Ian Simms

O-44 - UNDERSTANDING SEXUALLY TRANSMITTED SHIGELLA CLUSTERS TO HELP CONTROL SPREAD

Ms Holly Fountain, Ian Simms, Hannah Charles, Katy Sinka

Abstract Background Since the emergence of sexually transmitted Shigella among gay, bisexual and other men who have sex with men (GBMSM) circa 2008, cases have been increasing, often within persistent genomic clusters. Objectives Describe sexually transmitted Shigella clusters to better understand transmission …

An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk

Samuel M. Lancaster, Samson J. Mataraso, Jonathan D. Reiss, Kévin Contrepois et autres

Metabolites present in the mother traverse the placenta to supply energy, essential nutrients, and communication signals to the fetus. To gain a deeper understanding of fetal metabolism and the impacts of maternal metabolic health and medications on the fetus, we have created …

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Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei , England

Hannah Charles, David R. Greig, Craig Swift, Israel Olonade et autres

gene variant entered the lineage on a novel resistance plasmid coinciding with the first outbreak case. Our analysis highlights the shifting antimicrobial resistance landscape of sexually transmitted Shigella bacteria. Parallel emergence of resistance determinants against third-generation cephalosporins in sexual transmission networks suggests …

Adapting the Flexible Farrington Algorithm for daily situational awareness and alert system to support public health decision-making during the SARS-CoV-2 epidemic in England

Ian Simms, André Charlett, Felipe J. Colón‐González, Paula Bianca Blomquist et autres

The Flexible Farrington Algorithm (FFA) is widely used to detect infectious disease outbreaks at national/regional levels on a weekly basis. The rapid spread of SARS-CoV-2 alongside the speed at which diagnostic and public health interventions were introduced made the FFA of limited …

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Using demographics of patients to inform treatment of shigellosis in England

Lewis C. E. Mason, DANIEL C. RICHARDSON, Hannah Charles, Ian Simms et autres

Shigellosis, caused by bacteria of the genus Shigella, is a diarrhoeal disease transmitted by the faecal–oral route.1 Rapid increases in the prevalence of extensively drug-resistant (XDR) Shigella isolates—also known as triple-resistant due to resistance to fluoroquinolones, third-generation cephalosporins, and azithromycin—during the final …

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Outbreak of sexually transmitted S. sonnei bla CTX-M-15 in England: an epidemiological and genomic investigation

Hannah Charles, David R. Greig, Craig Swift, Israel Olonade et autres

Abstract The diarrhoeal disease, shigellosis, can be sustained as a sexually transmissible enteric illness among gay, bisexual, and other men who have sex with men (GBMSM). Multiple extensively drug-resistant strains of Shigella have been detected through genomic surveillance, which have typically been …

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Deep Metabolic Phenotyping of Newborn Cord Blood Reveals Maternal-Fetal Interactions and Diet-Disease Associations

Samuel M. Lancaster, Samson M Matarso, Jonathan D. Reiss, Kévin Contrepois et autres

Objectives: Pregnant mothers use metabolites that cross the placenta to provide energy, structural components, essential nutrients, and signals to the developing fetus. However, fetal availability and absorption of many critical metabolites have not been investigated in healthy or diseased states; and associations …

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Trends in shigellosis notifications in England, January 2016 to March 2023

Hannah Charles, Katy Sinka, Ian Simms, Kate S. Baker et autres

Abstract We reviewed all diagnoses of Shigella species notified to the UK Health Security Agency from January 2016 to March 2023. An overall increase in notifications of shigellosis was seen between 2016 (n = 415/quarter) and 2023 (n = 1 029/quarter). However, …

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Influence of SARS-CoV-2 surveillance outputs produced by the UK health security agency (UKHSA) outbreak surveillance team on decision-making by local stakeholders

Katriina Willgert, Jo Hardstaff, Stephanie Shadwell, Alex Bhattacharya et autres

BACKGROUND: The UK Health Security Agency (UKHSA) COVID-19 Outbreak Surveillance Team (OST) was established in June 2020 to provide Local Authorities (LAs) in England with surveillance intelligence to aid their response to the SARS-CoV-2 epidemic. Reports were produced using standardised metrics in …

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Multi-omics microsampling for the profiling of lifestyle-associated changes in health

Xiaotao Shen, Ryan Kellogg, Daniel J. Panyard, Nasim Bararpour et autres

Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by geographical barriers, the cost and inconvenience of in-clinic …

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Accessible health care is critical to the effective control of sexually transmitted infections

Christopher Kincaid Fairley, Eric P. F. Chow, Ian Simms, Jane Simone Hocking et autres

Bacterial sexually transmitted infections (STIs) are rising relentlessly in virtually every country and among most risk groups. These infections have substantial individual and community consequences and costs. This review summarises the evidence for the effectiveness of different strategies to control STIs and …

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Metabolic profiling of placental tissue and maternal plasma to identify biomarkers of placenta accreta spectrum

Sarah E. Miller, Kévin Contrepois, Basil Michael, Giovanna Cruz et autres

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