Sharon Westcar

Experiences of conducting effective Patient and Public Involvement and Engagement (PPIE) by the WILL Trial (When to Induce Labour to Limit risk in pregnancy hypertension) management team

Katie Kirkham, Sue Tohill, Julie Wade, Clive Stubbs et autres

BACKGROUND: Patient and Public Involvement and Engagement (PPIE) is an essential element of any clinical trial, to ensure that the research design and resources are acceptable and the trial produces findings that are relevant to research participants and service-users. The WILL (When …

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Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation

Daniel C Perry, Juul Achten, Alex Zimmermann, Rebecca Kandiyali et autres

BACKGROUND: Displaced medial epicondyle fractures are among the most controversial injuries in children, with increasing trends towards surgical fixation despite little supporting evidence. Approximately half of affected children undergo surgical fixation, while others receive non-surgical care. The SCIENCE trial aimed to determine …

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A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants

Mari Johnson, Irina Chelysheva, Deniz Öner, Joseph McGinley et autres

BACKGROUND: Respiratory syncytial virus (RSV) is a significant cause of infant morbidity and mortality worldwide. Most children experience at least one 1 RSV infection by the age of two 2 years, but not all develop severe disease. However, the understanding of genetic …

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Persistence of Antibody Response Following a Booster Dose of Hib-MenC-TT Glycoconjugate Vaccine to Five Years

Ameneh Khatami, Matthew D. Snape, Jacek Wysocki, Tessa M. John et autres

BACKGROUND: Antibodies against Haemophilus influenzae type b (Hib) and serogroup C Neisseria meningitidis (MenC) persist better to 3½ years of age after a 12-month booster dose of a combination Hib-MenC glycoconjugate vaccine (Hib-MenC-TT) in children primed in infancy with Hib-MenC-TT and diphtheria-tetanus-acellular-pertussis-inactivated …

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Antipyretic use after infant immunization

Sharon Westcar, Karen Ford, Sarah Kelly, Matthew D. Snape

Sharon Westcar, Karen Ford, Sarah Kelly and Matthew Snape compare the effectiveness of ibuprofen and paracetamol on treating adverse reactions after immunization

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Persistence of Antibody Response Following a Booster Dose of Hib-MenC-TT Glycoconjugate Vaccine to Five Years

Ameneh Khatami, Snape, Jacek Wysocki, Tessa M. John et autres

Persistence of Immunity Following a Booster Dose of Haemophilus Influenzae Type B-Meningococcal Serogroup C Glycoconjugate Vaccine

Ameneh Khatami, Matthew D. Snape, Tessa M. John, Sharon Westcar et autres

BACKGROUND: Antibodies against Haemophilus influenzae type b (Hib) and serogroup C Neisseria meningitidis (MenC) wane after early infant immunization. METHODS: Children previously immunized in a randomized controlled trial at ages 2, 3, and 4 months with DTPa-IPV-Hib and MenC-CRM197 (MenC-CRM group) or …

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A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial

David Pace, Matthew D. Snape, Sharon Westcar, Claire Oluwalana et autres

OBJECTIVE: To study the immunogenicity and reactogenicity of a combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine (Hib-MenC-TT) when administered as a booster dose in combination with a measles, mumps and rubella vaccine (MMR). DESIGN: A …

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Influenza: an overview with a paediatric focus.

Sharon Westcar, Tracey Chantler

Influenza is a viral infection which affects people of all ages, it is usually a self-limiting disease but it can lead to complications. This article gives an overview of influenza, looking at the disease and its possible complications. It gives a brief …

Serotype-Specific and Age-Dependent Generation of Pneumococcal Polysaccharide-Specific Memory B-Cell and Antibody Responses to Immunization with a Pneumococcal Conjugate Vaccine

Elizabeth Clutterbuck, Sarah Oh, Mainga Hamaluba, Sharon Westcar et autres

Glycoconjugate vaccines have dramatically reduced the incidence of encapsulated bacterial diseases in toddlers under 2 years of age, but vaccine-induced antibody levels in this age group wane rapidly. We immunized adults and 12-month-old toddlers with heptavalent pneumococcal conjugate vaccine to determine differences …

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A New Combination Haemophilus influenzae Type B and Neisseria meningitidis Serogroup C-Tetanus Toxoid Conjugate Vaccine for Primary Immunization of Infants

David Pace, Matthew D. Snape, Sharon Westcar, Mainga Hamaluba et autres

We conducted a phase 3 randomized controlled trial looking at the immunogenicity and safety of a novel combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine, Hib-MenC-TT in a 2-, 3-, and 4-month primary infant immunization schedule. …

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