Sigrid Valen Hestetun

Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study

V.Ø. Dåstøl, Ida Henriette Caspersen, Kristine L. Haftorn, Sigrid Valen Hestetun et autres

OBJECTIVES: The intrauterine environment may influence childhood immune-mediated disease risk. We investigated whether maternal prepregnancy body mass index (BMI), gestational weight gain (GWG) or hypertensive disorders during pregnancy (HDP) were associated with juvenile idiopathic arthritis (JIA) in children and whether genetic susceptibility …

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Birth-Related Factors and Risk of Juvenile Idiopathic Arthritis: Findings from Two Prospective, Nationwide, Norwegian Cohorts

V.Ø. Dåstøl, Ida Henriette Caspersen, Kristine L. Haftorn, Sigrid Valen Hestetun et autres

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OP0211 BIRTH-RELATED FACTORS AND RISK OF JUVENILE IDIOPATHIC ARTHRITIS (JIA): FINDINGS FROM TWO PROSPECTIVE, NATIONWIDE, NORWEGIAN COHORTS

V.Ø. Dåstøl, Ida Henriette Caspersen, Kristine L. Haftorn, Sigrid Valen Hestetun et autres

Background: Most studies on juvenile idiopathic arthritis (JIA) etiology are case-control studies, susceptible to biases such as recall and selection bias. A meta-analysis of 66 environmental factors (including 11 cohort and 28 case-control studies), concluded that cesarean section (c-section) increases JIA risk, …

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POS1065 NONLINEARITY AND SEX DIFFERENCES IN THE PERFORMANCE OF A POLYGENIC RISK SCORE FOR JUVENILE IDIOPATHIC ARTHRITIS

Kristine L. Haftorn, Hamid Khoshfekr Rudsari, Piotr Jahołkowski, V.Ø. Dåstøl et autres

Background: Juvenile idiopathic arthritis (JIA) results from an interplay of genetic and environmental factors, but the underlying mechanisms remain largely unknown. Familial, twin, and genome-wide association studies (GWAS) have helped to approach and dissect the genetic contribution to JIA [1, 2]. However, …

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Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis

Kristine L. Haftorn, Hamid Khoshfekr Rudsari, Piotr Jahołkowski, V.Ø. Dåstøl et autres

Background: Juvenile idiopathic arthritis (JIA) is an immune-mediated pediatric disease believed to result from a complex interplay of genetic and environmental factors. Genome-wide association studies have enabled calculation of polygenic risk scores (PRS) for JIA. Understanding how the PRS associates with JIA …

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Sigrid Valen Hestetun, Kristine L. Haftorn, Ketil Størdal, Helga Sanner

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude

Sigrid Valen Hestetun, Hamid Khoshfekr Rudsari, Piotr Jahołkowski, Alexey Shadrin et autres

OBJECTIVE: We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in the three geographic regions of Norway and whether potential regional incidence differences are explained by environmental or genetic factors across regions. METHODS: We conducted a register-based cohort study including …

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Fetal and Early-Life Antibiotics and Risk of Pediatric Inflammatory Bowel Disease: A Population-Based Nationwide Register Study

Svend Andersen, Sigrid Valen Hestetun, Tomm Bernklev, Gøri Perminow et autres

Objective: To assess whether antibiotic exposure prenatally and before 2 years of age is associated with subsequent pediatric inflammatory bowel disease (PIBD), as earlier studies diverge substantially in risk estimations or do not include prenatal exposure. Methods: , code registrations consistent with …

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Antibiotic exposure in prenatal and early life and risk of juvenile idiopathic arthritis: a nationwide register-based cohort study

Sigrid Valen Hestetun, Svend Andersen, Helga Sanner, Ketil Størdal

OBJECTIVES: Early antibiotic exposure influences the gut microbiota which is believed to be involved in the pathogenesis of juvenile idiopathic arthritis (JIA). We aimed to investigate the association between systemic antibiotics in prenatal and early life and risk of JIA. METHODS: We …

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S124 Antibiotic Exposure Before 2 Years of Age is Associated With Increased Risk of Pediatric IBD in a Norwegian Nation-Wide Study

Svend Andersen, Sigrid Valen Hestetun, Tomm Bernklev, Gøri Perminow et autres

Background: The incidence of pediatric IBD (PIBD) rises. This development is likely related to environmental factors that cause disturbances in the gut microbiota. The infant’s microbiome is shaped among other factors by exposure to the maternal microbiome and reaches adult diversity around …

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Correction to: Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort

Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun et autres

An amendment to this paper has been published and can be accessed via the original article.

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THU0537 VALIDITY AND DIAGNOSTIC PERFORMANCE OF FLUORESCENCE OPTICAL IMAGING MEASURING SYNOVITIS IN HAND OSTEOARTHRITIS. RESULTS FROM THE NOR-HAND STUDY.

Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Tore K Kvien et autres

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