Sang‐Jae Park

Prevalence and Potential Clinical Relevance of Germline Pathogenic Variants in Korean Biliary Tract Cancer

Jun-Ha Jang, Jong Eun Park, Jung Won Chun, Hyeji Kim et autres

Purpose: This study aimed to identify germline pathogenic/likely pathogenic variants in DNA damage repair genes associated with increased cancer risk in Korean patients with biliary tract cancer and characterize their population-specific patterns. Materials and Methods: In this retrospective multicenter cohort study, we …

us, kr (code pays fourni par la source)

Depletion-free Automated Enrichment of Serum Glycopeptides for High-Throughput Clinical Glycoproteomics

Jung Hoon Choi, Geul Bang, Jong Hyun Seol, Seong Woo Choi et autres

High-throughput and reproducible enrichment of N-glycopeptides remains a major bottleneck in large-scale and clinical glycoproteomics, despite substantial advances in mass spectrometry. Here, we present a depletion-free, high-throughput N-glycopeptide enrichment workflow (3kMAX) that combines 3 kDa molecular weight cut-off filtration with positive-pressure-driven mixed …

kr (code pays fourni par la source)

Risk of Intrahepatic and Extrahepatic Cancers in Hepatitis C Virus Infection: A Nationwide Cohort Study in Korea, 2005–2023

Yoon Park, Byung‐Woo Kim, Jin‐Kyoung Oh, Bo Hyun Kim et autres

BACKGROUND & AIMS: We evaluated the association between hepatitis C virus (HCV) infection and the risk of intrahepatic and extrahepatic cancers. Specifically, we compared "1st" versus "1st or 2nd" primary cancers to capture the true disease burden, which is often underestimated in …

us, kr (code pays fourni par la source)

The 2024 Korean Enhanced Recovery After Surgery guidelines for hepatobiliary and pancreatic surgery

Kwangpyo Hong, Hongbeom Kim, Hyung Sun Kim, Hae Won Lee et autres

Purpose: The Korean Enhanced Recovery After Surgery (ERAS) Committee within the Korean Society of Surgical Metabolism and Nutrition has developed comprehensive guidelines for hepatobiliary and pancreatic (HBP) surgery by adapting established international protocols. These guidelines provide evidence-based recommendations specifically tailored to the …

kr (code pays fourni par la source)

FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse

Gözde Inci, Madhuri Shende Warkad, Beom-Goo Kang, Sung-Ok Kim et autres

kr (code pays fourni par la source)

Diagnostic Biomarker Candidates Proposed Using Targeted Lipid Metabolomics Analysis of the Plasma of Patients with PDAC

Sung‐Sik Han, Sang Myung Woo, Jun Hwa Lee, Joon Hee Kang et autres

Background/Objectives: We recently discovered that tumors rely on blood fatty acids as an energy source for growth. Therefore, we investigated biomarkers in the lipid fractions of plasma from patients with pancreatic ductal adenocarcinoma (PDAC) for the screening diagnosis of PDAC. Methods: We …

kr, us (code pays fourni par la source)

Incidence, mortality, and survival of gallbladder, extrahepatic bile duct, and pancreatic cancers in Korea: A population-based study from 1999 to 2022

Mee Joo Kang, Eun Hye Park, E Hwa Yun, Hye-Jin Kim et autres

Backgrounds/Aims: Biliary tract and pancreatic cancers remain leading contributors to cancer-related mortality in Korea, even though their incidence rates are comparatively low. This study evaluates long-term national patterns in these malignancies utilizing population-based data. Methods: Information from the Korea Central Cancer Registry …

kr (code pays fourni par la source)

Optimal Value of Mutant KRAS Circulating Tumor DNA for Predicting Prognosis and Monitoring in Patients with Pancreatic Adenocarcinoma: A Prospective Multicenter Cohort Study

Jung Won Chun, Dong‐Eun Lee, Min Kyeong Kim, Jin‐Hyeok Hwang et autres

BACKGROUND: The generalizability and applicability of circulating tumor DNA (ctDNA) KRAS mutations in patients with pancreatic adenocarcinoma (PAC) remain elusive. We aimed to propose a cut-off value of mutant KRAS (mKRAS) concentration in ctDNA and validate its clinical utility. METHODS: This prospective, …

us, Éthiopie, kr, pr (code pays fourni par la source)

Abstract 2153: Preliminary analysis of immune cell profiling to neoadjuvant chemotherapy response in pancreatic cancer patients

Byeong-Gon Kim, Sung Jun Kim, Tae Young Kim, Sung-Sik HAN et autres

Abstract Background: Neoadjuvant chemotherapy (NAT) is used in the clinical setting to improve the chance of surgery for pancreatic cancer (PC) patients. Immune profiling shows great promise for improved prediction of response to chemotherapy, But the role of the immune system of …

kr (code pays fourni par la source)

Development of a pre- and re-habilitation protocol for gastrointestinal cancer surgery

Eun Young Kim, Jung Hoon Bae, J.S. Kim, Eun Joo Yang et autres

Purpose: Surgical resection is the primary curative treatment for gastrointestinal (GI) cancer; however, it is associated with high postoperative complication rates and impaired recovery. Frailty, malnutrition, and sarcopenia increase morbidity and mortality, underscoring the need for perioperative rehabilitation programs. Standardized rehabilitation protocols …

kr, us (code pays fourni par la source)

The 2024 Korean Enhanced Recovery After Surgery (ERAS) guidelines for colorectal cancer: a secondary publication

Kil‐yong Lee, Soo Young Lee, Miyoung Choi, Moon Jin Kim et autres

The Korean Enhanced Recovery After Surgery (ERAS) Committee within the Korean Society of Surgical Metabolism and Nutrition was established to develop ERAS guidelines tailored to the Korean context. This guideline focuses on creating the most current evidence-based practice guidelines for ERAS purposes, …

kr, us (code pays fourni par la source)

The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886

Ji-Young Jang, Myung-Ju Lee, Myung‐Shin Lee, Jinjong Myoung et autres

All cellular transcripts initially have a tri-phosphate (PPP) group at the 5'-end, recognized as a pathogen-associated molecular pattern (PAMP) by a cell's innate immune system. The removal of 5'-PPP occurs to varying extents, causing immune imbalance. However, how cells manage this situation …

kr, us (code pays fourni par la source)