Xiaoyan Zhao

Neural Network-Enhanced Robust Navigation for Vertical Docking of an Autonomous Underwater Shuttle Under USBL Outages

Xiaoyan Zhao, Canjun Yang, Yanhu Chen

Vertical docking of the autonomous underwater shuttle (AUS) for deep-sea data relay relies heavily on ultra-short baseline (USBL) acoustic positioning, whose measurements can be intermittently unavailable and contaminated by outliers in complex underwater environments. This paper proposes a neural network-enhanced robust navigation …

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Clinical features and outcome of arrhythmogenic cardiomyopathy because of a desmoglein-2 founder variant: A multicenter study

Bingqi Fu, Zhongli Chen, Zixian Chen, Yubi Lin et autres

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Bioengineered Microrobot for Targeted and Autonomous Eradication of Helicobacter pylori

Shali Tan, Ruijue Dan, Junfeng Guo, Qinglin Wei et autres

Helicobacter pylori (H. pylori) infection remains a major challenge in gastric disease treatment, with conventional antibiotic therapies hindered by poor gastric retention, lack of specificity, and the growing threat of bacterial resistance. To address these limitations, we introduce a novel bioengineered robotic …

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Artemisinin Protects Diabetic Cardiomyopathy by Inhibiting Ferroptosis via Upregulating Nrf2/NQO1 and GPX4 Pathways

Dongjie Li, Chunpu Song, Ling Huang, Xiaoyan Zhao

ABSTRACT Diabetic cardiomyopathy (DCM), a major lethal complication of diabetes, involves ferroptosis as a key pathogenic mechanism. Meanwhile, studies on the cardioprotective effect of artemisinin (Art) are mostly superficial, its specific mechanisms and whether it is related to ferroptosis is unclear. This …

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Multicenter research: tumor microenvironment features combined with tumor cell characteristics predict lymph node metastasis in early gastric cancer

Xiaozhuo Gao, Xiaoyan Zhao, Huihui Xu, Ning Zhang et autres

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Fully coupled conductive–convective thermo-poroelasticity modeling of pore–fracture systems in geological reservoirs

Xinle Zhai, Xing Wei, Xilin Lü, Xiaoyan Zhao

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Comparing therapeutic effects of hematopoietic stem cell transplantation, tyrosine kinase inhibitors and chemotherapy in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: a systematic review and meta-analysis

Xiaohui Gao, Hui Zeng, Fei Sun, Xiaoyan Zhao et autres

Objective Both hematopoietic stem cell transplantation (HSCT) and chemotherapy combined with tyrosine kinase inhibitors (TKIs) have shown therapeutic efficacy in patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). This study aimed to compare the clinical outcomes of HSCT and TKI-combined chemotherapy …

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Development and validation of a nomogram for in-hospital mortality prediction in acute myocardialinfarction patients with cardiac arrest undergoing percutaneous coronary intervention supported by veno-arterial extracorporeal membrane oxygenation

Haina Li, Mingxuan Duan, Guoyu Duan, Yan Zhou et autres

BACKGROUND: The combination of percutaneous coronary intervention (PCI) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has become a widely used approach for resuscitating patients with acute myocardial infarction (AMI) complicated by cardiac arrest (CA). Nonetheless, limited research has focused on predicting in-hospital mortality …

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Array-Based Rapid Identification of Herbal Medicines via a Bifunctional Color-BiLink Strategy

Chao Guo, Huihai Li, Xiaoyan Zhao, Yong Li et autres

Ensuring the authenticity and quality of herbal medicines, particularly licorice, a pivotal component in nearly 60% of traditional Chinese medicine formulations, remains a significant global challenge. However, conventional approaches lack the capacity for direct, rapid, and high-throughput differentiation of licorice mixtures and …

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Mechanism of action of decitabine in treating acute lymphoblastic leukemia

Xiaohui Gao, Hui Zeng, Fei Sun, Xiaoyan Zhao et autres

Purpose This study aimed to evaluate the underlying mechanisms of decitabine (DAC) in inhibiting acute T-acute lymphoblastic leukemia (T-ALL) cell proliferation and promoting apoptosis. Methods Human T-ALL cells (CCRF-CEM) were treated with varying concentrations of DAC, and cell proliferation was assessed using …

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7th international symposium on phytochemicals in medicine and food

Xiaoyan Zhao

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Artemisinin Alleviates Alcohol-Induced Cardiotoxicity by Inhibiting Ferroptosis via the Nrf2/NQO1 Pathway In Vivo and In Vitro

Chunpu Song, Ling Huang, Dongjie Li, Xiaoyan Zhao

The present study was designed to explore the protective effects of artemisinin on alcohol-induced cardiac injuries and its mechanisms. In H9c2 cells, cell viability, reactive oxygen species (ROS), labile iron pool (LIP), and mitochondrial membrane potential (MMP) were measured. In the mouse …

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