrite nanoparticles was studied, based on the oxidation of TMB (3,3′,5,5′-tetramethylbenzidine) by H2O2 at pH 4 using acetate and citrate buffers. The aim of this study was to examine this reaction not only by enzymology (Michaelis-Menten kinetics model) …
es
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Accès ouvert
2022
article
OpenAlex
Santos Blanco, Esther Martínez‐Lara, Eva Siles, María Ángeles Peinado
Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels. Therefore, its …
es
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Accès ouvert
2021
article
OpenAlex
Juan-Luis Peñas-Fuentes, Eva Siles, Eva E. Rufino‐Palomares, Amalia Pérez‐Jiménez et autres
Erythrodiol (EO) is a pentacyclic triterpenic alcohol found in olive tree leaves and olive oil, and it has important effects on the health properties and quality of olive oil. In this study, we characterized the cytotoxic effects of EO on human hepatocarcinoma …
es
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Accès ouvert
2021
article
OpenAlex
María Ángeles Peinado, David Ovelleiro, María Luisa del Moral, Raquel Hernández et autres
Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood–brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified …
es
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Accès ouvert
2021
article
OpenAlex
Francisco José Julián-Villaverde, Laura Ochoa‐Callejero, Eva Siles, Esther Martínez‐Lara et autres
Hemorrhagic stroke remains an important health challenge. Adrenomedullin (AM) is a vasoactive peptide with an important role in cardiovascular diseases, including stroke. Serum AM and nitrate–nitrite and S-nitroso compounds (NOx) levels were measured and compared between healthy volunteers (n = 50) and …
es
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Accès ouvert
2021
article
OpenAlex
Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth et autres
microglia/macrophages in the post-ischemic area, inducing higher expression of anti-inflammatory markers while no clear-cut effect was observed. Also, HT did not affect recovery of the cerebrovascular parameters, including ADC and CBF. Altogether, our data indicated that a prolonged dietary intervention with HT, …
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Accès ouvert
2020
article
OpenAlex
Gloria C. Bonel-Pérez, Amalia Pérez‐Jiménez, Isabel Gris-Cárdenas, Alberto M. Parra‐Perez et autres
Natural products have a significant role in the development of new drugs, being relevant the pentacyclic triterpenes extracted from Olea europaea L. Anticancer effect of uvaol, a natural triterpene, has been scarcely studied. The aim of this study was to understand the …
es, de
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Accès ouvert
2020
article
OpenAlex
Jorge A. Ramírez‐Tejero, Esther Martínez‐Lara, María Ángeles Peinado, María Luisa del Moral et autres
Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of …
es
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Accès ouvert
2020
preprint
OpenAlex
Gloria C. Bonel-Pérez, Amalia Pérez‐Jiménez, Isabel Gris-Cárdenas, Alberto M. Parra‐Perez et autres
Natural products have a significant role in the development of new drugs, being relevant the pentacyclic triterpenes extracted from Olea europaea. Anticancer effect of uvaol, a natural triterpene, has been scarcely studied. The aim of this study was to understand the anticancer …
es, de
(code pays fourni par la source)