T. Van den Bosch

Prospective external validation of ADNEX and RMI for estimating risk of malignancy in adnexal masses in general gynecological settings: Danish multicenter study

Ina Marie Dueholm Hjorth, Bodil Hammer Bech, Ashleigh Ledger, C. Möller et autres

OBJECTIVES: The primary aims of this study were to validate externally the diagnostic performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model for distinguishing between malignant and benign adnexal masses, when used by non-expert ultrasound examiners in general gynecological …

dk, be, ru (code pays fourni par la source)

Increased Mast Cell Numbers in Bone Marrow of Patients with Myeloproliferative Neoplasms and Pruritus

Maud Hermans, P E Westerweel, T. Van den Bosch, Willem A. Dik et autres

Pruritus might be a debilitating symptom in myeloproliferative neoplasms (MPN).Since mast cells (MC) play a pivotal role, we hypothesized that bone marrow (BM) MC contribute to the cause of pruritus.In this exploratory study, untreated MPN patients were included.BM aspirate/biopsy/blood and MPN-SAF questionnaires …

nl, Afrique du Sud (code pays fourni par la source)

Delta-like ligand 3 expression in isocitrate dehydrogenase-mutant and isocitrate dehydrogenase-wildtype glioma is largely retained at recurrence, supporting its potential as a therapeutic target

Rosa Luning, Sybren L. N. Maas, Pim J. French, Youri Hoogstrate et autres

Abstract Background Delta-like ligand 3 (DLL3), an inhibitory Notch ligand, is now explored as a therapeutic target in recurrent diffuse glioma. Since clinical trials may select patients with recurrent glioma based on DLL3 expression in the primary tumor, this study aims to …

nl, de, at (code pays fourni par la source)

Ultrasound as a noninvasive diagnostic tool to detect deep endometriosis using the International Deep Endometriosis Analysis terminology

Céline Bafort, G. Condous, Dominique Van Schoubroeck, Gábor Viktor Szabó et autres

be, au, hu, gb, it, es, il (code pays fourni par la source)

A Novel Semi‐Quantified Method for Grading Sonographic Severity of Adenomyosis and its Relation With Clinical Symptoms

Lisa M. Trommelen, Cilla Verbeek, T. Van den Bosch, Karin P. M. van Galen et autres

OBJECTIVE: To correlate the sonographic severity of adenomyosis, assessed with real-time ultrasound and a novel semi-quantified method (XI-VOCAL counting and categories) with adenomyosis-associated symptoms. METHODS: This observational study was conducted in a tertiary referral outpatient clinic. We consecutively included 115 participants with …

nl, be (code pays fourni par la source)

Letter to the Editor: Iatrogenic breaching of the junctional zone: the unintended path to placenta accreta spectrum?

Jolien Haesen, Kobe Dewilde, Hannes van der Merwe, T. Van den Bosch

Over the past four decades, hysteroscopy has become a widely used diagnostic and therapeutic tool in gynaecology.We therefore strongly support research including clinical follow-up data after hysteroscopic procedures.

be (code pays fourni par la source)

P18.23.A AUTOLOGOUS ORGANOTYPIC MULTICELLULAR SPHEROIDS (OMS) AS A PRECLINICAL PLATFORM FOR STUDYING PERSONALIZED GLIOBLASTOMA IMMUNOTHERAPY

Kevin Jimenez-Cowell, T. Van den Bosch, R de Geus, Andi Basuki et autres

Abstract BACKGROUND Immunotherapies for glioblastoma (GBM), including oncolytic viruses, have shown encouraging responses in a small subset of patients, but overall clinical efficacy remains limited. A major hurdle is GBM’s inter- and intra-tumoral heterogeneity, particularly within its immunosuppressive tumor microenvironment (TME), which …

nl (code pays fourni par la source)

P08.04.B DLL3 IS EXPRESSED IN GLIOMA AND IS LARGELY RETAINED AT RECURRENCE, MAKING IT A SUITABLE TARGET FOR IMMUNOTHERAPIES

Rosa Luning, S L Maas, Pim J. French, Richard D. Head et autres

Abstract BACKGROUND Gliomas invariably recur after first-line treatment, and there is a dire need for new therapeutic options at recurrence. Delta-like protein 3 (DLL3) is a ligand in the Notch signalling pathway. It is expressed in several cancers, such as small cell …

nl, at (code pays fourni par la source)

Prevalence of cesarean scar disorder in patients 3 years after a first cesarean section

Saskia J M Klein Meuleman, Carry Verberkt, Pere N. Barri, Ally Murji et autres

INTRODUCTION: A symptomatic uterine niche is a long-term complication after a cesarean section (CS). A group of international niche experts reached consensus on a standardized definition of a disorder caused by a symptomatic niche, named cesarean scar disorder (CSDi). However, the prevalence …

nl, es, ca, gb, gr, be, cn, pl, jp (code pays fourni par la source)

Addendum to consensus opinion from the International Deep Endometriosis Analysis ( IDEA ) group: sonographic evaluation of superficial endometriosis

S. Guerriero, George Stanley Condous, Martino Rolla, Marcelo Pedrassani et autres

Traditionally, laparoscopy was considered to be the gold standard for the examination of endometriotic lesions, because it allows their direct visualization. Several international and national guidelines have now shifted their focus to non-invasive imaging-based diagnosis of deep endometriosis in preference to surgery, …

it, au, br, ca, gb, at, es, be (code pays fourni par la source)

Euro-Chinese consensus on accessory cavitated uterine malformation*,†

Lan Zhu, Zichen Zhao, Attilio Di Spiezio Sardo, Maribel Acién et autres

Background: Accessory cavitated uterine malformations (ACUMs) are a rare obstructive uterine anomaly that remains poorly understood, posing challenges for clinical management. The aetiopathogenesis is hypothesised to involve the duplication and persistence of ductal Müllerian tissue usually near the round ligament attachment, potentially …

cn, it, es, gb, be, hk, gr (code pays fourni par la source)

Euro-Chinese consensus on accessory cavitated uterine malformation

Lan Zhu, Zichen Zhao, Attilio Di Spiezio Sardo, Maribel Acién et autres

Accessory cavitated uterine malformation (ACUM) is a rare obstructive uterine anomaly that remains poorly understood, posing challenges for clinical management. The aetiopathogenesis is hypothesised to involve the duplication and persistence of ductal Müllerian tissue usually near the round ligament attachment, potentially related …

cn, it, es, gb, be, hk, gr (code pays fourni par la source)