Yoshiaki Nishio

Immunological Profiling of Leukocyte Subset Proportions and Novel Blood Biomarkers in the Acute Phase of Ocular Sarcoidosis and Vogt–Koyanagi–Harada Disease: An Exploratory Pilot Study

Tomohito Sato, Yuki Takenaka, Yoshiaki Nishio, Masataka Ito et autres

Aberrant pathogenic immune responses drive autoimmune uveitides; however, comprehensive leukocyte profiling in the conditions remains limited. Here, this exploratory pilot study aimed to elucidate the immunodynamics of ocular sarcoidosis (OS) and Vogt–Koyanagi–Harada disease (VKH) to identify blood diagnostic biomarkers during their acute …

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Enhanced M2 Polarization of Retinal Microglia in Streptozotocin-Induced Diabetic Mice upon Autoimmune Stimulation

Yoshiaki Nishio, Hideaki Someya, Kozo Harimoto, Tomohito Sato et autres

Background: This study aimed to investigate the impact of the diabetic environment on the development of experimental autoimmune uveoretinitis (EAU) and the activation status of microglia in the eye. Methods: EAU was induced in wild-type (WT) and streptozotocin (STZ)-induced diabetic mice (STZ-EAU …

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Anti-inflammatory actions of ripasudil ameliorate experimental autoimmune uveoretinitis in the acute phase

Kozo Harimoto, Yoshiaki Nishio, Hideaki Someya, Tomohito Sato et autres

INTRODUCTION: Rho-associated protein kinases (ROCKs) are a key regulator of T cell function, influencing a wide range of processes from activation to differentiation. Experimental autoimmune uveoretinitis (EAU) is an animal model of human non-infectious uveitis. This study aimed to evaluate the suppressive …

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Anterior Chamber Flare as a Non-Invasive Assessment of Intraocular Immune Status and Ocular Complications in Proliferative Diabetic Retinopathy

Tomohito Sato, Yuki Takenaka, Yoshiaki Nishio, Masataka Ito et autres

Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Anterior chamber (AC) flare and intraocular cytokines are potent biomarkers reflecting the intraocular immune status in PDR. This study aimed to elucidate the complex interrelationship between AC flare and intraocular …

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Autoimmune uveitis attenuated in diabetic mice through imbalance of Th1/Th17 differentiation via suppression of AP-1 signaling pathway in Th cells

Masaru Takeuchi, Yoshiaki Nishio, Hideaki Someya, Tomohito Sato et autres

Purpose: Inflammation is involved in the pathogenesis of diabetes, however the impact of diabetes on organ-specific autoimmune diseases remains unexplored. Experimental autoimmune uveoretinitis (EAU) is a widely accepted animal model of human endogenous uveitis. In this study, we investigated the effects of …

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Classification of Peripheral Blood Leukocyte Phenotypes and Serum Cytokines in Vogt–Koyanagi–Harada Disease before and after Glucocorticoid Therapy

Tomohito Sato, N. Taniguchi, Yoshiaki Nishio, Masataka Ito et autres

Vogt–Koyanagi–Harada disease (VKH) is an autoimmune disease, and glucocorticoid therapy (GC) is widely used for VKH. We provided a profile of leukocyte populations and serum cytokines in VKH patients under GC. A prospective observational study was conducted on three treatment-naïve VKH patients. …

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Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy

Tomohito Sato, Rina Okazawa, Koichi Nagura, Hideaki Someya et autres

Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, the associations between systemic factors and VF cytokines and their influence …

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Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway

Hideyuki Shimizu, Kei Takayama, Kazuhisa Yamada, Ayana Suzumura et autres

The purpose of this study is to investigate the protective effect of dimethyl fumarate (DMF), the methyl-ester of fumaric acid, against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. ARPE-19 cells, a human RPE cell line, were cultured with DMF followed …

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Case report: Bilateral panuveitis resembling Vogt-Koyanagi-Harada disease after second dose of BNT162b2 mRNA COVID-19 vaccine

Tomohito Sato, Ryotaro Nihei, Daisuke Sora, Yoshiaki Nishio et autres

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a serious pandemic. COVID-19 vaccination is urgent needed for limiting SARS-CoV-2 outbreaks by herd immunity. Simultaneously, post-marketing surveillance to assess vaccine safety is important, and collection of vaccine-related …

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Osteopontin-induced vascular hyperpermeability through tight junction disruption in diabetic retina

Hideaki Someya, Masataka Ito, Yoshiaki Nishio, Tomohito Sato et autres

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Photodynamic therapy with 5-aminolevulinic acid: A new diagnostic, therapeutic, and surgical aid for neuroblastoma

Toshihiko Watanabe, Yoshiaki Nishio, Yuki Yamamoto, Takahiro Shimizu et autres

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Correlation of physical aging and glass transition temperatures in ultrathin polystyrene films supported on SiO2

Tulika Sharma, Yoshiaki Nishio, Yuichiro Tamano, Harumi Sato et autres

This study examined the effects of the aging temperature ( T age ) on structural relaxation in ultrathin-supported polystyrene (PS) films with thickness ~0.2Rg. X-ray reflectivity and differential scanning calorimetry were used to evaluate the glass transition temperature ( T g ) …

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